Abstract：
:The use of pneumococcal polysaccharide vaccine (PPV) is low in some countries, maybe because of doubts regarding its efficacy. This meta-analysis aims at combining evidence from randomized trials of PPV assessing its efficacy in preventing Streptococcus pneumoniae related diseases in immunocompetent adults. In the fourteen trials totalling 48,837 patients retrieved, PPV prevents definite pneumococcal pneumonia by 71%, presumptive pneumococcal pneumonia by 40%, and mortality due to pneumonia by 32%, but not all-cause pneumonia or death. No preventive effect was seen in the subgroup of patients aged 55 years or more, possibly due to a lack of statistical power.
journal_name
Vaccinejournal_title
Vaccineauthors
Cornu C,Yzèbe D,Léophonte P,Gaillat J,Boissel JP,Cucherat Mdoi
10.1016/s0264-410x(01)00217-1subject
Has Abstractpub_date
2001-09-14 00:00:00pages
4780-90issue
32eissn
0264-410Xissn
1873-2518pii
S0264410X01002171journal_volume
19pub_type
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