当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity.

Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity.

Abstract：

:Antibodies against the HIV-1 V1V2 loops were the only correlate of reduced infection risk in the RV144 vaccine trial, highlighting the V1V2 loops as promising targets for vaccine design. The V1V2 loops are structurally plastic, exhibiting either an α-helix-coil or β-strand conformation. V1V2-specific antibodies may thus recognize distinct conformations, and an antibody's conformational specificity can be an important determinant of breadth and function. Restricting V1V2 conformational plasticity in an immunogen may thus provide control over the conformational specificity and quality of a vaccine-elicited antibody response. Previously, we identified a V1V2 sequence variant (K155M) that results in enhanced recognition by cross-reactive antibodies recognizing the β-strand conformation. Here, we relate V1V2 antigenicity to immunogenicity by comparing the immunogenicity profiles of wildtype and K155M immunogens in two mouse models. In one model, immunization with gp70 V1V2 K155M but not wildtype elicited antibody responses that were cross-reactive to a panel of heterologous gp120 and gp140 antigens. In a second model, we compared the effect of K155M on immunogenicity in the context of gp70 V1V2, gD V1V2 and gp120, examining the effects of scaffold, epitope-focusing and immunization regimen. K155M variants, especially in the context of a gp120 immunogen, resulted in more robust, durable and cross-reactive antibody responses than wildtype immunogens. Restriction of the β-stranded V1V2 conformation in K155M immunogens may thus be associated with the induction of cross-reactive antibody responses thought to be required of a protective HIV-1 vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Lai JI,Eszterhas SK,Brooks SA,Guo C,Zolla-Pazner S,Seaman MS,Bailey-Kellogg C,Griswold KE,Ackerman ME

doi

10.1016/j.vaccine.2020.03.010

subject

Has Abstract

pub_date

2020-04-16 00:00:00

pages

3436-3446

issue

18

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(20)30354-6

journal_volume

38

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Comparative biological activities of whole cell pertussis vaccine and a new acellular preparation.

    abstract：:The biological activities of whole-cell pertussis vaccine and a new acellular preparation were compared. It was observed that both preparations were similarly effective in inducing protection in mice against intracerebral challenge with B. pertussis, however, the acellular preparation was approximately 200-fold more p...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/0264-410x(85)90005-2

    authors： García-Sánz JA,Ruiz-Puente J,Jiménez-Paredes J,González-Pacheco M,Villalva-Posada H

    更新日期：1985-03-01 00:00:00

  • Immunogenicity and safety of a booster vaccination against tick-borne encephalitis more than 3 years following the last immunisation.

    abstract：:This study investigated the immune response and safety in 430 adults, when boosted more than 3 years after primary or booster TBE immunisation as measured by neutralization test (NT) and ELISA. Tested by NT, the post-booster day 21 geometric mean titer (GMT) was 331 and 142 for the 18-49 and > or =50 years old, respec...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.vaccine.2004.07.002

    authors： Rendi-Wagner P,Kundi M,Zent O,Banzhoff A,Jaehnig P,Stemberger R,Dvorak G,Grumbeck E,Laaber B,Kollaritsch H

    更新日期：2004-12-09 00:00:00

  • pH-sensitive carbonate apatite nanoparticles as DNA vaccine carriers enhance humoral and cellular immunity.

    abstract：:To demonstrate the potential of pH-sensitive carbonate apatite (CO₃Ap) nanoparticles as DNA vaccine carriers to enhance vaccination efficacy, we examined the humoral and cellular immune responses of C57BL/6 mice immunized with the plasmid expression vector pCI-neo encoding the full-length soluble ovalbumin (OVA) (pCI-...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.09.032

    authors： He P,Takeshima SN,Tada S,Akaike T,Ito Y,Aida Y

    更新日期：2014-10-29 00:00:00

  • The benefits of redesigning Benin's vaccine supply chain.

    abstract：INTRODUCTION:New vaccine introductions have put strains on vaccine supply chains around the world. While increasing storage and transportation may be the most straightforward options, it is also important to consider what financial and operational benefits can be incurred. In 2012, suboptimal vaccine coverage and impen...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.04.090

    authors： Brown ST,Schreiber B,Cakouros BE,Wateska AR,Dicko HM,Connor DL,Jaillard P,Mvundura M,Norman BA,Levin C,Rajgopal J,Avella M,Lebrun C,Claypool E,Paul P,Lee BY

    更新日期：2014-07-07 00:00:00

  • Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects.

