Abstract:
:Binding of antibodies to oligomeric envelope glycoprotein of R5-tropic primary isolates of human immunodeficiency virus type 1 (HIV-1) was studied by flow cytometry using sera from HIV-1 vaccine recipients and clade B and C HIV-1-infected patients, and monoclonal and polyclonal antibodies to neutralizing epitopes of HIV-1. Vaccine recipients received recombinant canarypox virus vaccine expressing HIV-1 gene products, and SF-2 recombinant gp120 subunit vaccine. Anti-gp120 neutralizing antibodies including human monoclonal antibody 2G12 and goat polyclonal anti-serum to V3 loop peptide [peptide T1-SP10MN(A)] bound to HIV-1-infected cells. Sera from vaccine recipients bound to HIV-1-infected cells, but at levels lower than did infected patient sera.
journal_name
Vaccinejournal_title
Vaccineauthors
Gorse GJ,Patel GB,Arbuckle JA,Belshe RBdoi
10.1016/j.vaccine.2003.07.013subject
Has Abstractpub_date
2004-01-02 00:00:00pages
383-97issue
3-4eissn
0264-410Xissn
1873-2518pii
S0264410X03005991journal_volume
22pub_type
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