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Evaluation of immune response to recombinant potential protective antigens of Mycoplasma hyopneumoniae delivered as cocktail DNA and/or recombinant protein vaccines in mice.

Abstract：

:Intramuscular immunization of mice with DNA cocktail vaccines, comprising potential protective antigens P36, P46, NrdF, and P97or P97R1 of Mycoplasma hyopneumoniae, induced strong Th1-polarized immune responses against each antigen, with only P46 eliciting a serum IgG response. Subcutaneous immunization with protein cocktail vaccines, surprisingly, induced both Th1-polarized immune response as well as antibody response whereas mice immunized with DNA cocktail vaccines followed by boosting with protein cocktail vaccines generated strong Th1-polarized and humoral immune responses. P97 was not recognized by serum antibodies from commercial bacterin-immunized mice indicating potential lack of expression of this important antigen in inactivated whole-cell vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Chen AY,Fry SR,Daggard GE,Mukkur TK

doi

10.1016/j.vaccine.2008.06.005

subject

Has Abstract

pub_date

2008-08-12 00:00:00

pages

4372-8

issue

34

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)00719-6

journal_volume

26

pub_type

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