当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Inactivated meningococci and pertussis bacteria are immunogenic and act as mucosal adjuvants for a nasal inactivated influenza virus vaccine.

Inactivated meningococci and pertussis bacteria are immunogenic and act as mucosal adjuvants for a nasal inactivated influenza virus vaccine.

Abstract：

:Whole killed meningococci (Nm) and pertussis bacteria (Bp) were tested for mucosal immunogenicity and as mucosal adjuvants for an inactivated influenza virus vaccine given intranasally to unanaesthetized mice. Virus was given alone, or simply mixed with one of the bacterial preparations, in four doses at weekly intervals. The virus alone induced low but significant increases of influenza-specific IgG antibodies in serum measured by ELISA, whereas IgA responses in serum and saliva were insignificant compared to non-immunized controls. With Bp or Nm admixed, serum IgG and IgA and salivary IgA responses to the influenza virus were substantially augmented (P<0.005). However, this adjuvant effect of the bacterial preparations was not significant for responses in the intestine as measured by antibodies in faeces. Antibody responses to Bp itself, but not to Nm, were inhibited by the admixture of the virus vaccine. Moreover, the pertussis preparation induced salivary antibodies which cross-reacted with Nm. Whole-cell bacteria with inherent strong mucosal immunogenicity may also possess mucosal adjuvanticity for admixed particulate antigens which are weakly immunogenic by the nasal route.

journal_name

Vaccine

journal_title

Vaccine

authors

Berstad AK,Andersen SR,Dalseg R,Dromtorp S,Holst J,Namork E,Wedege E,Haneberg B

doi

10.1016/s0264-410x(99)00442-9

subject

Has Abstract

pub_date

2000-03-17 00:00:00

pages

1910-9

issue

18

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(99)00442-9

journal_volume

18

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Safety and immunogenicity of fully liquid and lyophilized formulations of an investigational trivalent group B streptococcus vaccine in healthy non-pregnant women: Results from a randomized comparative phase II trial.

    abstract：BACKGROUND:We evaluated the safety and immunogenicity of liquid and lyophilized formulations of an investigational trivalent group B streptococcus (GBS) vaccine in non-pregnant women and assessed the formulations' equivalence in terms of serotype-specific immune response. METHODS:This phase II, randomized, comparative...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.02.085

    authors： Beran J,Leroux-Roels G,Van Damme P,de Hoon J,Vandermeulen C,Al-Ibrahim M,Johnson C,Peterson J,Baker S,Seidl C,Dreisbach A,Karsten A,Corsaro B,Henry O,Lattanzi M,Bebia Z

    更新日期：2020-04-03 00:00:00

  • Review of vaccine hesitancy: Rationale, remit and methods.

    abstract：:Despite a wide array of safe and effective vaccines in use globally, with major impacts on health worldwide, the WHO Strategic Advisory Group of Experts (SAGE) on Immunization has been repeatedly confronted with reports of hesitancy towards accepting specific vaccines or vaccination programmes. This paper summarizes t...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2015.04.035

    authors： Schuster M,Eskola J,Duclos P,SAGE Working Group on Vaccine Hesitancy.

    更新日期：2015-08-14 00:00:00

  • Influenza vaccination policies for health workers in low-income and middle-income countries: A cross-sectional survey, January-March 2020.

    abstract：INTRODUCTION:The World Health Organization (WHO) recommends vaccination of health workers against influenza, but uptake in low-resource settings remains low. To complement routine global data collection efforts we conducted a detailed survey on influenza vaccination policies for health workers in low-income and middle-...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.10.001

    authors： Maltezou HC,Theodoridou K,Tseroni M,Raftopoulos V,Bolster A,Kraigsley A,Bresee J,Lambach P

    更新日期：2020-11-03 00:00:00

  • Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs.

    abstract：:In this study, the potential of N-Trimethyl chitosan (TMC, degree of quaternization 50%) and dextran microparticles for pulmonary delivery of diphtheria toxoid (DT) was investigated. The antigen-containing microparticles were prepared by drying of an aqueous solution of polymer and DT through a supercritical fluid (SC...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.05.064

    authors： Amidi M,Pellikaan HC,Hirschberg H,de Boer AH,Crommelin DJ,Hennink WE,Kersten G,Jiskoot W