    abstract：:We previously observed that a detoxified Escherichia coli O111, Rc chemotype J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) vaccine protected animals from experimental lethal sepsis when immune antibodies were given passively as treatment at the onset of fever or when vaccine was giv...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0264-410x(03)00483-3

    authors： Cross AS,Opal SM,Palardy JE,Drabick JJ,Warren HS,Huber C,Cook P,Bhattacharjee AK

    更新日期：2003-11-07 00:00:00

  • Infectious bursal disease virus rescued efficiently with 3' authentic RNA sequence induces humoral immunity without bursal atrophy.

    abstract：:A reverse genetics infectious bursal disease virus (RG-IBDV) that contained authentic 3' RNA sequence was characterized both in vitro and in vivo. LP1-IBDV, a cell line-adapted IBDV strain variant E (VE) was used as the parent virus for constructing viral cDNA clones. Authentic 3' RNA sequence was generated by using c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.11.040

    authors： Mosley YY,Wu CC,Lin TL

    更新日期：2013-01-11 00:00:00

  • Frequency and erroneous usage of temporary medical exemptions and knowledge of immunization guidelines among some Miami-Dade County Florida providers.

    abstract：OBJECTIVE:We assessed knowledge and practices regarding immunization guidelines and the Florida Certificate of Immunization (DH-680) based on FL-DOH and CDC recommendations, to identify the cause of the increasing number of erroneously issued temporary medical exemptions (TME) among selected health care providers in Mi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.06.041

    authors： Cruze AR,Zhang G,Thomas L,Alonso J,Sandoval L

    更新日期：2014-07-31 00:00:00

  • In search of the active PZP epitope in white-tailed deer immunocontraception.

    abstract：:Native porcine zona pellucida (PZP) has been shown to be highly effective as an immunocontraceptive in white-tailed deer. However, the immunogenicity of PZP extracted from pig ovaries may vary from lot to lot and the extract has the potential of containing either viral or pathogenic material. Determination of the immu...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00195-0

    authors： Miller LA,Killian GJ

    更新日期：2002-06-21 00:00:00

  • Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release.

    abstract：:The incidence of Lyme disease has continued to rise despite attempts to control its spread. Vaccination of zoonotic reservoirs of human pathogens has been successfully used to decrease the incidence of rabies in raccoons and foxes. We have previously reported on the efficacy of a vaccinia virus vectored vaccine to red...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.07.059

    authors： Kern A,Zhou CW,Jia F,Xu Q,Hu LT

    更新日期：2016-08-31 00:00:00

  • Genome-wide association study of antibody response to smallpox vaccine.

    abstract：:We performed a genome-wide association study (GWAS) of antibody levels in a multi-ethnic group of 1071 healthy smallpox vaccine recipients. In Caucasians, the most prominent association was found with promoter SNP rs10489759 in the LOC647132 pseudogene on chromosome 1 (p=7.77×10(-8)). In African-Americans, we identifi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.04.055

    authors： Ovsyannikova IG,Kennedy RB,O'Byrne M,Jacobson RM,Pankratz VS,Poland GA

    更新日期：2012-06-13 00:00:00

  • A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or dengue virus infectivity.

    abstract：:West Nile virus (WNV) has caused multiple global outbreaks with increased frequency of neuroinvasive disease in recent years. Despite many years of research, there are no licensed therapeutics or vaccines available for human use. One of the major impediments of vaccine development against WNV is the potential enhancem...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.02.073

    authors： Lai H,Paul AM,Sun H,He J,Yang M,Bai F,Chen Q

    更新日期：2018-03-27 00:00:00

  • Population and risk group uptake of H1N1 influenza vaccine in mainland France 2009-2010: results of a national vaccination campaign.

    abstract：:A mass vaccination campaign against influenza A/H1N1 was launched in France in October 2009. Vaccination was offered free of charge to the entire population according to a pre-defined order of priority. Demographic data and data on vaccinations given were recorded in a dedicated database. We analysed vaccine uptake by...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.09.096

    authors： Bone A,Guthmann JP,Nicolau J,Lévy-Bruhl D

    更新日期：2010-11-29 00:00:00

  • Novel Adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag, Pol, Nef despite the presence of Ad5 immunity.

    abstract：:Recombinant Adenovirus serotype 5 (Ad5) vectors have been used as vaccine platforms in numerous animal and human clinical studies. The immune response induced by Ad5 vaccines can be mitigated due to pre-existing Ad5 immunity. We previously reported the use of a novel Ad5 platform to induce cellular immune responses (C...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.028

    authors： Gabitzsch ES,Xu Y,Yoshida LH,Balint J,Amalfitano A,Jones FR

    更新日期：2009-10-30 00:00:00

  • Rectal immunization of mice with hepatitis A vaccine induces stronger systemic and local immune responses than parenteral immunization.

