Abstract：
:To examine boostering of varicella zoster virus (VZV)-specific immunity in seropositive adults after nasal inhalation of heat-inactivated or live attenuated varicella vaccine, we determined specific cellular immunity, IgG antibody in sera and secretory IgA antibody in saliva before and after the inhalation. The mean titers in specific IgG antibody and skin test findings significantly increased following inhalation of both vaccines. However, the ratio of a two-fold or more increase in the levels of IgG antibody or skin test did not show significant difference after inhalation of the inactivated vaccine in comparison with those in the control. After inhalation of the live vaccine, the ratio showed significant difference but transmission of the live vaccine virus to others was suspected. No significant increase in VZV-secretory IgA antibody levels in saliva was noted following inhalation. The results of this study suggested that nasal inhalation of the live vaccine could increase specific immunity in adults. This method would be similar to the natural infection and simpler than subcutaneous injection.
journal_name
Vaccinejournal_title
Vaccineauthors
Terada K,Niizuma T,Ogita S,Kataoka Ndoi
10.1016/s0264-410x(02)00408-5subject
Has Abstractpub_date
2002-11-01 00:00:00pages
3638-43issue
31-32eissn
0264-410Xissn
1873-2518pii
S0264410X02004085journal_volume
20pub_type
杂志文章相关文献
VACCINE文献大全abstract：OBJECTIVES:With the re-emergence of chikungunya virus (CHIKV) in an explosive form and in the absence of a commercially available vaccine, we aimed to develop candidate vaccines employing recombinant E2 protein or chemically inactivated whole virus. DESIGN AND METHODS:E2 gene of CHIKV isolate of ECSA genotype was clon...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.07.072
更新日期：2012-09-21 00:00:00
abstract：:From 1983 to 1993 two anti-hepatitis B vaccinal strategies were adopted in two small towns of Southern Italy at high incidence for HBV infections: Afragola (prevalence of HBsAg carriers of 13.4%) and Frattamaggiore (prevalence of HBsAg carriers of 12.9%). In Afragola, the universal vaccination of infants in their firs...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/0264-410x(95)00056-7
更新日期：1995-09-01 00:00:00
abstract：:Porcine circovirus type-2b (PCV2b) is the primary global causative agent of porcine circovirus-associated disease (PCVAD). In this study, we first constructed a novel chimeric virus (PCV1-2b) with the PCV2b capsid gene cloned into the backbone of non-pathogenic PCV1. A pathogenicity study conducted in caesarean-derive...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.10.050
更新日期：2010-12-16 00:00:00
abstract：:In July of 2014, a symposium entitled "Enhancing Vaccine Immunity and Value" was held in Siena, Italy. The focus of the symposium was on how to best meet the challenge of developing and implementing vaccines for future disease targets. Vaccination has been responsible for averting estimated 3 billion cases of disease ...
journal_title：Vaccine
pub_type： 社论
doi：10.1016/j.vaccine.2015.02.072
更新日期：2015-06-08 00:00:00
abstract：:A safety requirement for live vaccines is investigating possible shedding in recipients since the presence of replication competent vaccine in secretions could result in direct and indirect horizontal transmission. This is especially relevant for oral rabies vaccine baits that are deliberately distributed into the env...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.12.076
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:Implementing national-level vaccination programs involves long-term investment, which can be a significant financial burden, particularly in resource-limited settings. Although many studies have assessed the economic impacts of providing vaccinations, evidence on the positive and negative implications of huma...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.08.014
更新日期：2016-09-14 00:00:00
abstract：:These studies were performed to determine the effects of GPI-0100, a semi synthetic Quillaja Saponin analog, formulated with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) on immunity to HSV. SKH-1 hairless mice, used as a model of herpes labialis, inoculated with HSV-1 results in facial lesions, virus replic...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.10.017
更新日期：2006-03-06 00:00:00
abstract：INTRODUCTION:Adolescents and young adults are at a high risk of developing human papillomavirus (HPV) infections, which can be prevented with the use of vaccines. Moreover, a combined immunization strategy for administration of HPV vaccines with other routine vaccines may lead to better compliance. We aim to comprehens...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2019.10.092
更新日期：2020-01-10 00:00:00
abstract：:The baculovirus-insect cell expression system is a well known tool for the production of complex proteins. The technology is also used for commercial manufacture of various veterinary and human vaccines. This review paper provides an overview of how this technology can be applied to produce a multitude of vaccine cand...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2012.01.016
更新日期：2012-02-27 00:00:00
abstract：:Streptococcus suis (S. suis) is a major porcine pathogen causing meningitis, arthritis and several other pathologies. Recently, we identified a highly specific immunoglobulin M degrading enzyme of S. suis, designated IdeSsuis, which is expressed by various serotypes. The objective of this work was to access the immuno...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.03.047
更新日期：2015-05-05 00:00:00
abstract：:Influenza virus hemagglutinin (HA) and neuraminidase (NA) proteins elicit protective antibody responses and therefore, are used as targets for vaccination, especially the HA protein. However, these proteins are subject to antigenic drift, decreasing vaccine efficacy, and few to no studies have analyzed antigenic varia...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.09.005
更新日期：2018-10-15 00:00:00
abstract：:The World Health Organization's Expanded Programme on Immunization has led to a dramatic rise in worldwide vaccination rates over the past 40years, yet 19.4 million infants remain underimmunized each year. Many of these infants have received at least one vaccine dose but may remain unprotected because they did not rec...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.05.094
更新日期：2018-05-24 00:00:00
abstract：:Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations w...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00180-8
更新日期：2000-10-15 00:00:00
abstract：:The level of antibody production induced by a vaccine involves a variety of host factors. One of these, insulin-like growth factor-1 (IGF-1), plays an important role in lymphocyte maturation and antibody expression. Here, we investigated the role of macrophage-derived IGF-1 in the induction of influenza vaccine-specif...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.07.037
更新日期：2017-08-24 00:00:00
abstract：:We sought to determine the vaccine effectiveness (VE) of Lanzhou lamb rotavirus (LLR) vaccine against rotavirus gastroenteritis in children <5 requiring hospitalization. Children hospitalized 2002-2004 with rotavirus gastroenteritis were matched by gender, age and community to 838 controls. VE was calculated for one o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.10.036
更新日期：2007-12-17 00:00:00
abstract：BACKGROUND:Patients with chronic kidney disease (CKD) often fail to produce protective antibodies to hepatitis B virus (HBV) surface antigen after vaccination. Diabetes mellitus (DM) is the most common cause of CKD; however it is not clear whether it affects immunological response to HBV vaccine in these patients. AIM...