    更新日期：2007-09-17 00:00:00

  • Visualizing knowledge and attitude factors related to influenza vaccination of physicians.

    abstract：PURPOSE:To characterize groups of primary healthcare physicians according to sociodemographic data, years of professional experience and knowledge of and attitudes to influenza, and to evaluate differences between groups with respect to influenza vaccination in the 2011-2012 season. METHODS:We carried out an anonymous...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.12.012

    authors： Antón-Ladislao A,García-Gutiérrez S,Soldevila N,González-Candelas F,Godoy P,Castilla J,Mayoral JM,Astray J,Martín V,Tamames S,Toledo D,Aguirre U,Domínguez A,CIBERESP Working Group for the Survey on Influenza Vaccination in Prim

    更新日期：2015-02-11 00:00:00

  • Antibody levels against tetanus and diphtheria after polychemotherapy for childhood sarcoma: a report from the Late Effects Surveillance System.

    abstract：BACKGROUND:It is known that antineoplastic treatment may induce secondary immunodeficiency, but studies after childhood sarcoma are rare. Since 1998, the Late Effects Surveillance System (LESS) of the German Society for Paediatric Oncology and Haematology (GPOH) prospectively registers late effects in soft tissue-, ost...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.vaccine.2010.12.084

    authors： Paulides M,Stöhr W,Laws HJ,Graf N,Lakomek M,Berthold F,Schmitt K,Niggli F,Jürgens H,Bielack S,Koscielniak E,Klingebiel T,Langer T

    更新日期：2011-02-11 00:00:00

  • Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in Brazil.

    abstract：:The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s, has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan Salvador, Brazil. Five years after the intro...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.03.024

    authors： Ribeiro GS,Lima JB,Reis JN,Gouveia EL,Cordeiro SM,Lobo TS,Pinheiro RM,Ribeiro CT,Neves AB,Salgado K,Silva HR,Reis MG,Ko AI

    更新日期：2007-05-30 00:00:00

  • A global pandemic influenza vaccine action plan.

    abstract：:In case of an influenza pandemic, the world will be in a situation where potential vaccine supply will fall short by several billion doses from global needs. The World Health Organization (WHO) convened in Geneva on May 2-3, 2006 a consultation of all stakeholders in influenza vaccines and immunization to identify pra...

    journal_title：Vaccine

    pub_type：

    doi：10.1016/j.vaccine.2006.07.021

    authors： Kieny MP,Costa A,Hombach J,Carrasco P,Pervikov Y,Salisbury D,Greco M,Gust I,LaForce M,Franco-Paredes C,Santos JI,D'Hondt E,Rimmelzwaan G,Karron R,Fukuda K

    更新日期：2006-09-29 00:00:00

  • Intervention effects from a social marketing campaign to promote HPV vaccination in preteen boys.

    abstract：OBJECTIVES:Adoption of human papillomavirus (HPV) vaccination in the US has been slow. In 2011, HPV vaccination of boys was recommended by CDC for routine use at ages 11-12. We conducted and evaluated a social marketing intervention with parents and providers to stimulate HPV vaccination among preteen boys. METHODS:We...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.05.044

    authors： Cates JR,Diehl SJ,Crandell JL,Coyne-Beasley T

    更新日期：2014-07-16 00:00:00

  • Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection.

    abstract：BACKGROUND:This randomised, open label, phase I, immunotherapeutic study investigated the effects of interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), recombinant human growth hormone (rhGH), and therapeutic immunisation (a Clade B DNA vaccine) on combination antiretroviral therapy (cART)-t...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2014.09.072

    authors： Herasimtschuk A,Downey J,Nelson M,Moyle G,Mandalia S,Sikut R,Adojaan M,Stanescu I,Gotch F,Imami N

    更新日期：2014-12-05 00:00:00

  • An inactivated yellow fever 17DD vaccine cultivated in Vero cell cultures.

