Soluble recombinant human metapneumovirus G protein is immunogenic but not protective.

Abstract:

:Human metapneumovirus (HMPV) expresses the major surface glycoproteins F and G. We evaluated the protective efficacy of immunization with G. We generated a recombinant form of G ectodomain (GDeltaTM) that was secreted from mammalian cells and purified by affinity chromatography. We tested the immunogenicity of GDeltaTM in cotton rats. Animals were immunized with PBS, GDeltaTM alone or adjuvanted, or were infected once with HMPV, and challenged with live HMPV at 28 days. Animals vaccinated with adjuvanted and non-adjuvanted GDeltaTM developed high levels of serum antibodies to both recombinant and native G protein; however, vaccinated animals did not develop neutralizing antibodies and were not protected against virus challenge. Unlike the analogous non-fusion glycoproteins of other human paramyxoviruses, HMPV G does not appear to be a protective antigen. This represents an unusual feature of HMPV.

journal_name

Vaccine

journal_title

Vaccine

authors

Ryder AB,Tollefson SJ,Podsiad AB,Johnson JE,Williams JV

doi

10.1016/j.vaccine.2010.04.007

subject

Has Abstract

pub_date

2010-06-07 00:00:00

pages

4145-52

issue

25

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)00500-1

journal_volume

28

pub_type

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