Homotopes affect primary and secondary antibody responses in poultry.

abstract：:Typhoid vaccination is recommended in the United States before travel to countries where typhoid fever is endemic, though little information is available on its effectiveness in travelers. We estimated typhoid vaccination effectiveness (VE) by comparing vaccination status in cases of typhoid fever and paratyphoid feve...

journal_title：Vaccine

authors： Mahon BE,Newton AE,Mintz ED

更新日期：2014-06-17 00:00:00

abstract：:GPI-0100 is a semi-synthetic saponin with modifications designed to augment stability and diminish toxicity. Two batches of GPI-0100 (the second with higher purity) were tested with doses ranging between 100 and 5000 microg in groups of five treated prostate cancer patients who had no evidence of disease except for ri...

journal_title：Vaccine

authors： Slovin SF,Ragupathi G,Fernandez C,Jefferson MP,Diani M,Wilton AS,Powell S,Spassova M,Reis C,Clausen H,Danishefsky S,Livingston P,Scher HI

更新日期：2005-05-02 00:00:00

abstract：:The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...

journal_title：Vaccine

authors： Hermsen CC,Verhage DF,Telgt DS,Teelen K,Bousema JT,Roestenberg M,Bolad A,Berzins K,Corradin G,Leroy O,Theisen M,Sauerwein RW

更新日期：2007-04-12 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of the monovalent rotavirus vaccine (RV1) to prevent rotavirus diarrhea admissions to emergency departments (ED) in Colombia. METHODS:A multicenter case-control study was carried out in six Colombian cities from 2011 to January, 2013. Cases were laboratory confirmed rotavirus diar...

journal_title：Vaccine

authors： Cotes-Cantillo K,Paternina-Caicedo A,Coronell-Rodríguez W,Alvis-Guzmán N,Parashar UD,Patel M,De la Hoz-Restrepo F

更新日期：2014-05-23 00:00:00

abstract：:Extending the benefits of vaccination to everyone who is eligible requires an understanding of which populations current vaccination efforts have struggled to reach. A clear definition of "hard-to-reach" populations - also known as high-risk or marginalized populations, or reaching the last mile - is essential for est...

journal_title：Vaccine

authors： Ozawa S,Yemeke TT,Evans DR,Pallas SE,Wallace AS,Lee BY

更新日期：2019-09-03 00:00:00

abstract：:Live-attenuated influenza vaccine (LAIV) delivered by large droplet intranasal spray is efficacious against infection. However, many of the large droplets are trapped in the external nares and do not reach the target nasal airway tissues. Smaller droplets might provide better distribution yielding similar protection w...

journal_title：Vaccine

authors： Smith JH,Brooks P,Johnson S,Tompkins SM,Custer KM,Haas DL,Mair R,Papania M,Tripp RA

更新日期：2011-03-21 00:00:00

abstract：BACKGROUND:The safety and tolerability of Flublok(®), a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA(®) in a randomized, blinded clinical trial in adults ≥ 50 years of age with attention to hypersensitivity reactions. METHODS:This blinded, randomized trial of healthy adults ≥ ...

journal_title：Vaccine

authors： Izikson R,Leffell DJ,Bock SA,Patriarca PA,Post P,Dunkle LM,Cox MM

更新日期：2015-11-27 00:00:00

abstract：:Modified Vaccinia virus Ankara (MVA) is an attenuated strain of vaccinia virus that is being considered as a safer alternative to replicating vaccinia vaccine strains such as Dryvax(®) and ACAM2000. Its excellent safety profile and large genome also make it an attractive vector for the delivery of heterologous genes f...

journal_title：Vaccine

authors： Hermanson G,Chun S,Felgner J,Tan X,Pablo J,Nakajima-Sasaki R,Molina DM,Felgner PL,Liang X,Davies DH

更新日期：2012-01-11 00:00:00

abstract：:Meningococcal disease is a serious public health threat given the seriousness of the illness, its disabling sequelae and its potential for epidemic spread. The disease is a concern during mass gatherings which provide conditions that facilitate transmission of infectious agents including Neisseria meningitidis. Implem...

journal_title：Vaccine

authors： Yezli S,Gautret P,Assiri AM,Gessner BD,Alotaibi B

更新日期：2018-07-25 00:00:00

abstract：:To inform World Health Organization recommendations regarding use of Haemophilus influenzae type b (Hib) vaccines in national immunization programs, a multi-country evaluation of trends in Hib meningitis incidence and prevalence of nasopharyngeal Hib carriage was conducted in four South American countries using either...

