Abstract：
:The relevance of CD4+T-cells, viral load and age in the immunological response to influenza infection and vaccination in HIV-1 infected individuals has previously been pointed out. Our study aimed at assessing, in the setting of 2009 A(H1N1)pdm09 influenza vaccination, whether quantification of activation-induced deaminase (AID) expression in blood B-cells may provide additional indications for predicting antibody response to vaccination in HIV-1 infected patients with similar CD4+T-cell counts and age. Forty-seven healthy controls, 37 ART-treated and 17 treatment-naïve HIV-1 infected patients were enrolled in the study. Blood was collected prior to A(H1N1)pdm09 vaccination and at 1, 3 and 6 months after vaccination. Antibody titers to A(H1N1)pdm09 vaccine were measured by hemagglutination inhibition (HI) assay while the mRNA expression levels of AID were measured by quantitative real time PCR. Upon B-cell activation in vitro, AID increase correlated to antibody response to the A(H1N1)pdm09 vaccine at 1 month after vaccination in all individuals. In addition, the maximum expression levels of AID were significantly higher in those individuals who still carried protective levels of A(H1N1)pdm09 antibodies after 6 months from vaccination. No correlation was found between CD4+T-cell counts or age at vaccination or HIV-1 viral load and levels of A(H1N1)pdm09 antibodies. Assessing AID expression before vaccination may be an additional useful tool for defining a vaccination strategy in immune-compromised individuals at risk of immunization failure.
journal_name
Vaccinejournal_title
Vaccineauthors
Cagigi A,Pensieroso S,Ruffin N,Sammicheli S,Thorstensson R,Pan-Hammarström Q,Hejdeman B,Nilsson A,Chiodi Fdoi
10.1016/j.vaccine.2013.03.002subject
Has Abstractpub_date
2013-04-26 00:00:00pages
2231-7issue
18eissn
0264-410Xissn
1873-2518pii
S0264-410X(13)00261-2journal_volume
31pub_type
杂志文章相关文献
VACCINE文献大全abstract：BACKGROUND:A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RotaTeq™, RV5) against rotavirus gastroenteritis (RVGE). METHODS:4040 participants aged 6-12weeks were...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2017.08.081
更新日期：2017-10-13 00:00:00
abstract：:Human metapneumovirus (HMPV) is a major cause of morbidity and mortality from acute lower respiratory tract illness, with most individuals seropositive by age five. Despite the presence of neutralizing antibodies, secondary infections are common and can be severe in young, elderly, and immunocompromised persons. Precl...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.04.034
更新日期：2016-05-23 00:00:00
abstract：:HIV infection is characterized by chronic immune activation and the establishment of a pool of latently infected cells. Antiretroviral therapy (ART) can suppress viral load to undetectable levels in peripheral blood by standard measure, however immune activation/chronic inflammation and latent infection persist and af...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.04.015
更新日期：2020-06-02 00:00:00
abstract：:Through the specific and tight interaction between streptavidin and biotin, a novel platform was developed to allow for rapid (less than 2h), efficient and durable display of streptavidin-tagged bioactive GM-CSF on the surface of biotinylated B16.F10 tumor cells. This technology involved biotinylation of the cell memb...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.04.031
更新日期：2006-06-19 00:00:00
abstract：:Intranasal live attenuated influenza vaccine (LAIV) has potential for self-administration (SA) by adults and adolescents, which could save time and cost in mass vaccination settings. Participants in a study of LAIV in adults (n=4561) selected either SA or health care provider (HCP) administration and were followed for...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2012.12.028
更新日期：2013-01-30 00:00:00
abstract：:Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenici...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2006.04.068
更新日期：2006-07-07 00:00:00
abstract：:This study investigates the safety, immunogenicity and efficacy of different pox-vector vaccines expressing the haemagglutinin of a highly pathogenic (HP) H5N1 avian influenza virus (AIV) (A/chicken/Indonesia/7/03) in pigs. Pigs were vaccinated twice, with a 4-week interval, with a fowlpox (TROVAC), a canarypox (ALVAC...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.02.006
更新日期：2009-04-06 00:00:00
abstract：:A placebo-controlled, double-blind study on the efficacy of a hepatitis A vaccine (SmithKline Beecham Biologicals) was started in a region of Chile in September 1990, using hepatitis B vaccine as control. A total of 260 healthy children, 6-15 years of age, negative for antibody to hepatitis A virus (anti-HAV), antibod...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(92)90573-3
更新日期：1992-01-01 00:00:00
abstract：:Prevention of lifestyle-related diseases and promotion of physical and mental well-being in adolescents require an understanding of how life situations place adolescents at risk. The most important risk factors for hepatitis B virus (HBV) infection are sexual activity with more than one partner and injecting drug use....