    abstract：:Yellow fever is an acute infectious disease caused by prototype virus of the genus Flavivirus. It is endemic in Africa and South America where it represents a serious public health problem causing epidemics of hemorrhagic fever with mortality rates ranging from 20% to 50%. There is no available antiviral therapy and v...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.03.077

    authors： Pereira RC,Silva AN,Souza MC,Silva MV,Neves PP,Silva AA,Matos DD,Herrera MA,Yamamura AM,Freire MS,Gaspar LP,Caride E

    更新日期：2015-08-20 00:00:00

  • Soluble recombinant human metapneumovirus G protein is immunogenic but not protective.

    abstract：:Human metapneumovirus (HMPV) expresses the major surface glycoproteins F and G. We evaluated the protective efficacy of immunization with G. We generated a recombinant form of G ectodomain (GDeltaTM) that was secreted from mammalian cells and purified by affinity chromatography. We tested the immunogenicity of GDeltaT...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.04.007

    authors： Ryder AB,Tollefson SJ,Podsiad AB,Johnson JE,Williams JV

    更新日期：2010-06-07 00:00:00

  • Peripheral CD4 T follicular cells induced by a conjugated pneumococcal vaccine correlate with enhanced opsonophagocytic antibody responses in younger individuals.

    abstract：BACKGROUND:PCV13 (conjugated polysaccharide) and PPSV23 (polysaccharide only) are two licensed vaccines targeting S. pneumoniae. The role of CD4 T-cell responses in pneumococcal vaccines among healthy participants and their impact on antibodies is not yet known. METHODS:Ten adults (5 old and 5 young) received PCV13 (p...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.12.023

    authors： Sterrett S,Peng BJ,Burton RL,LaFon DC,Westfall AO,Singh S,Pride M,Anderson AS,Ippolito GC,Schroeder HW Jr,Nahm MH,Krishna Prasad A,Goepfert P,Bansal A

    更新日期：2020-02-11 00:00:00

  • Evaluation of a Salmonella Enteritidis vaccine and related ELISA for respective induction and assessment of acquired immunity to the vaccine and/or Echinacea purpurea in Awassi Ewes.

    abstract：:The aim of this study was to evaluate an experimental Salmonella Enteritidis (SE) bacterin and an indirect ELISA system to assess quantitatively the acquired immunity in Awassi ewes to the vaccine and/or Echinacea purpurea (EP) dried roots. Four treatments of the ewes were included in the experimental design, with 6 e...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.03.035

    authors： Barbour EK,Assi CAA,Shaib H,Hamadeh S,Murtada M,Mahmoud G,Yaghmoor S,Iyer A,Harakeh S,Kumosani T

    更新日期：2015-05-05 00:00:00

  • Avipox-based simian immunodeficiency virus (SIV) vaccines elicit a high frequency of SIV-specific CD4+ and CD8+ T-cell responses in vaccinia-experienced SIVmac251-infected macaques.

    abstract：:The ability of ALVAC- or fowlpox-based simian immunodeficiency virus (SIV) vaccines to boost SIV-specific CD4+ and CD8+ T-cell responses was tested in 10 vaccinia-experienced macaques infected with SIVmac251. The CD8+ T-cell response to the dominant Gag(181-189) CM9 was quantitated in seven Mamu-A*01-positive macaques...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.08.028

    authors： Nacsa J,Radaelli A,Edghill-Smith Y,Venzon D,Tsai WP,Morghen Cde G,Panicali D,Tartaglia J,Franchini G

    更新日期：2004-01-26 00:00:00

  • Liposomes enhance the immunogenicity of reconstituted influenza virus A/PR/8 envelopes and the formation of protective antibody by influenza virus A/Sichuan/87 (H3N2) surface antigen.