journal_title：Vaccine

authors： Garcia S,Lagos R,Muñoz A,Picón T,Rosa R,Alfonso A,Abriata G,Gentile A,Romanin V,Regueira M,Chiavetta L,Agudelo CI,Castañeda E,De la Hoz F,Higuera AB,Arce P,Cohen AL,Verani J,Zuber P,Gabastou JM,Pastor D,Flannery

更新日期：2012-01-05 00:00:00

abstract：:Clinical leprosy is characterized by varying manifestations between tuberculoid and lepromatous leprosy. In the former state the patient is able to elicit a cell-mediated immune response whereas in the latter, there is usually a humoral response. An understanding of this immunological balance is crucial in the search ...

journal_title：Vaccine

authors： Stewart-Tull DE

更新日期：1984-12-01 00:00:00

abstract：:Our initial results with a bovine papilloma virus (BPV) vector expression system indicated that we could produce significant amounts of Epstein-Barr virus (EBV) gp340/220 in the supernatant of a mouse fibroblast cell line. We have now extended these findings to show that the truncated version of gp340/220, where the m...

journal_title：Vaccine

authors： Madej M,Conway MJ,Morgan AJ,Sweet J,Wallace L,Qualtiere LF,Arrand JR,Mackett M

更新日期：1992-01-01 00:00:00

abstract：:To assess the efficacy of the intradermal route of administration of hepatitis A vaccine we conducted a study in hospital laboratory workers. Forty-three volunteers were given three different combinations of intradermal and intramuscular hepatitis A vaccine and compared with 18 controls given intramuscular vaccine onl...

journal_title：Vaccine

authors： Brindle RJ,Morris CA,Berger R,Kurtz JB

更新日期：1994-05-01 00:00:00

abstract：:Evidence that influenza vaccination during pregnancy is safe and effective at preventing influenza disease in women and their children through the first months of life is increasing. Several reports of reduced risk of adverse outcomes associated with influenza vaccination have generated interest in its potential for i...

journal_title：Vaccine

authors： Savitz DA,Fell DB,Ortiz JR,Bhat N

更新日期：2015-11-25 00:00:00

abstract：:A recombinant Lactobacillus casei expressing a flagellar antigen from Salmonella enterica serovar Enteritidis was constructed and evaluated as a mucosal vaccine. Intragastric immunization of the recombinant strain conferred protective immunity against Salmonella infection in mice. This immunization did not result in a...

journal_title：Vaccine

authors： Kajikawa A,Satoh E,Leer RJ,Yamamoto S,Igimi S

更新日期：2007-05-04 00:00:00

abstract：:The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix(®)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n=611) were randomised (3:1:1) to receive ...

journal_title：Vaccine

authors： Østergaard L,Silfverdal SA,Berglund J,Flodmark CE,West C,Bianco V,Baine Y,Miller JM

更新日期：2012-01-17 00:00:00

abstract：:We have recently shown that immunization against the extra domain-B (ED-B) of fibronectin, using Freund's adjuvant, reduces tumor growth in mice by 70%. In the present study we compare the immune response generated against ED-B using the non-toxic and biodegradable adjuvant Montanide ISA 720/CpG with the response elic...

journal_title：Vaccine

authors： Huijbers EJ,Femel J,Andersson K,Björkelund H,Hellman L,Olsson AK

更新日期：2012-01-05 00:00:00

abstract：BACKGROUND:This study examined the transmissibility between young children of an intranasally administered live attenuated human parainfluenza virus type 3 (HPIV3)-cp45 vaccine candidate. METHODS:Eighty subjects were enrolled in playgroups among whom there was at least one infected vaccinee in close contact with a ser...

journal_title：Vaccine

authors： Madhi SA,Cutland C,Zhu Y,Hackell JG,Newman F,Blackburn N,Murphy BR,Belshe RB,Karron RA,Deatly AM,Gruber WC,Bernstein DI,Wright PF

更新日期：2006-03-20 00:00:00

abstract：:Modified vaccinia Ankara (MVA) recombinants expressing single or multiple RSV surface proteins (F or G) are promising potential vaccines. We studied humoral and cellular responses induced by MVA-F and MVA-G in mice, comparing them to a formalin inactivated RSV preparation (FI-RSV) known to increase disease severity. M...

journal_title：Vaccine

authors： Olszewska W,Suezer Y,Sutter G,Openshaw PJ

更新日期：2004-11-25 00:00:00

abstract：:The development of effective vaccines against serogroup B meningococci is of great public health importance. We assessed a novel genetically engineered vaccine containing six meningococcal class 1 (PorA) outer membrane proteins representing 80% of prevalent strains in the UK. 103 infants were given the meningococcal v...

journal_title：Vaccine

authors： Cartwright K,Morris R,Rümke H,Fox A,Borrow R,Begg N,Richmond P,Poolman J