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00458-2
更新日期：2000-02-18 00:00:00
abstract：BACKGROUND:Increased travel to exotic destinations around the world is escalating the risk of exposure to animal-associated injuries with a risk of acquiring rabies. METHODS:We have examined data reported to GeoSentinel Surveillance Network to highlight characteristics of animal-associated injuries in travellers. RES...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.12.034
更新日期：2007-03-30 00:00:00
abstract：:The hepatitis E virus (HEV) vaccine, Hecolin(®), was licensed in China for the prevention of HEV infection and HEV-related diseases with demonstrated safety and efficacy [1,2]. The vaccine is composed of a truncated HEV capsid protein, p239, as the sole antigen encoded by open reading frame 2 and produced using Escher...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.05.064
更新日期：2014-07-07 00:00:00
abstract：:We compared the effects of yeast-treated human dendritic cells (DCs) with CD40L-matured human DCs for the induction of effector cells and the number and functionality of CD4(+)CD25(+)CD127(-)FoxP3(+) regulatory T cells (Tregs). DCs were treated with yeast or CD40L and cocultured with isolated autologous CD4(+) T cells...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.04.101
更新日期：2011-07-12 00:00:00
abstract：:Surface proteins from several different life-cycle stages of the malaria parasite Plasmodium falciparum were expressed at high levels in the yeast Saccharomyces cerevisiae. Purified proteins, both individually and in cocktails, were used to immunize mice and goats in conjunction with either Freund's adjuvant or a mura...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(93)90287-8
更新日期：1993-01-01 00:00:00
abstract：:Thirty-two rhesus monkeys were used to evaluate the dose response of a recombinant HEV vaccine, and the efficacy of the vaccine based on the ORF2 protein of the Pakistani strain for pre- and post-exposure vaccination against intravenous challenge with homologous or heterologous virus was examined. Post-exposure vaccin...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(97)00145-x
更新日期：1997-12-01 00:00:00
abstract：:The low-molecular-mass secretory proteins of Mycobacterium tuberculosis have been shown to be major T-cell antigens during infection with the pathogenic bacterium. In this study, we determined murine T-cell epitopes on three low-molecular-mass proteins, CFP11 (Rv2433c), CFP17 (Rv1827), and TB18.5 (Rv0164) using DNA im...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.04.079
更新日期：2010-06-23 00:00:00
abstract：:The aim of this study was to determine the rubella seroprevalence in women of reproductive age. This cross-sectional study was conducted on women aged 15-49 years. Serologic studies were performed by using the ELISA method. The number of women enrolled in the study was 607, the mean age was 30.7+/-9.3 years and 13.2% ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.09.033
更新日期：2007-01-15 00:00:00
abstract：:Post-licensure vaccine safety studies often monitor for seizures using automated screening of ICD-9 codes. This study assessed the positive predictive value (PPV) of ICD-9 codes used to identify seizure visits in children aged 6 weeks to 23 months who were enrolled in seven managed care organizations during January 20...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.vaccine.2009.06.092
更新日期：2009-08-27 00:00:00
abstract：:Immunization with amyloid-beta (Abeta) peptide reduces amyloid load in animal studies and in humans; however clinical trials resulted in the development of a pro-inflammatory cellular response to Abeta. Apoptosis has been employed to stimulate humoral and Th2-biased cellular immune responses. Thus, we sought to invest...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.12.044
更新日期：2009-02-25 00:00:00
abstract：:Binding of antibodies to oligomeric envelope glycoprotein of R5-tropic primary isolates of human immunodeficiency virus type 1 (HIV-1) was studied by flow cytometry using sera from HIV-1 vaccine recipients and clade B and C HIV-1-infected patients, and monoclonal and polyclonal antibodies to neutralizing epitopes of H...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.07.013
更新日期：2004-01-02 00:00:00
