Abstract：
:The whole cell vaccine (WCV) of Bordetella pertussis is protective in the intracerebral (i.c.) mouse protection assay. We found a correlation between the i.c. mouse protection assay potency and the presence of the virulence-associated outer membrane proteins (OMPs) in outer membrane complexes (OMC). The virulence-associated 92, 32 and 30 kDa OMPs were purified and the N-terminal amino acid sequences were determined. The N-terminal amino acid sequences of the 30 and 32 kDa OMPs show homology with the C-terminal fragment of the P.93 precursor of the 69 kDa OMP (pertactin). The purified 32 kDa OMP was protective in the i.c. test when presented as mixed protein-detergent micelles. The 92 kDa OMP became a protective antigen when nonprotective levels of pertussis toxin were added. We found a correlation between the i.c. mouse protection value and the 92 kDal38 kDa (porin) ratio in OMC preparations.
journal_name
Vaccinejournal_title
Vaccineauthors
Hamstra HJ,Kuipers B,Schijf-Evers D,Loggen HG,Poolman JTdoi
10.1016/0264-410x(94)00040-tsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
747-52issue
8eissn
0264-410Xissn
1873-2518pii
0264410X9400040Tjournal_volume
13pub_type
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