Quadrivalent meningococcal conjugate vaccines.

abstract：BACKGROUND:The development of a vaccine against the human gastric pathogen Helicobacter pylori, the main causative agent of gastric adenocarcinoma, has been hampered by a number of issues, including the lack of a mucosal adjuvant for use in humans. Heat shock proteins (Hsp), highly conserved molecules expressed by both...

journal_title：Vaccine

authors： Chionh YT,Arulmuruganar A,Venditti E,Ng GZ,Han JX,Entwisle C,Ang CS,Colaco CA,McNulty S,Sutton P

更新日期：2014-04-25 00:00:00

abstract：:The unique genetic makeup and remarkable competency of Vibrio cholerae are the key factors that help the cholera pathogen adapt rapidly to adverse environmental conditions and resist the detrimental effect of antimicrobial agents. In the last few decades, V. cholerae that causes acute watery diarrhoeal disease cholera...

journal_title：Vaccine

authors： Das B,Verma J,Kumar P,Ghosh A,Ramamurthy T

更新日期：2020-02-29 00:00:00

abstract：:When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpr...

journal_title：Vaccine

authors： Smeeth L,Rodrigues LC,Hall AJ,Fombonne E,Smith PG

更新日期：2002-06-07 00:00:00

abstract：:The growth of Mycobacterium w, a candidate strain for leprosy vaccine in submerged culture, was inhibited by the presence of over 40% oxygen saturation in the medium. Intracellular levels of superoxide dismutase and catalase were very low in the beginning. However, under controlled oxygenation, these levels increased ...

journal_title：Vaccine

authors： Mukhopadhyay A,Panda AK,Pandey AK

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:The Polio Endgame strategy includes phased withdrawal of oral poliovirus vaccines (OPV) coordinated with introduction of inactivated poliovirus vaccine (IPV) to ensure population immunity. The impact of IPV introduction into a primary OPV series of immunizations in a developing country is uncertain. METHODS...

journal_title：Vaccine

authors： Mychaleckyj JC,Haque R,Carmolli M,Zhang D,Colgate ER,Nayak U,Taniuchi M,Dickson D,Weldon WC,Oberste MS,Zaman K,Houpt ER,Alam M,Kirkpatrick BD,Petri WA Jr

更新日期：2016-01-12 00:00:00

abstract：:Dengue is one of the most important mosquito-borne viral disease causing dengue fever and/or dengue shock syndrome/haemorrhagic fever. In some reports, the non-structural protein 1 (NS1) has been identified as a promising antigen for the development of vaccines against dengue virus (DENV). Apparently, it can elicit a ...

journal_title：Vaccine

authors： Costa SM,Freire MS,Alves AM

更新日期：2006-05-22 00:00:00

abstract：BACKGROUND:Vaccination uptake at the individual level can be assessed in a variety of ways, including traditional measures of being up-to-date (UTD), measures of UTD that consider dose timing, like age-appropriate vaccination, and risk reduction from individual doses. This analysis compared methods of operationalizing ...

journal_title：Vaccine

authors： Goldstein ND,Newbern EC,Evans AA,Drezner K,Welles SL

更新日期：2015-07-31 00:00:00

abstract：:Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain facilities. This is advantageous for mass...

journal_title：Vaccine

authors： Thakur A,Ingvarsson PT,Schmidt ST,Rose F,Andersen P,Christensen D,Foged C

更新日期：2018-05-31 00:00:00

abstract：:Human papillomavirus type 16 (HPV16)-transformed mouse TC-1 cells are extensively used in the evaluation of efficacy of experimental vaccines against tumours induced by HPVs. As these cells strongly express MHC class I molecules and downregulation of MHC class I surface expression is one of the important mechanisms th...

journal_title：Vaccine

authors： Smahel M,Síma P,Ludvíková V,Marinov I,Pokorná D,Vonka V

更新日期：2003-03-07 00:00:00

abstract：:Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute encephalitis with high mortality in humans. To understand the virus-host interactions that influence JEV virulence, we determined the lethality of a neurovirulent (RP-9) and an attenuated (RP-2ms) variant of JEV in several immunodeficie...

journal_title：Vaccine

authors： Liang JJ,Liao CL,Liao JT,Lee YL,Lin YL

更新日期：2009-05-11 00:00:00

abstract：:Pre-fusion stabilizing mutations (DS-Cav1) in soluble fusion (F) proteins of human respiratory syncytial virus (RSV) were previously reported. Here we investigated the antigenic and immunogenic properties of pre-fusion like RSV F proteins on enveloped virus-like particles (VLP). Additional mutations were introduced to...

