Abstract：
:Measles virus (MV) vaccine strains use CD46, signaling lymphocyte activation molecule, and nectin-4 in human cells as receptors. Meanwhile, many of them are propagated in primary chicken embryonic fibroblasts (CEFs). Our data revealed that CEFs express a nectin-4 homologous molecule (CEF nectin-4) containing well-conserved motifs in the FG and BC loops, but not in the C'C″ loop. MV infected CHO cells expressing CEF nectin-4 and induced syncytia in these cells, confirming that CEF nectin-4 functions as an MV receptor and that the C'C″ loop is not critical for this function. Nectin-4-blind mutations in MV H protein reduced the infectivity of MV in CEF nectin-4-expressing cells. Infection of CEFs with the MV vaccine AIK-C strain was partially blocked by an anti-nectin-4 antibody, indicating that CEF nectin-4 plays a role for propagation of MV vaccines in CEFs.
journal_name
Vaccinejournal_title
Vaccineauthors
Seki F,Someya K,Komase K,Takeda Mdoi
10.1016/j.vaccine.2015.10.109subject
Has Abstractpub_date
2016-01-02 00:00:00pages
7-12issue
1eissn
0264-410Xissn
1873-2518pii
S0264-410X(15)01565-0journal_volume
34pub_type
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