Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release.

abstract：:The recombinant vaccinia viruses expressing the surface protein of Neospora caninum tachyzoite, NcSAG1 or NcSRS2, were constructed. The vaccination with these recombinant viruses could protect effectively the parasite invasion in a mouse model system. The vaccine efficacy of NcSRS2 was higher than that of NcSAG1. The ...

journal_title：Vaccine

authors： Nishikawa Y,Inoue N,Xuan X,Nagasawa H,Igarashi I,Fujisaki K,Otsuka H,Mikami T

更新日期：2001-01-08 00:00:00

abstract：:The objective of this study was to investigate the prevalence of hepatitis B markers in a representative sample of 2142 subjects in Catalonia, Spain, and to compare it with previous studies. Multiple logistical regression analysis was carried out to determine variables associated with the markers studied. The prevalen...

journal_title：Vaccine

authors： Domínguez A,Bruguera M,Vidal J,Plans P,Salleras L

更新日期：2000-05-08 00:00:00

abstract：:Anti-tumor vaccination is being evaluated as a prophylactic and therapeutic strategy against cancer growth, dissemination (spreading) or recurrence. Although a large number of studies investigate in detail the identity of antigens to be used for efficacious immune intervention, there have been few studies investigatin...

journal_title：Vaccine

authors： Parvanova I,Rettig L,Knuth A,Pascolo S

更新日期：2011-05-17 00:00:00

abstract：:Although studies have described factors associated with pertussis hospitalization in children, data on adult hospitalization are sparse. We examined the association between patient characteristics and hospitalization among older adults with pertussis. We conducted a nested case-control study of participants in the 45 ...

journal_title：Vaccine

authors： Karki S,McIntyre P,Newall AT,MacIntyre CR,Banks E,Liu B

更新日期：2015-10-13 00:00:00

abstract：:We have developed the Mycobacterium tuberculosis (Mtb) fusion protein (ID83), which contains the three Mtb proteins Rv1813, Rv3620 and Rv2608. We evaluated the immunogenicity and protective efficacy of ID83 in combination with several emulsion-formulated toll-like receptor agonists. The ID83 subunit vaccines containin...

journal_title：Vaccine

authors： Baldwin SL,Bertholet S,Kahn M,Zharkikh I,Ireton GC,Vedvick TS,Reed SG,Coler RN

更新日期：2009-05-18 00:00:00

abstract：:Immunization of boars against GnRH inhibits synthesis of testicular anabolic steroids and the sex odour androstenone. Time between second vaccination and return of Leydig cell function is unknown. Six catheterized boars received the second dose (Improvac) at 26 weeks of age (day 0). Titre, LH, testicular steroids, and...

journal_title：Vaccine

authors： Claus R,Rottner S,Rueckert C

更新日期：2008-08-18 00:00:00

abstract：:Synthetic oligonucleotides (ODNs) containing immunostimulatory CpG motifs (CpG) are a new class of adjuvants suitable for the development of recombinant vaccines. Here we describe that endogenous interferon (IFN) was critical for the adjuvant activity of CpG ODN as genetically deficient mice developed significantly lo...

journal_title：Vaccine

authors： Rosa DS,Bastos KR,Bargieri DY,Tzelepis F,Nomizo A,Russo M,Soares IS,Rodrigues MM

更新日期：2007-08-10 00:00:00

abstract：:Particle-mediated (gene gun) DNA transfer to the epidermis was evaluated for its ability to elicit humoral and cytotoxic T lymphocyte responses using decreasing quantities of plasmid DNA-based antigen expression vectors. Using plasmids encoding human growth hormone, human alpha-1-antitrypsin, and influenza virus nucle...

journal_title：Vaccine

authors： Pertmer TM,Eisenbraun MD,McCabe D,Prayaga SK,Fuller DH,Haynes JR

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:In outbreak settings, mass vaccination strategies could maximize health protection of military personnel. Self-administration of live attenuated influenza vaccine (LAIV) may be a means to vaccinate large numbers of people and achieve deployment readiness while sparing the use of human resources. METHODS:A p...

journal_title：Vaccine

authors： Burgess TH,Murray CK,Bavaro MF,Landrum ML,O'Bryan TA,Rosas JG,Cammarata SM,Martin NJ,Ewing D,Raviprakash K,Mor D,Zell ER,Wilkins KJ,Millar EV

更新日期：2015-07-31 00:00:00

abstract：:The use of pneumococcal polysaccharide vaccine (PPV) is low in some countries, maybe because of doubts regarding its efficacy. This meta-analysis aims at combining evidence from randomized trials of PPV assessing its efficacy in preventing Streptococcus pneumoniae related diseases in immunocompetent adults. In the fou...