    abstract：:Systemic (spleen cell (SPLC), serum antibodies) and intestinal mucosal (Peyer's patch cells (PPC), lamina propria lymphocytes (LPLs), coproantibodies) immune responses were compared in mice immunized with varying doses (144, 72, 36, 18 ELISA units [EU]) of HAVRIX, an alum-adsorbed killed hepatitis A virus (HAV) vaccin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00699-0

    authors： Mitchell LA,Galun E

    更新日期：2003-03-28 00:00:00

  • The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model.

    abstract：:Clostridium difficile infection (CDI) causes nosocomial antibiotic-associated diarrhea and colitis in the developed world. Two potent cytotoxins, toxin A (TcdA) and toxin B (TcdB) are the virulence factors of this disease and can be a good vaccine candidate against CDI. In the present study, we genetically engineered ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.02.006

    authors： Guo S,Yan W,McDonough SP,Lin N,Wu KJ,He H,Xiang H,Yang M,Moreira MA,Chang YF

    更新日期：2015-03-24 00:00:00

  • DNA vaccination with linear minimalistic (MIDGE) vectors confers protection against Leishmania major infection in mice.

    abstract：:Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the poten...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00450-4

    authors： López-Fuertes L,Pérez-Jiménez E,Vila-Coro AJ,Sack F,Moreno S,Konig SA,Junghans C,Wittig B,Timón M,Esteban M

    更新日期：2002-12-13 00:00:00

  • Immediate injection pain in infants aged 18 months during vaccination against measles, mumps and rubella with either Priorix or MMR-II.

    abstract：:The aim of this study was to investigate whether, the vaccine Priorix causes less immediate injection pain than MMR-II in vaccination of infants aged 18-24 months who were offered vaccine against measles, mumps and rubella. The infants were randomised into one of the two vaccine groups (Priorix/MMR-II in a double-blin...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2006.05.004

    authors： Knutsson N,Jansson UB,Alm B

    更新日期：2006-07-26 00:00:00

  • Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages.

    abstract：:Meningococcal disease is a serious medical condition that can prove fatal within hours in otherwise healthy individuals. Disease incidence is highest in infants, yet there is no broadly protective quadrivalent vaccine that covers this age group. A new investigational quadrivalent meningococcal glycoconjugate vaccine a...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2009.07.036

    authors： Bröker M,Dull PM,Rappuoli R,Costantino P

    更新日期：2009-09-18 00:00:00

  • Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.

    abstract：INTRODUCTION:Institutionalized mentally retarded subjects are well-known to be at-risk for HBV infection. We studied the persistence of vaccine-induced anti-HBs antibodies and the robustness of the HBsAg-specific immune memory in this population, 18-20 years after the first vaccine dose. MATERIALS AND METHODS:Non-immu...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.044

    authors： Braeckman T,Van Herck K,Jilg W,Bauer T,Van Damme P

    更新日期：2012-07-06 00:00:00

  • Defining hard-to-reach populations for vaccination.

    abstract：:Extending the benefits of vaccination to everyone who is eligible requires an understanding of which populations current vaccination efforts have struggled to reach. A clear definition of "hard-to-reach" populations - also known as high-risk or marginalized populations, or reaching the last mile - is essential for est...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2019.06.081

    authors： Ozawa S,Yemeke TT,Evans DR,Pallas SE,Wallace AS,Lee BY

    更新日期：2019-09-03 00:00:00

  • Treatment of cervical cancer in Italy: strategies and their impact on the women.

    abstract：:Treatment of cervical cancer greatly varies according to the stage of the disease. Laparoscopic surgical staging is emerging as a valid approach, compared to clinical and imaging staging, to better identify the treatment plan. Minimally invasive surgery plays the greatest role in the treatment of early cervical carcin...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.11.110

    authors： De Vincenzo R,Amadio G,Ricci C,Licameli A,Ferrandina G,Capelli G,Scambia G

    更新日期：2009-05-29 00:00:00

  • Analysis of adenovirus-induced immunity to infection with Listeria monocytogenes: Fading protection coincides with declining CD8 T cell numbers and phenotypic changes.

    abstract：:Defining correlates of T cell mediated protection is important in order to accelerate the development of efficient T cell based vaccines conferring long-term immunity. Extensive studies have provided important insight regarding the characteristics and functional properties of the effector and memory CD8 T cells induce...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.03.080

    authors： Jahn ML,Steffensen MA,Christensen JP,Thomsen AR

    更新日期：2018-05-11 00:00:00

  • An E2 sub-unit marker vaccine does not prevent horizontal or vertical transmission of classical swine fever virus.

