Abstract：
INTRODUCTION:Hepatitis B is a major preventable cause of morbidity and mortality from chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. We aimed to evaluate the performance and outcomes of the Korean Perinatal Hepatitis B Prevention Programme (PHBPP) and to investigate the impact of the current post-exposure immunoprophylaxis protocol. METHODS:A retrospective cohort study was performed based on electronic data registry of infants born to hepatitis B virus (HBV)-infected mothers between July 2002 and 2013. RESULTS:During the study period, 159,983 Korean infants were registered with the PHBPP, with an overall programme coverage of 92.8%. Despite receiving timely post-exposure immunoprophylaxis, 8.6% of infants born to mothers aged <25 years and hepatitis B e antigen (HBeAg)-positive, and 0.7% of infants born to mothers aged ≥25 years and HBeAg-negative were infected. An estimated 14,123 infants were directly protected from perinatal HBV transmission by the PHBPP during the 11.5-year period, at a cost of 1157 US dollars per case averted. The incidence of paediatric hepatocellular carcinoma declined dramatically during the period. CONCLUSIONS:A substantial number of infants have been prevented from hepatitis B since the PHBPP was launched in the Republic of Korea. Continued efforts to promote the programme, an integrated approach to maximising its coverage, a risk-stratified strategy, and innovations in logistics could further reduce perinatal HBV transmission.
journal_name
Vaccinejournal_title
Vaccineauthors
Yang TU,Jung CW,Kim D,Park HA,Jee Ydoi
10.1016/j.vaccine.2020.05.044subject
Has Abstractpub_date
2020-07-22 00:00:00pages
5532-5540issue
34eissn
0264-410Xissn
1873-2518pii
S0264-410X(20)30689-7journal_volume
38pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Dengue is a major infectious disease that affects people living in tropical and subtropical regions around the world. The causative agents are dengue virus serotype 1, 2, 3, and 4 (DENV1, 2, 3, and 4). Developing a vaccine for dengue is a high priority for public health, but traditional methods have faced numerous obs...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.03.091
更新日期：2014-06-24 00:00:00
abstract：:Mucosal but not parenteral vaccination with whole Leishmania amazonensis promastigotes antigens (LaAg) is known to increase host resistance to infection by an as yet unknown immune mechanism. Since early immune responses are critical for infection establishment, in the present study the differential responses elicited...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.03.020
更新日期：2018-04-25 00:00:00
abstract：BACKGROUND:Human papillomavirus (HPV) vaccination offers potential for primary prevention of HPV-related pre-cancers and cancers as demonstrated in clinical trials. Mathematical models have estimated the potential real-life impact of vaccination on the burden of cervical cancer (CC). However, these are restricted to ev...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.11.049
更新日期：2014-02-03 00:00:00
abstract：:HIV vaccines of the first generation are, in contrast to most currently licensed vaccines, unlikely to provide sterilizing immunity against infection with HIV. However, they are expected to exert a beneficial effect on the maintenance of CD4 T-cell counts by reducing viral load. There is a recognized need for clarifyi...
journal_title：Vaccine
pub_type：
doi：10.1016/j.vaccine.2008.12.029
更新日期：2009-03-23 00:00:00
abstract：:Seneca Valley virus (SVV) infection in pigs is associated with porcine idiopathic vesicular disease (PIVD). Outbreaks of SVV infection in pig herds have been reported in several Asia and Americas countries. Recently, a series of outbreaks of SVV infection occurred in China, Canada, Thailand and the United States. Howe...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.12.055
更新日期：2018-02-01 00:00:00
abstract：:We have demonstrated that the fibrinogen-albumin-IgG receptor of group C streptococci (FAI) targets B-cells in vivo. We exploited the targeting properties of FAI to improve the immune responses stimulated by soluble antigens administered by the mucosal route. Enhanced systemic and mucosal immune responses were observe...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.08.045
更新日期：2005-02-03 00:00:00
abstract：:Ten prospective clinical trials conducted in elderly and high-risk adults have failed to show that pneumococcal vaccine prevents pneumococcal bacteraemia and all pneumonia. Several of these trials focused on unrepresentative populations and most had serious methodological problems. Few adequately considered sample siz...