journal_title：Vaccine

authors： Cornu C,Yzèbe D,Léophonte P,Gaillat J,Boissel JP,Cucherat M

更新日期：2001-09-14 00:00:00

abstract：:Envelope glycoprotein E2 is the most immunogenic protein of classical swine fever virus (CSFV). In a proposed model of the antigenic structure of E2, the N-terminal half of E2 forms two independent structural antigenic units, A and BC. E2 without transmembrane region (E2-TMR) is expressed and secreted into the medium ...

journal_title：Vaccine

authors： van Rijn PA,van Gennip HG,Moormann RJ

更新日期：1999-02-05 00:00:00

abstract：:National Organized Cervical Cancer Screening (NOCCS) programs are lacking in most of the "Extended Middle East and North Africa" (EMENA) countries. Consequently, most cervical cancers are diagnosed late and are associated with high mortality. In fact, in most of these countries, national mortality data are unknown due...

journal_title：Vaccine

authors： Sancho-Garnier H,Khazraji YC,Cherif MH,Mahnane A,Hsairi M,El Shalakamy A,Osgul N,Tuncer M,Jumaan AO,Seoud M

更新日期：2013-12-30 00:00:00

abstract：:Recombinant poxviruses are well suited for the development of new vaccine vectors. Our previous data supported the idea that Myxomavirus (MYXV) is efficient at priming antibody responses in sheep. To provide definitive evidence on the potential of MYXV for vaccination against infectious diseases in ruminants, we inves...

journal_title：Vaccine

authors： Top S,Foucras G,Deplanche M,Rives G,Calvalido J,Comtet L,Bertagnoli S,Meyer G

更新日期：2012-02-21 00:00:00

abstract：:Triton X-100 (TX-100) is the most common surfactant used to split viruses during the production of influenza split-virus vaccines. It is a mild surfactant not known to denature the viral proteins; this property makes TX-100 useful for maintaining antigen conformational structure, and, as an added benefit, for partiall...

journal_title：Vaccine

authors： Sahin Z,Neeleman R,Haines J,Kayser V

更新日期：2019-02-14 00:00:00

abstract：:Pneumococcal and Salmonella typhi infections are two major diseases for children in developing countries. For typhoid fever, licensed Vi polysaccharide vaccines are ineffective in children <2-year old. While investigational Vi conjugate vaccines have been shown effective in clinical trials, they are currently only ava...

journal_title：Vaccine

authors： Lu YJ,Zhang F,Sayeed S,Thompson CM,Szu S,Anderson PW,Malley R

更新日期：2012-05-14 00:00:00

abstract：:The incidence of cervical cancer in Latin America and the Caribbean (LAC) is among the highest in the world. Because there are major demographic shifts happening in LAC countries (population growth, urbanization and ageing) cervical cancer incidence and mortality will likely continue to be a significant public health ...

journal_title：Vaccine

authors： Almonte M,Albero G,Molano M,Carcamo C,García PJ,Pérez G

更新日期：2008-08-19 00:00:00

abstract：:Following routine childhood vaccination against Haemophilus influenzae type b (Hib) disease in Brazil in 1999, passive laboratory surveillance reported increasing numbers of non-b serotypes and nontypeable H. influenzae (NTHi) from meningitis cases. To characterize this increase, we analyzed data on 3910 H. influenzae...

journal_title：Vaccine

authors： Zanella RC,Bokermann S,Andrade AL,Flannery B,Brandileone MC

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:This randomised, open label, phase I, immunotherapeutic study investigated the effects of interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), recombinant human growth hormone (rhGH), and therapeutic immunisation (a Clade B DNA vaccine) on combination antiretroviral therapy (cART)-t...

journal_title：Vaccine

authors： Herasimtschuk A,Downey J,Nelson M,Moyle G,Mandalia S,Sikut R,Adojaan M,Stanescu I,Gotch F,Imami N

更新日期：2014-12-05 00:00:00

abstract：:Effective antigen delivery is one of the most important issues in vaccine development. It has been suggested that adjuvant action results from a depot effect by prolonging the duration of the interaction between antigen and cells, and thus is related to the antigen-releasing properties of emulsion adjuvants. The objec...

journal_title：Vaccine

authors： Yang YW,Wei AC,Shen SS

更新日期：2005-04-08 00:00:00

abstract：:Because of demonstrable cross-reactivity of cellular antigens contained in B subunit-killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines with antigens of various non-cholera species of the family Vibrionaceae (NCV), the protection conferred by the vaccines against diarrhoea associated with ...

journal_title：Vaccine

authors： Clemens JD,Harris JR,Kay BA,Chakraborty J,Sack DA,Ansaruzzaman M,Rahman R,Stanton BF,Khan MU,Khan MR

更新日期：1989-04-01 00:00:00

abstract：:Immunization with a combination of several virulence-associated proteins is one of the strategies of developing effective protein-based vaccines to enhance the protection against Streptococcus pneumoniae. In this study, we evaluated the protection effects against pneumococcal infection caused by S. pneumoniae TIGR4 in...