    abstract：:An experimental infection with classical swine fever (CSF) virus in E2 sub-unit marker vaccine vaccinated gilts was conducted in order to evaluate the effect of vaccination on virus transmission and course of the disease. Therefore, clinical signs as well as horizontal and vertical virus transmission were monitored in...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00320-6

    authors： Dewulf J,Laevens H,Koenen F,Mintiens K,de Kruif A

    更新日期：2001-10-12 00:00:00

  • Human papillomavirus vaccine effectiveness by number of doses: Systematic review of data from national immunization programs.

    abstract：BACKGROUND:Human papillomavirus (HPV) vaccines were first licensed as a three-dose series; a two-dose series is now recommended in some age groups and there is interest in possible one-dose vaccination. METHODS:We conducted a systematic literature review of HPV vaccine effectiveness by number of doses, including asses...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2018.01.057

    authors： Markowitz LE,Drolet M,Perez N,Jit M,Brisson M

    更新日期：2018-08-06 00:00:00

  • Effect of hepatitis A vaccination schedules on immune response.

    abstract：:An inactivated hepatitis A vaccine was given to 104 seronegative volunteers aged between 19 and 60 years according to two schedules: 0, 1 and 2 months or 0, 1 and 6 months. The vaccine was well tolerated and 97 and 100% of vaccinees developed a serum antibody response following a single and two doses of vaccine respec...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0264-410x(92)90563-y

    authors： Tilzey AJ,Palmer SJ,Barrow S,Perry KR,Tyrell H,Safary A,Banatvala JE

    更新日期：1992-01-01 00:00:00

  • Similar long-term vaccine efficacy of two versus three doses of HBV vaccine in early life.

    abstract：:WHO currently recommends three vaccinations against hepatitis B to provide optimal protection against infection and carriage. However, immunological theory and mathematical modelling suggest that similar protection could be induced with two doses, and trials among adolescents and adults have shown comparable rates for...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.10.023

    authors： van der Sande MA,Mendy M,Waight P,Doherty C,McConkey SJ,Hall AJ,Whittle HC

    更新日期：2007-02-09 00:00:00

  • Long-term immunogenicity after single and booster dose of a live attenuated hepatitis A vaccine: results from 8-year follow-up.

    abstract：:Live, attenuated hepatitis A vaccines are used widely in China but there is uncertainty regarding the persistence of vaccine-induced anti-HAV antibodies after single dose and booster dose administrated at month 12. A large scale clinical trial to evaluate the live, attenuated hepatitis A vaccine was conducted in Hebei...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2006.08.004

    authors： Wang XY,Xu ZY,Ma JC,von Seidlein L,Zhang Y,Hao ZY,Han OP,Zhang YL,Tian MY,Ouyang PY,Zhang ZY,Han CQ,Xing ZC,Chen JC

    更新日期：2007-01-05 00:00:00

  • Peripheral CD4 T follicular cells induced by a conjugated pneumococcal vaccine correlate with enhanced opsonophagocytic antibody responses in younger individuals.

    abstract：BACKGROUND:PCV13 (conjugated polysaccharide) and PPSV23 (polysaccharide only) are two licensed vaccines targeting S. pneumoniae. The role of CD4 T-cell responses in pneumococcal vaccines among healthy participants and their impact on antibodies is not yet known. METHODS:Ten adults (5 old and 5 young) received PCV13 (p...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.12.023

    authors： Sterrett S,Peng BJ,Burton RL,LaFon DC,Westfall AO,Singh S,Pride M,Anderson AS,Ippolito GC,Schroeder HW Jr,Nahm MH,Krishna Prasad A,Goepfert P,Bansal A

    更新日期：2020-02-11 00:00:00

  • Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice.

    abstract：:Antibodies specific for Vibrio cholerae lipopolysaccaride (LPS) are common in humans recovering from cholera, and constitute a primary component of the vibriocidal response, a serum complement-mediated bacteriocidal response correlated with protection against cholera. In order to determine whether transcutaneous immun...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.040

    authors： Rollenhagen JE,Kalsy A,Saksena R,Sheikh A,Alam MM,Qadri F,Calderwood SB,Kovác P,Ryan ET

    更新日期：2009-08-06 00:00:00

  • Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies.

    abstract：:Mutations arising in neutralizing epitopes of hepatitis C virus may play a role in the ability of the virus to escape control by neutralizing antibodies and in the establishment of chronic infections. An amino-acid substitution, Q412H, within a major conserved neutralization epitope EP I (aa 412-426) in the E2 glycopr...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.04.024

    authors： Duan H,Struble E,Zhong L,Mihalik K,Major M,Zhang P,Feinstone S,Feigelstock D

    更新日期：2010-06-07 00:00:00