abstract：:Bovine papillomaviruses (BPVs) are the causative agent of bovine teat papillomatosis, which can lead to severe economic losses in dairy cattle. Among the 14 identified BPV genotypes, BPV type 6 (BPV6) is the most frequently detected in teat papilloma lesions, and is therefore thought to play a major role in teat papil...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.08.079
更新日期：2017-10-13 00:00:00
abstract：:The recent resurgence of pertussis in England and Wales has been marked by infant deaths and rising cases in teens and adults. To understand which age cohorts are most responsible for these trends, we employed three separate statistical methods to analyze high-resolution pertussis reports from 1982 to 2012. The fine-g...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.01.046
更新日期：2018-02-21 00:00:00
abstract：:Serological results obtained in a single laboratory from twin-studies on maternal immunisation, in Vietnam and Belgium offer the opportunity to compare antibody kinetics in infants before and after infant vaccination in the presence of vaccine-induced maternal antibodies. Nonlinear mixed-effects models (NLMMs) making ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.09.003
更新日期：2020-10-21 00:00:00
abstract：:Promotional campaigns recommend immunisation against influenza in healthcare workers (HCWs) but the uptake in this group remains low. We conducted a survey study during the 2008-2009 influenza vaccination period amongst future HCWs to quantify uptake and identify barriers to immunisation. Overall uptake was 8.0% (95% ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.04.066
更新日期：2010-06-23 00:00:00
abstract：:At the Netherlands Vaccine Institute (NVI) a vaccine against Neisseria meningitidis serogroup B organisms based on different porA subtypes contained in outer membrane vesicles (OMVs) is in advanced stage of development and will be evaluated in clinical trial studies in the near future. In order to meet the expected de...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.06.008
更新日期：2007-08-21 00:00:00
abstract：:Envelope glycoprotein E2 is the most immunogenic protein of classical swine fever virus (CSFV). In a proposed model of the antigenic structure of E2, the N-terminal half of E2 forms two independent structural antigenic units, A and BC. E2 without transmembrane region (E2-TMR) is expressed and secreted into the medium ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00215-1
更新日期：1999-02-05 00:00:00
abstract：:We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes a systemic infection allowing the isolation of viable chlamydiae from several organs for several days post-infection (p.i.). In particular, spleen infection occurred up to Day 7 p.i. in 100% of anima...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.09.035
更新日期：2004-03-12 00:00:00
abstract：:Intramuscular immunization of mice with DNA cocktail vaccines, comprising potential protective antigens P36, P46, NrdF, and P97or P97R1 of Mycoplasma hyopneumoniae, induced strong Th1-polarized immune responses against each antigen, with only P46 eliciting a serum IgG response. Subcutaneous immunization with protein c...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.06.005
更新日期：2008-08-12 00:00:00
abstract：INTRODUCTION:Rotavirus infection mainly affects children under 5 years of age and causes 453,000 deaths annually throughout the world. Several countries in Latin America have introduced the rotavirus vaccine and the majority have epidemiological data to measure impact following vaccine introduction. OBJECTIVE:To asses...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2013.05.065
更新日期：2013-07-02 00:00:00
abstract：:Given the ethical aspects of vaccination policies and current threats to public trust in vaccination, it is important that governments follow clear criteria for including new vaccines in a national programme. The Health Council of the Netherlands developed such a framework of criteria in 2007, and has been using this ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.10.008
更新日期：2014-12-12 00:00:00
abstract：:Salmonella enterica serovar Gallinarum causes fowl typhoid in chickens and is of economic importance to the chicken industry. A serovar Gallinarum live vaccine strain 9R (SG 9R) has been used to control fowl typhoid in many areas where the disease is endemic. Because the attenuation mechanism of SG 9R was not defined,...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.08.048
更新日期：2012-10-05 00:00:00