    abstract：:Reconstituted influenza virus (A/PR/8 strain) envelopes (RIVE) and influenza virus (A/Sichuan/87 (H3N2) strain) surface antigens were entrapped in dehydration-rehydration vesicles (DRV liposomes) composed of egg phosphatidylcholine (PC) or distearoyl phosphatidylcholine (DSPC DRV) and equimolar (32 mumol) cholesterol....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90509-i

    authors： Gregoriadis G,Tan L,Ben-Ahmeida ET,Jennings R

    更新日期：1992-01-01 00:00:00

  • Mucosal immunization with a replication-deficient adenovirus vector expressing murine cytomegalovirus glycoprotein B induces mucosal and systemic immunity.

    abstract：:The murine cytomegalovirus (MCMV) glycoprotein B (gB) gene was expressed in an adenovirus replication-deficient vector. This virus, designated Ad-gB, was used to immunize BALB/c and B6 mice by the intranasal (i.n.) route to induce an immune response. Following primary immunization, antibody was detected in serum of 10...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00037-9

    authors： Shanley JD,Wu CA

    更新日期：2003-06-02 00:00:00

  • Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system.

    abstract：:An enzymatically cleaved glycoprotein fragment (amino acids 28-328: 40 kDa) from influenza virus haemagglutinin (TOPS) was used to assess an intravaginal antigen delivery system, comprising lysophosphatidylcholine (LPC) and degradable starch microspheres (DSM). Three groups of three sheep received intravaginal immuniz...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(93)90313-m

    authors： O'Hagan DT,Rafferty D,Wharton S,Illum L

    更新日期：1993-01-01 00:00:00

  • Status of vaccine research and development for norovirus.

    abstract：:The global health community is beginning to gain an understanding of the global burden of norovirus-associated disease, which appears to have significant burden in both developed- and developing-country populations. Of particular importance is the growing recognition of norovirus as a leading cause of gastroenteritis ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2016.03.077

    authors： Riddle MS,Walker RI

    更新日期：2016-06-03 00:00:00

  • SOCS1 downregulation in dendritic cells promotes memory T-cell responses.

    abstract：:SOCS1-1 is crucial for control of immune cell cytokine expression, including those cytokines known to enable memory T-cell formation and homeostasis. In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8(+) T memory cells and ant...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.11.020

    authors： Aldrich M,Sanders D,Lapteva N,Huang XF,Chen SY

    更新日期：2008-02-20 00:00:00

  • Murine response to DNA encoding herpes simplex virus type-1 glycoprotein D targeted to the liver.

    abstract：:Plasmid DNA encoding herpes simplex virus type-1 glycoprotein D (gD-1) was complexed with asialoorosomucoid conjugated to poly-L-lysine. Following its intravenous injection into BALB/c mice, this complex was targeted to the liver. Liver cells expressing gD-1 were detected immunohistochemically through day 6 post-immun...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00438-7

    authors： Rogers JV,Hull BE,Fink PS,Chiou HC,Bigley NJ

    更新日期：2000-02-14 00:00:00

  • Implementation of a Q fever vaccination program for high-risk patients in the Netherlands.

    abstract：BACKGROUND:Between 2007 and 2011 the Netherlands was faced with an unprecedented Q fever outbreak with more than 4000 people affected. Dairy goats were considered the main source of infection. In addition to taking veterinary measures, the Dutch government offered an unlicensed vaccine against the causative bacterium C...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.03.062

    authors： Isken LD,Kraaij-Dirkzwager M,Vermeer-de Bondt PE,Rümke HC,Wijkmans C,Opstelten W,Timen A

    更新日期：2013-05-28 00:00:00

  • Effective mucosal immunization against respiratory syncytial virus using purified F protein and a genetically detoxified cholera holotoxin, CT-E29H.

    abstract：:We exploited the powerful adjuvant properties of cholera holotoxin (CT) to create a mucosally administered subunit vaccine against respiratory syncytial virus (RSV). A genetically detoxified mutant CT with an E to H substitution at amino acid 29 of the CT-A1 subunit (CT-E29H) was compared to wild type CT for toxicity ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00058-x

    authors： Tebbey PW,Scheuer CA,Peek JA,Zhu D,LaPierre NA,Green BA,Phillips ED,Ibraghimov AR,Eldridge JH,Hancock GE

