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Immunogenicity and reactogenicity in UK infants of a novel meningococcal vesicle vaccine containing multiple class 1 (PorA) outer membrane proteins.

Abstract：

:The development of effective vaccines against serogroup B meningococci is of great public health importance. We assessed a novel genetically engineered vaccine containing six meningococcal class 1 (PorA) outer membrane proteins representing 80% of prevalent strains in the UK. 103 infants were given the meningococcal vaccine at ages 2, 3 and 4 months with routine infant immunisations, with a fourth dose at 12-18 months. The vaccine was well tolerated. Three doses evoked good immune responses to two of six meningococcal strains expressing PorA proteins contained in the vaccine. Following a fourth dose, larger bactericidal responses to all six strains were observed, suggesting that the initial course had primed memory lymphocytes and revaccination stimulated a booster response. This hexavalent PorA meningococcal vaccine was safe and evoked encouraging immune responses in infants. Vaccines of this type warrant further development and evaluation.

journal_name

Vaccine

journal_title

Vaccine

authors

Cartwright K,Morris R,Rümke H,Fox A,Borrow R,Begg N,Richmond P,Poolman J

doi

10.1016/s0264-410x(99)00044-4

subject

Has Abstract

pub_date

1999-06-04 00:00:00

pages

2612-9

issue

20-21

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(99)00044-4

journal_volume

17

pub_type

杂志文章

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