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A recombinant vaccinia-rabies virus in the immunocompromised host: oral innocuity, progressive parenteral infection, and therapeutics.

Abstract：

:With the emergence of raccoons (Procyon lotor) as the primary rabies reservoir in the United States of America, a recombinant vaccinia-rabies glycoprotein (V-RG) virus vaccine was developed that protected raccoons by the oral route from rabies infection. Despite extensive laboratory evaluation, vaccine safety concerns remained about free-choice distribution for wildlife rabies control. In this study, the oral innocuity of V-RG virus was demonstrated in immunodeficient mice but parenteral exposure resulted in systemic and progressive infection, albeit significantly abrogated in severity in comparison to vaccinia virus. Treatment with vaccinia immune globulin and hydroxyphosphonylmethoxy-propyl-cytosine resulted in significantly longer survival and minimized V-RG viral gross lesions.

journal_name

Vaccine

journal_title

Vaccine

authors

Hanlon CA,Niezgoda M,Shankar V,Niu HS,Koprowski H,Rupprecht CE

doi

10.1016/s0264-410x(96)00163-6

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

140-8

issue

2

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(96)00163-6

journal_volume

15

pub_type

杂志文章

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