Abstract:
:Human metapneumovirus (HMPV) expresses the major surface glycoproteins F and G. We evaluated the protective efficacy of immunization with G. We generated a recombinant form of G ectodomain (GDeltaTM) that was secreted from mammalian cells and purified by affinity chromatography. We tested the immunogenicity of GDeltaTM in cotton rats. Animals were immunized with PBS, GDeltaTM alone or adjuvanted, or were infected once with HMPV, and challenged with live HMPV at 28 days. Animals vaccinated with adjuvanted and non-adjuvanted GDeltaTM developed high levels of serum antibodies to both recombinant and native G protein; however, vaccinated animals did not develop neutralizing antibodies and were not protected against virus challenge. Unlike the analogous non-fusion glycoproteins of other human paramyxoviruses, HMPV G does not appear to be a protective antigen. This represents an unusual feature of HMPV.
journal_name
Vaccinejournal_title
Vaccineauthors
Ryder AB,Tollefson SJ,Podsiad AB,Johnson JE,Williams JVdoi
10.1016/j.vaccine.2010.04.007subject
Has Abstractpub_date
2010-06-07 00:00:00pages
4145-52issue
25eissn
0264-410Xissn
1873-2518pii
S0264-410X(10)00500-1journal_volume
28pub_type
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