Abstract:
:Feline panleukopenia virus (FPV) is an important infectious pathogen of all members of the family Felidae. Here, we describe construction of a replication-competent recombinant canine adenovirus type 2 (CAV-2) expressing the VP2 protein of FPV (CAV-2-VP2) by transfection of MDCK cells with recombinant CAV-2 genome carrying a VP2 expression cassette. Ten 3-month-old cats were vaccinated with the recombinant virus with two boosters at 15-day intervals. All cats developed neutralizing antibodies of titers 1:16-1:32 by day 15 post-primary vaccination, increasing to 1:64-1:128 by day 45. Examination for clinical signs and viral presence, and total white blood cell counts in peripheral blood following FPV challenge, showed that all were completely protected. This recombinant virus appears to provide an effective alternative to attenuated and inactivated vaccines in immunizing cats against feline panleukopenia.
journal_name
Vaccinejournal_title
Vaccineauthors
Yang S,Xia X,Qiao J,Liu Q,Chang S,Xie Z,Ju H,Zou X,Gao Ydoi
10.1016/j.vaccine.2007.11.073subject
Has Abstractpub_date
2008-03-10 00:00:00pages
1482-7issue
11eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)01425-9journal_volume
26pub_type
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