journal_title：Vaccine

authors： Cao J,Chen D,Xu W,Chen T,Xu S,Luo J,Zhao Q,Liu B,Wang D,Zhang X,Shan Y,Yin Y

更新日期：2007-06-28 00:00:00

abstract：:Feline panleukopenia virus (FPV) is an important infectious pathogen of all members of the family Felidae. Here, we describe construction of a replication-competent recombinant canine adenovirus type 2 (CAV-2) expressing the VP2 protein of FPV (CAV-2-VP2) by transfection of MDCK cells with recombinant CAV-2 genome car...

journal_title：Vaccine

authors： Yang S,Xia X,Qiao J,Liu Q,Chang S,Xie Z,Ju H,Zou X,Gao Y

更新日期：2008-03-10 00:00:00

abstract：:The safety, reactogenicity and immunogenicity of three candidate Lyme vaccines based on recombinant outer surface protein (OspA) presented in either lipidated or unlipidated forms, were assessed in 300 seronegative volunteers. Subjects received three doses of one of the three formulations at monthly intervals and were...

journal_title：Vaccine

authors： Van Hoecke C,Comberbach M,De Grave D,Desmons P,Fu D,Hauser P,Lebacq E,Lobet Y,Voet P

更新日期：1996-12-01 00:00:00

abstract：:A new rabies vaccine was developed from Vero cells adhered to microcarriers, cultivated in a bioreactor in serum-free medium and infected with the PV/VERO-Paris rabies virus strain. The viral suspensions were concentrated by tangential filtration, purified by chromatography and inactivated with beta-propiolactone. In ...

journal_title：Vaccine

authors： Frazatti-Gallina NM,Mourão-Fuches RM,Paoli RL,Silva ML,Miyaki C,Valentini EJ,Raw I,Higashi HG

更新日期：2004-12-09 00:00:00

abstract：:Trehalose-6,6'-dimycolate (TDM) and its monosaccharide-type analogues were synthesized, and their lethal and adjuvant activities were examined in mice. All the monosaccharide-type analogues with a glucose or N-acetylglucosamine moiety were devoid of lethal toxicity to mice; in particular, D-GlcNAcM(1-deoxy) and D-GlcN...

journal_title：Vaccine

authors： Sakurai T,Saiki I,Ishida H,Takeda K,Azuma I

更新日期：1989-06-01 00:00:00

abstract：:The assignment of infectious potency to test articles of adenovirus has been conducted mainly using classical end-point dilution methods, which rely on virus induced cytopathology to reveal the presence of infectious virus. These assays suffer the disadvantages of labor intensity, duration, throughput restriction and ...

journal_title：Vaccine

authors： Wang F,Puddy AC,Mathis BC,Montalvo AG,Louis AA,McMackin JL,Xu J,Zhang Y,Tan CY,Schofield TL,Wolf JJ,Lewis JA

更新日期：2005-08-22 00:00:00

abstract：:In 2004, we conducted a study in Piemonte (Italy), in order to describe incidence, treatment, hospitalizations and costs of herpes zoster (HZ), in population over 14 years of age. Twenty-four regional general practitioners, with 26,394 patients >14 years in charge (0.71% of the regional population), reported prospecti...

journal_title：Vaccine

authors： Di Legami V,Gianino MM,Ciofi degli Atti M,Massari M,Migliardi A,Tomba GS,Zotti C,Zoster Study Group.

更新日期：2007-10-23 00:00:00

abstract：OBJECTIVES:The objectives of this study were to estimate the national prevalence of hepatitis B infection in Tunisia using data from a nationwide survey, to compare results with those obtained in 1996 survey and to evaluate the impact of vaccination twenty years after its introduction. METHODS:A National household-bas...

journal_title：Vaccine

authors： Ben Hadj M,Bouguerra H,Saffar F,Chelly S,Hechaichi A,Talmoudi K,Bahrini A,Chouki T,Hazgui O,Hannachi N,Letaief H,Bellali H,Bahri O,Ben-Alaya-Bouafif N

更新日期：2018-09-18 00:00:00

abstract：INTRODUCTION:Despite the enormous benefits of childhood and maternal immunisation to individual and population health, the uptake of maternal vaccines during pregnancy remains suboptimal. Midwives are a trusted information source for parents and play an important role in the provision of immunisation information. Under...

journal_title：Vaccine

authors： Frawley JE,McKenzie K,Sinclair L,Cummins A,Wardle J,Hall H

更新日期：2020-01-10 00:00:00

abstract：:In many industrialized countries, hepatitis A incidence rates have declined steadily in the past decades. Since future cohorts of non-vaccinated elderly will lack protection against disease and the burden of hepatitis A is higher with increasing age, this could be an argument in favour of taking preventive measures su...

journal_title：Vaccine

authors： Suijkerbuijk AW,Lugnér AK,van Pelt W,Wallinga J,Verhoef LP,de Melker HE,de Wit GA

更新日期：2012-07-27 00:00:00