journal_title：Vaccine
pub_type： 杂志文章,meta分析
doi：10.1016/j.vaccine.2003.09.027
更新日期：2004-02-25 00:00:00
abstract：OBJECTIVES:To assess immunogenicity and safety of the 23-valent polysaccharide pneumococcal vaccine (PPV23) in juvenile idiopathic arthritis (JIA) patients under conventional DMARDs with or without anti-TNF therapy. The influences of demographic data, disease activity and treatment on immune response and the potential ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.12.030
更新日期：2015-01-29 00:00:00
abstract：:The neuraminidase (NA) protein of influenza A viruses (IAV) has important functional roles in the viral replication cycle. Antibodies specific to NA can reduce viral replication and limit disease severity, but are not routinely measured. We analyzed NA inhibiting (NI) antibody titers in serum and respiratory specimens...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.06.001
更新日期：2016-07-19 00:00:00
abstract：:Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.02.074
更新日期：2018-04-12 00:00:00
abstract：:Routine administration of the quadrivalent human papillomavirus (HPV) vaccine has been recommended for 11-12-year-old males since 2011, but coverage remains low. In a U.S. national sample of parents of 11-17-year-old males (n=779), 78.6% of parents reported their sons had not received the HPV vaccine. The most common ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.05.035
更新日期：2014-06-30 00:00:00
abstract：OBJECTIVE:This study sought to evaluate the acceptability of inactivated influenza vaccine delivered by microneedle patch (MNP) in comparison to inactivated influenza vaccine (IIV) delivered by hypodermic needle. DESIGN, SETTING, AND PARTICIPANTS:From the general population of Atlanta, Georgia, we screened 112 and enr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.07.064
更新日期：2020-10-21 00:00:00
abstract：BACKGROUND:Influenza vaccines are now widely used to reduce the burden of annual epidemics of influenza virus infections. Influenza vaccine effectiveness (VE) is monitored annually to determine VE against each season's circulating influenza strains in different groups such as children, adults and the elderly. Few prosp...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.11.016
更新日期：2016-01-02 00:00:00
abstract：:We examined the immunogenicity and protective efficacy of a combined DNA vaccine that included six genes encoding immunodominant antigens from Mycobacterium tuberculosis and Brucella abortus. The IL-12 adjuvant system was used for immunization in combination with the combined DNA vaccine (DNA-IL-12(+)). Mice immunized...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.06.061
更新日期：2007-09-17 00:00:00
abstract：:We performed a genome-wide association study (GWAS) of antibody levels in a multi-ethnic group of 1071 healthy smallpox vaccine recipients. In Caucasians, the most prominent association was found with promoter SNP rs10489759 in the LOC647132 pseudogene on chromosome 1 (p=7.77×10(-8)). In African-Americans, we identifi...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.04.055
更新日期：2012-06-13 00:00:00
abstract：:The paramyxoviruses respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) are the two most common agents of severe lower respiratory tract disease in infants and children throughout the world. RSV causes yearly epidemics of bronchiolitis and pneumonia in infants and young children, while PIV3 is a co...