更新日期：1999-06-04 00:00:00

abstract：:To examine boostering of varicella zoster virus (VZV)-specific immunity in seropositive adults after nasal inhalation of heat-inactivated or live attenuated varicella vaccine, we determined specific cellular immunity, IgG antibody in sera and secretory IgA antibody in saliva before and after the inhalation. The mean t...

journal_title：Vaccine

authors： Terada K,Niizuma T,Ogita S,Kataoka N

更新日期：2002-11-01 00:00:00

abstract：:Formalin-killed Streptococcus difficile strains used as vaccines delivered intraperitoneally were able to protect tilapia against a challenge of 100 LD50. The protection obtained was not strain specific. A vaccine based on an S. difficile extract containing 50% protein conjugated to alum also protected tilapia challen...

journal_title：Vaccine

authors： Eldar A,Shapiro O,Bejerano Y,Bercovier H

更新日期：1995-06-01 00:00:00

abstract：:A booster dose of a formalin-inactivated, cell culture-propagated Rift Valley fever vaccine (TSI-GSD-200) was administered without significant reactogenicity to 60 volunteers 18 months after they received a three dose primary series. Blood was drawn for serological testing prior to boosting and 10, 49, and 180 days th...

journal_title：Vaccine

authors： Kark JD,Aynor Y,Peters CJ

更新日期：1985-06-01 00:00:00

abstract：:Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine develop...

journal_title：Vaccine

authors： Bermúdez A,Calderon D,Moreno-Vranich A,Almonacid H,Patarroyo MA,Poloche A,Patarroyo ME

更新日期：2014-04-11 00:00:00

abstract：:IDU exposure remains a primary driver of the Russian HIV epidemic, and recent incidence data provide little evidence that this epidemic is slowing. While there are multiple important challenges that need to be further explored before starting vaccine trials, most importantly access to evidence-based drug treatment ser...

journal_title：Vaccine

authors： Beyrer C,Baral S,Shaboltas A,Dukhovlinova E,Masharsky A,Verevochkin S,Latkin C,Heimer R,Hoffman I,Kozlov A

更新日期：2007-10-10 00:00:00

abstract：BACKGROUND:The severe acute respiratory syndrome (SARS) virus is a member of the Coronaviridae (CoV) family that first appeared in the Guangdong Province of China in 2002 and was recognized as an emerging infectious disease in March 2003. Over 8000 cases and 900 deaths occurred during the epidemic. We report the safety...

journal_title：Vaccine

authors： Martin JE,Louder MK,Holman LA,Gordon IJ,Enama ME,Larkin BD,Andrews CA,Vogel L,Koup RA,Roederer M,Bailer RT,Gomez PL,Nason M,Mascola JR,Nabel GJ,Graham BS,VRC 301 Study Team.

更新日期：2008-11-25 00:00:00

abstract：:Recent studies have revealed that the interface of gp120 and gp41 and some parts of gp41 are also critical epitopes for elicitation of broadly neutralizing antibodies. Therefore, potential trimeric gp41 or gp140 immunogen candidates are needed. Previously, we developed a trimer motif MTQ and demonstrated that it could...

journal_title：Vaccine

authors： Yao L,Wang JY,Bao LN,Fan MX,Bai Y,Chen WJ,Yuan C,Yuan L,Wang J,Li Y,Zhuang M,Ling H

更新日期：2020-11-03 00:00:00

abstract：:General vaccination with the 7-valent pneumococcal conjugate vaccine was recommended in Germany in July 2006 for all children <2 years. The proportion of reported invasive pneumococcal disease (IPD) caused by vaccine serotypes before vaccine introduction was considerably lower than in the US. We report data from natio...

journal_title：Vaccine

authors： Rückinger S,van der Linden M,Reinert RR,von Kries R,Burckhardt F,Siedler A

更新日期：2009-06-24 00:00:00

abstract：BACKGROUND:Currently, one lifetime booster of a 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for those at highest risk of invasive pneumococcal disease (IPD) 3-5 years after initial vaccination. Due to a lack of evidence on multiple revaccinations, recommendations on repeat revaccination do not ...

journal_title：Vaccine

authors： Caya CA,Boikos C,Desai S,Quach C

更新日期：2015-03-10 00:00:00

abstract：:In this article, we review three mechanisms that contribute to sustaining serum antibody levels: (i) long-lived plasma cells; (ii) persisting or cross-reactive antigen, and (iii) polyclonal activation of all memory B cells. We also present a quantitative analysis of the secondary immune response that reveals the relat...

journal_title：Vaccine

authors： Traggiai E,Puzone R,Lanzavecchia A

更新日期：2003-06-01 00:00:00