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Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in Brazil.

Abstract：

:The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s, has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan Salvador, Brazil. Five years after the introduction of Hib conjugate vaccine, Hib meningitis incidence decreased from 2.39 to 0.06 cases per 100,000 population (98%) overall, and from 60.9 to 3.1 cases per 100,000 population (95%) in children <1 year of age. A transient serotype replacement phenomenon was observed associated with a small increase of meningitis due to two H. influenzae type a clonal groups. These findings indicate that Hib immunization campaign has led to the virtual elimination of Hib disease in this region.

journal_name

Vaccine

journal_title

Vaccine

authors

Ribeiro GS,Lima JB,Reis JN,Gouveia EL,Cordeiro SM,Lobo TS,Pinheiro RM,Ribeiro CT,Neves AB,Salgado K,Silva HR,Reis MG,Ko AI

doi

10.1016/j.vaccine.2007.03.024

subject

Has Abstract

pub_date

2007-05-30 00:00:00

pages

4420-8

issue

22

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(07)00332-5

journal_volume

25

pub_type

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