    更新日期：2000-06-01 00:00:00

  • Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies.

    abstract：:Sip is a surface-exposed protein of GBS, which causes severe neonatal disease. Because Sip elicits a protective immune response in mice, we assessed whether pregnant women and newborns have Sip antibodies. Sera were collected from 644 pregnant women and 176 of their healthy newborns, and 10 newborns with GBS disease a...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.06.020

    authors： Manning SD,Wood S,Kasha K,Martin D,Rioux S,Brodeur B,Davies HD

    更新日期：2006-11-17 00:00:00

  • The Health Belief Model in predicting healthcare workers' intention for influenza vaccine uptake in Jordan.

    abstract：BACKGROUND:Theories of health behavior change are being inadequately adopted to understand the reasons behind low influenza vaccination rates among healthcare workers (HCWs). The Theory of Planned Behavior (TPB) is being used to predict intention-behavior relationship while the Health Belief Model (HBM) is being employ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.09.002

    authors： Alhalaseh L,Fayoumi H,Khalil B

    更新日期：2020-10-27 00:00:00

  • Post-marketing safety surveillance for inactivated and live-attenuated Japanese encephalitis vaccines in China, 2008-2013.

    abstract：INTRODUCTION:Two types of Japanese encephalitis (JE) vaccines, inactivated JE vaccine (JE-I) and live-attenuated JE vaccine (JE-L), are available and used in China. In particular, one JE-L, produced by a domestic manufacturer in China, was prequalified by WHO in 2013. We assessed the safety of JE vaccines in China duri...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.05.021

    authors： Wu W,Liu D,Li K,Nuorti JP,Nohynek HM,Xu D,Ye J,Zheng J,Wang H

    更新日期：2017-06-22 00:00:00

  • A recombinant vaccinia-rabies virus in the immunocompromised host: oral innocuity, progressive parenteral infection, and therapeutics.

    abstract：:With the emergence of raccoons (Procyon lotor) as the primary rabies reservoir in the United States of America, a recombinant vaccinia-rabies glycoprotein (V-RG) virus vaccine was developed that protected raccoons by the oral route from rabies infection. Despite extensive laboratory evaluation, vaccine safety concerns...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00163-6

    authors： Hanlon CA,Niezgoda M,Shankar V,Niu HS,Koprowski H,Rupprecht CE

    更新日期：1997-02-01 00:00:00

  • WHO strategy for the global elimination of new cases of hepatitis B.

    abstract：:Hepatitis B infection and its sequelae remain major public health problems internationally despite the existence of sensitive tests to screen blood and blood products for hepatitis B surface antigen (HBsAg) and immunogenic vaccines. Since the human hepatitis B virus has no known animal reservoir, a systematic vaccinat...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(90)90233-c

    authors： Ghendon Y

    更新日期：1990-03-01 00:00:00

  • White Paper on studying the safety of the childhood immunization schedule in the Vaccine Safety Datalink.

    abstract：:While the large majority of parents in the U.S. vaccinate their children according to the recommended immunization schedule, some parents have refused or delayed vaccinating, often citing safety concerns. In response to public concern, the U.S. Institute of Medicine (IOM) evaluated existing research regarding the safe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.10.082

    authors： Glanz JM,Newcomer SR,Jackson ML,Omer SB,Bednarczyk RA,Shoup JA,DeStefano F,Daley MF

    更新日期：2016-02-15 00:00:00

  • The outer membrane protein X from Escherichia coli exhibits immune properties.

    abstract：:Outer membrane proteins (OMP) are expressed in Gram-negative bacterial cell wall. OmpA from Klebsiella pneumoniae (KpOmpA) has been shown to bind and to activate selectively antigen presenting cells (APCs), eliciting protective CTL responses. In this study, we investigated whether OmpX, another member of the OMP famil...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00316-5

    authors： Maisnier-Patin K,Malissard M,Jeannin P,Haeuw JF,Corbière JC,Hoeffel G,Gauchat JF,Nguyen T,Saez JM,Delneste Y

    更新日期：2003-09-08 00:00:00