journal_title：Vaccine

authors： Kwon YM,Lee Y,Kim KH,Jung YJ,Li Z,Jeeva S,Lee S,Moore ML,Kang SM

更新日期：2019-10-16 00:00:00

abstract：:Numerous evidence demonstrate Type 1 diabetes (T1D) is due to a loss of immune tolerance to islet antigens, and CD8(+) T cells play an important role in the development of T1D in NOD mice. The novel coinhibitory receptor BTLA may have a regulatory role in maintaining peripheral tolerance, however, its role in autoimmu...

journal_title：Vaccine

authors： Li S,Zhang M,Xiang F,Zhao J,Jiang C,Zhu J

更新日期：2011-10-13 00:00:00

abstract：:The IgG isotype response in Balb/c mice infected with FMDV or immunized with different vaccine formulations using inactivated virus particles as antigen was analyzed at various times post-inoculation. For this purpose an ELISA based on polyclonal antibodies for detection and quantification of mouse IgG isotypes with F...

journal_title：Vaccine

authors： Pérez Filgueira DM,Berinstein A,Smitsaart E,Borca MV,Sadir AM

更新日期：1995-07-01 00:00:00

abstract：:There is a growing public health interest in controlling sexually transmitted infections (STIs) through vaccination due to increasing recognition of the global disease burden of STIs and the role of STIs in women's reproductive health, adverse pregnancy outcomes, and the health and well-being of neonates. Neisseria go...

journal_title：Vaccine

authors： Vincent LR,Jerse AE

更新日期：2019-11-28 00:00:00

abstract：:We have developed the Mycobacterium tuberculosis (Mtb) fusion protein (ID83), which contains the three Mtb proteins Rv1813, Rv3620 and Rv2608. We evaluated the immunogenicity and protective efficacy of ID83 in combination with several emulsion-formulated toll-like receptor agonists. The ID83 subunit vaccines containin...

journal_title：Vaccine

authors： Baldwin SL,Bertholet S,Kahn M,Zharkikh I,Ireton GC,Vedvick TS,Reed SG,Coler RN

更新日期：2009-05-18 00:00:00

abstract：:Ebola virus (EBOV) is among the deadliest pathogens known to man causing infrequent outbreaks of hemorrhagic disease. In humans, the case fatality rates in the outbreaks can reach 90%. During the West African epidemic almost 30,000 people were infected and of these over 11,000 fatalities were reported. Currently, we a...

journal_title：Vaccine

authors： Lehrer AT,Wong TS,Lieberman MM,Johns L,Medina L,Feldmann F,Feldmann H,Marzi A

更新日期：2019-11-08 00:00:00

abstract：:The predominant route of HIV infection is through the sexual transmission via M cells. Most of the peptide and protein vaccines show poor transport across the epithelial barrier and are commonly administered by parenteral route. In the present study four HIV peptides from envelope (gp 41-LZ (leucine zipper), gp 41-FD ...

journal_title：Vaccine

authors： Manocha M,Pal PC,Chitralekha KT,Thomas BE,Tripathi V,Gupta SD,Paranjape R,Kulkarni S,Rao DN

更新日期：2005-12-01 00:00:00

abstract：:The 9th African rotavirus symposium was held in Maputo, Mozambique from the 8th to 10th of December 2015, including a total of 101 delegates from 17 countries, 15 of which were African countries. This forum brought together participants with various expertise including scientists, clinicians, immunization program mana...

journal_title：Vaccine

authors： Mandomando I,Weldegebriel G,de Deus N,Mwenda JM

更新日期：2017-03-23 00:00:00

abstract：:Prevalence of non-typeable Haemophilus influenzae (NTHi) in the etiology of invasive infections in immunocompromised individuals is increasing. Serum IgG antibody levels to H. influenzae protein D (PD) were significantly lower in adults suffering from chronic conditions causing secondary immunodeficiency (COPD, cancer...

journal_title：Vaccine

authors： Hawdon N,Biman B,McCready W,Brigden M,Malik S,Vergidis D,Kisselgoff O,Ulanova M

更新日期：2012-02-08 00:00:00

abstract：:Foot-and-mouth disease (FMD) is a highly contagious vesicular disease that affects domestic and wild cloven-hoofed animals worldwide. Recently, a series of outbreaks of type A FMDV occurred in Southeast Asian countries, China, the Russia Federation, Mongolia, Kazakhstan and South Korea. The FMD virus (A/GDMM/CHA/2013)...

journal_title：Vaccine

authors： Zheng H,Lian K,Yang F,Jin Y,Zhu Z,Guo J,Cao W,Liu H,He J,Zhang K,Li D,Liu X

更新日期：2015-10-26 00:00:00

abstract：:Serotype-specific protective immunity in pediatric patients with invasive pneumococcal disease (IPD) has not been fully investigated. To determine the protective immunity to the infecting serotype, the serotype-specific immunoglobulin G (IgG) levels and opsonization indices (OIs) were examined in 24 Japanese pediatric...

journal_title：Vaccine

authors： Oishi T,Ishiwada N,Matsubara K,Nishi J,Chang B,Tamura K,Akeda Y,Ihara T,Nahm MH,Oishi K,Japanese IPD Study Group.