journal_title：Vaccine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.vaccine.2010.03.038
更新日期：2010-05-14 00:00:00
abstract：:The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon alpha-2b (rIFNalpha-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized contro...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2010.03.062
更新日期：2010-06-17 00:00:00
abstract：:Neisseria meningitidis is an important cause of bacterial meningitis and septicaemia with most disease caused by meningococci bearing serogroups A, B, C, Y and W-135 polysaccharides. Monovalent serogroup C conjugate vaccines have become established in the immunisation programmes in many countries and the first quadriv...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2009.05.003
更新日期：2009-06-24 00:00:00
abstract：:HIV infection is characterized by chronic immune activation and the establishment of a pool of latently infected cells. Antiretroviral therapy (ART) can suppress viral load to undetectable levels in peripheral blood by standard measure, however immune activation/chronic inflammation and latent infection persist and af...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.04.015
更新日期：2020-06-02 00:00:00
abstract：:In chronic Hepatitis B Virus (HBV) infection the function of dendritic cells (DC), T- and B-cells is impaired. DC vaccination is an option to overcome this. DC pulsed in vitro with HBV sub viral particles (HBVsvp) and used to immunize mice can activate HBV directed humoral and cellular immune responses. In the present...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.07.057
更新日期：2012-09-14 00:00:00
abstract：:As more HIV-1 infected patients receive anti-retroviral drug treatment, the occurrence of drug-resistant variants of the virus is increasing. We have previously shown that mutated HIV peptide sequences represent mutations induced by antiretroviral drugs are equally good and often better immunogens than wild type pepti...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.03.096
更新日期：2008-09-19 00:00:00
abstract：BACKGROUND:23-Valent pneumococcal polysaccharide vaccine, trade name Pneumovax(®)23 (PPSV23), has been used for decades in the Unites States and has an extensive clinical record. However, limited post-licensure safety assessment has been conducted. OBJECTIVE:To analyze reports submitted to the Vaccine Adverse Event Re...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.04.021
更新日期：2016-05-27 00:00:00
abstract：:Codon-pair bias de-optimization (CPBD) of viruses involves re-writing viral genes using statistically underrepresented codon pairs, without any changes to the amino acid sequence or codon usage. Previously, this technology has been used to attenuate the influenza A/Puerto Rico/8/34 (H1N1) virus. The de-optimized virus...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.11.054
更新日期：2016-01-20 00:00:00
abstract：BACKGROUND:Each year, approximately 1,066 Cambodian children under five years old die of diarrhea, and 51% of these deaths are due to rotavirus gastroenteritis. Quantifying childhood hospitalizations caused by severe rotavirus infections is also important in demonstrating disease burden caused by this virus. The object...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.03.032
更新日期：2018-12-14 00:00:00
abstract：:Recent studies have revealed that the interface of gp120 and gp41 and some parts of gp41 are also critical epitopes for elicitation of broadly neutralizing antibodies. Therefore, potential trimeric gp41 or gp140 immunogen candidates are needed. Previously, we developed a trimer motif MTQ and demonstrated that it could...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.09.077
更新日期：2020-11-03 00:00:00
abstract：:Binding of antibodies to oligomeric envelope glycoprotein of R5-tropic primary isolates of human immunodeficiency virus type 1 (HIV-1) was studied by flow cytometry using sera from HIV-1 vaccine recipients and clade B and C HIV-1-infected patients, and monoclonal and polyclonal antibodies to neutralizing epitopes of H...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.07.013
更新日期：2004-01-02 00:00:00
abstract：:Influenza becomes epidemic worldwide every year, and many individuals receive vaccination annually. Quality control relating to safety and potency of influenza vaccines is important to maintain public confidence. The safety of influenza vaccines has been assessed by clinical trials, and animal safety tests are perform...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.09.021
更新日期：2018-10-15 00:00:00
abstract：BACKGROUND:Following primary vaccination of adults ⩾65years of age with 23-valent pneumococcal polysaccharide vaccine (PPSV23), immune responses increase and thereafter appear to decrease over time. With increased life expectancy worldwide, revaccination with PPSV23 may be required for continued protection of the elder...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.vaccine.2016.05.052
更新日期：2016-07-19 00:00:00
abstract：:In Russia, live vaccine strains Brucella abortus 82 and B. abortus 75/79-AV have been widely and extensively utilized for specific prophylaxis of cattle brucellosis. To differentiate these vaccine strains from each other and laboratory collection of other vaccine (n=4), reference (n=15) and field Brucella strains (n=6...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.03.051
更新日期：2010-10-01 00:00:00
abstract：INTRODUCTION:One of the goals of the Global Measles and Rubella Strategic Plan is the reduction in global measles mortality, with high measles vaccination coverage as one of its core components. While measles mortality has been reduced more than 79%, the disease remains a major cause of childhood vaccine preventable di...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.09.038
更新日期：2017-10-27 00:00:00