journal_title：Vaccine
pub_type：
doi：10.1016/0264-410x(95)98266-d
更新日期：1995-03-01 00:00:00
abstract：:Plasmodium falciparum Pfs25 antigen, expressed on the surface of zygotes and ookinetes, is one of the leading targets for the development of a malaria transmission-blocking vaccine (TBV). Our laboratory has been evaluating DNA plasmid based Pfs25 vaccine in mice and non-human primates. Previously, we established that ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.05.006
更新日期：2013-06-28 00:00:00
abstract：:Cysteine peptidases (CPs) have been implicated in various processes central to the pathogenicity of Leishmania parasites, and are thought to be key factors in the host-parasite interaction. In order to fully evaluate the potential of the CPs as vaccine candidates, studies in natural host species are required. In the s...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.12.039
更新日期：2006-03-24 00:00:00
abstract：:Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prev...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(02)00389-4
更新日期：2002-12-19 00:00:00
abstract：BACKGROUND:Invasive meningococcal disease has a high burden in young children, particularly during infancy. We investigated the immunogenicity and safety of a quadrivalent meningococcal conjugated vaccine (MenACWY-TT) co-administered with routine vaccines in healthy infants. METHODS:In this phase IIIb study (NCT013408...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2018.05.046
更新日期：2018-06-27 00:00:00
abstract：:The incidence of Lyme disease has continued to rise despite attempts to control its spread. Vaccination of zoonotic reservoirs of human pathogens has been successfully used to decrease the incidence of rabies in raccoons and foxes. We have previously reported on the efficacy of a vaccinia virus vectored vaccine to red...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.07.059
更新日期：2016-08-31 00:00:00
abstract：:In order to evaluate in humans the safety and immunogenicity of a Pseudomonas aeruginosa vaccine composed of outer membrane proteins (OMPs), CFC-101, we carried out a phase I/IIa clinical trial in healthy male volunteers. Groups of six volunteers were immunized either subcutaneously (s.c.) or intramuscularly (i.m.) wi...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/s0264-410x(98)00159-5
更新日期：1999-01-01 00:00:00
abstract：:The whole cell vaccine (WCV) of Bordetella pertussis is protective in the intracerebral (i.c.) mouse protection assay. We found a correlation between the i.c. mouse protection assay potency and the presence of the virulence-associated outer membrane proteins (OMPs) in outer membrane complexes (OMC). The virulence-asso...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)00040-t
更新日期：1995-01-01 00:00:00
abstract：:Duck Tembusu virus (TMUV) is an emerging pathogenic flavivirus that causes severe egg-drop and fatal encephalitis in domestic ducks and geese. Although a live-attenuated virus vaccine is effective for disease control, the stability of the attenuation has not been clearly evaluated due to a poor understanding of the at...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.10.080
更新日期：2020-01-22 00:00:00
abstract：:Cell culture-based manufacturing of influenza vaccines is ideally based on easily scalable platforms using suspension cells that grow in chemically defined media. Consequently, different adherent cell lines selected for high virus yields were adapted to grow in suspension culture. This includes the MDCK suspension cel...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.09.051
更新日期：2013-11-19 00:00:00
abstract：OBJECTIVE:We related seroprevalence and outbreaks data in order to identify factors that could explain the occurrence of outbreaks despite high vaccination coverage in Medellín Colombia. METHODS:Samples from a population seroprevalence data obtained in 2009 in a random survey were analyzed. IgG levels were determined ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.08.088
更新日期：2015-10-13 00:00:00
abstract：:Vesicular stomatitis virus (VSV) has been extensively utilized as a viral vector system for the induction of protective immune responses against a variety of pathogens. We constructed recombinant VSVs specifying either the Indiana or Chandipura virus G glycoprotein and expressing the West Nile virus (WNV) envelope (E)...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.11.087
更新日期：2009-02-05 00:00:00
abstract：:Visceral leishmaniasis, caused by the intracellular parasite Leishmania donovani is a significant public health problem in many regions of the world. Anti-leishmanial immune defences are primarily dependent on the ability of the host to mount an interleukin-12 (IL-12) driven Th1 type of responses. Thus, IL-12 plays a ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.11.058
更新日期：2006-03-20 00:00:00
abstract：INTRODUCTION:It is important to quickly identify parent beliefs, intentions, and behaviors toward childhood vaccination, especially parents of children 19 to 35 months. This paper describes parental immunization beliefs, intentions, and behaviors; assesses the relationships between beliefs and intentions regarding chil...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.01.032
更新日期：2020-02-28 00:00:00
abstract：:Since its registration in 2002, Gudair® vaccine has become the key tool for managing paratuberculosis in sheep in Australia. This study was conducted to evaluate its effectiveness in reducing paratuberculosis prevalence in 12 flocks over more than one decade. Flocks with variable initial prevalence (5, 4 and 3 with lo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.08.064
更新日期：2016-09-30 00:00:00