更新日期：2013-01-21 00:00:00

abstract：:Infection with influenza virus during pregnancy poses a significant risk of complications for both mother and fetus. During the H1N1 2009 pandemic, pregnant women constituted one of the priority groups for vaccination in many countries, creating a need for close monitoring of the safety of the vaccine in pregnant wome...

journal_title：Vaccine

authors： Tavares F,Nazareth I,Monegal JS,Kolte I,Verstraeten T,Bauchau V

更新日期：2011-08-26 00:00:00

abstract：:Seasonal influenza epidemics represent a substantial public health burden, causing significant morbidity and mortality. Influenza in humans can be caused by influenza type A and type B viruses, and although influenza A is responsible for the majority of seasonal influenza infections, influenza B disease is common in c...

journal_title：Vaccine

authors： Belshe RB

更新日期：2010-09-07 00:00:00

abstract：:Classical swine fever virus (CSFV) causes significant losses in pig industry in many countries in Asia and Europe. The E2 glycoprotein of CSFV is the main target for neutralizing antibodies. Recently, the replicon of alphaviruses, such as Semliki Forest virus (SFV), has been developed as replicative expression vectors...

journal_title：Vaccine

authors： Li N,Qiu HJ,Zhao JJ,Li Y,Wang MJ,Lu BW,Han CG,Hou Q,Wang ZH,Gao H,Peng WP,Li GX,Zhu QH,Tong GZ

更新日期：2007-04-12 00:00:00

abstract：:In clinical trials, the specificity of the disease endpoint is critical to an accurate estimate of vaccine efficacy. We used a logistic regression model to analyse parasite densities among children before and after treatment with antimalarials, in order to estimate the impact that clearing asymptomatic parasitaemia ha...

journal_title：Vaccine

authors： Bejon P,Mwangi T,Lowe B,Peshu N,Hill AV,Marsh K

更新日期：2007-11-23 00:00:00

abstract：:A phase III, randomized, double-blind study evaluated the efficacy, reactogenicity, safety and immunogenicity of a human rotavirus vaccine, RIX4414 in Japanese infants aged 6-14 weeks when administered as two doses (0, 1-month schedule). Efficacy against any and severe rotavirus gastroenteritis leading to medical inte...

journal_title：Vaccine

authors： Kawamura N,Tokoeda Y,Oshima M,Okahata H,Tsutsumi H,Van Doorn LJ,Muto H,Smolenov I,Suryakiran PV,Han HH

更新日期：2011-08-26 00:00:00

abstract：:Influenza is a zoonotic disease caused by a constantly varying RNA virus resulting in a need for continuous surveillance to update human vaccines. Our knowledge indicates that the intermittent pandemics of influenza originate from influenza viruses or gene segments from influenza viruses in lower animals and birds. Th...

journal_title：Vaccine

authors： Webster RG

更新日期：2002-05-15 00:00:00

abstract：:CD8(+) T-cell responses provide beneficial antiviral immunity against human immunodeficiency virus 1 (HIV-1). In this study, we show that intragastric vaccination with a Salmonella HIV-1 Env DNA vaccine vector generates Env-specific CD8(+) T-cells, both in mucosal and systemic lymphoid tissue. By contrast, intramuscul...

journal_title：Vaccine

authors： Shata MT,Reitz MS Jr,DeVico AL,Lewis GK,Hone DM

更新日期：2001-11-12 00:00:00

abstract：:Vesicular stomatitis virus (VSV) has been extensively utilized as a viral vector system for the induction of protective immune responses against a variety of pathogens. We constructed recombinant VSVs specifying either the Indiana or Chandipura virus G glycoprotein and expressing the West Nile virus (WNV) envelope (E)...

journal_title：Vaccine

authors： Iyer AV,Pahar B,Boudreaux MJ,Wakamatsu N,Roy AF,Chouljenko VN,Baghian A,Apetrei C,Marx PA,Kousoulas KG

更新日期：2009-02-05 00:00:00

abstract：:The main objective of this study was to assess the efficacy of a monovalent inactivated vaccine containing phase I Coxiella burnetii to prevent Coxiella shedding in susceptible dairy cows within infected herds in comparison to a placebo. A total of 336 dairy cows and heifers, from six spontaneously infected herds, wer...

journal_title：Vaccine

authors： Guatteo R,Seegers H,Joly A,Beaudeau F

更新日期：2008-08-12 00:00:00