Gauche(+) side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine.


:Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. Most of those which did not interfere, compete, inhibit or suppress their individual VHLLAI or FPIPS activity contained or displayed a polyproline II-like (PPIIL) structure when mixed. Here we show that amino acid side-chains located in peptide binding region (PBR) positions p3 and p7 displayed specific electron charges and side-chain gauche(+) orientation for interacting with the TCR. Based on the above, and previously described physicochemical principles, non-interfering, long-lasting, full protection-inducing, multi-epitope, multistage, minimal subunit-based chemically synthesised mHABP mixtures can be designed for developing vaccines against diseases scourging humankind, malaria being one of them.






Bermúdez A,Calderon D,Moreno-Vranich A,Almonacid H,Patarroyo MA,Poloche A,Patarroyo ME




Has Abstract


2014-04-11 00:00:00
















  • The potential cost-effectiveness of acellular pertussis booster vaccination in England and Wales.

    abstract::A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wa...


    pub_type: 杂志文章


    authors: Edmunds WJ,Brisson M,Melegaro A,Gay NJ

    更新日期:2002-01-31 00:00:00

  • A field vaccine trial in Tanzania demonstrates partial protection against malignant catarrhal fever in cattle.

    abstract::Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease of cattle that, in East Africa, results from transmission of the causative virus, alcelaphine herpesvirus 1 (AlHV-1), from wildebeest. A vaccine field trial involving an attenuated AlHV-1 virus vaccine was performed over two wildebeest calving seas...


    pub_type: 杂志文章,随机对照试验


    authors: Lankester F,Russell GC,Lugelo A,Ndabigaye A,Mnyambwa N,Keyyu J,Kazwala R,Grant D,Percival A,Deane D,Haig DM,Cleaveland S

    更新日期:2016-02-03 00:00:00

  • Vaccination of sheep against M. paratuberculosis: immune parameters and protective efficacy.

    abstract::Johne's disease in ruminants is caused by the pathogenic bacterium Mycobacterium avium subspecies paratuberculosis (Map). Currently available Map commercial vaccines protect against clinical disease but not infection. In this study, the proprietary Johne's vaccine Neoparasec and an aqueous formulation of Map 316F (Aqu...


    pub_type: 临床试验,杂志文章


    authors: Begg DJ,Griffin JF

    更新日期:2005-10-10 00:00:00

  • Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis.

    abstract::We hypothesized that the ability of BCG vaccination to protect against Mycobacterium tuberculosis is less in hosts exposed to chronic helminthes infection compared to unexposed individuals. To test this hypothesis we evaluated the efficacy of BCG vaccination in protecting against M. tuberculosis challenge in Schistoso...


    pub_type: 杂志文章


    authors: Elias D,Akuffo H,Pawlowski A,Haile M,Schön T,Britton S

    更新日期:2005-02-03 00:00:00

  • Changes in prevalence of influenza vaccination and strength of association of factors predicting influenza vaccination over time--results of two population-based surveys.

    abstract::Two cross-sectional population-based telephone surveys interviewed 877 and 1,103 respondents aged >or=65. When compared to the first survey, respondents of the second survey were more likely to have heard of influenza vaccination (IV) (adjusted OR=4.09), to have received IV (adjusted OR=2.04) or to have done so in the...


    pub_type: 杂志文章


    authors: Lau JT,Kim JH,Choi KC,Tsui HY,Yang X

    更新日期:2007-11-28 00:00:00

  • Improving the stability of recombinant anthrax protective antigen vaccine.

    abstract::Development of recombinant protective antigen (rPA)-based anthrax vaccines has been hindered by a lack of stability of the vaccines associated with spontaneous deamidation of asparagine (Asn) residues of the rPA antigen during storage. In this study, we explored the role that two deamidation-prone Asn residues located...


    pub_type: 杂志文章


    authors: Verma A,Burns DL

    更新日期:2018-10-15 00:00:00

  • Development of a highly immunogenic recombinant candidate vaccine against human chorionic gonadotropin.

    abstract::Human chorionic gonadotropin (hCG) is synthesized soon after fertilization and is essential for embryonic implantation. A vaccine targeting hCG would be an ideal choice for immuno-contraception; an anti-hCG vaccine developed by Talwar et al., has previously undergone Phase II efficacy trials, providing proof of princi...


    pub_type: 杂志文章


    authors: Purswani S,Talwar GP

    更新日期:2011-03-09 00:00:00

  • A global perspective of vaccination of healthcare personnel against measles: systematic review.

    abstract::Measles transmission has been well documented in healthcare facilities. Healthcare personnel who are unvaccinated and who lack other evidence of measles immunity put themselves and their patients at risk for measles. We conducted a systematic literature review of measles vaccination policies and their implementation i...


    pub_type: 杂志文章,评审


    authors: Fiebelkorn AP,Seward JF,Orenstein WA

    更新日期:2014-08-27 00:00:00

  • Leprosy vaccine: influence of dissolved oxygen levels on growth of a candidate strain (Mycobacterium w), and storage stability of the vaccine.

    abstract::The growth of Mycobacterium w, a candidate strain for leprosy vaccine in submerged culture, was inhibited by the presence of over 40% oxygen saturation in the medium. Intracellular levels of superoxide dismutase and catalase were very low in the beginning. However, under controlled oxygenation, these levels increased ...


    pub_type: 杂志文章


    authors: Mukhopadhyay A,Panda AK,Pandey AK

    更新日期:1998-08-01 00:00:00

  • Hepatitis B virus-like particles expressing Plasmodium falciparum epitopes induce complement-fixing antibodies against the circumsporozoite protein.

    abstract::The repetitive structure of compact virus-like particles (VLPs) provides high density displays of antigenic sequences, which trigger key parts of the immune system. The hepatitis B virus (HBV) and human papilloma virus (HPV) vaccines exploit the assembly competence of structural proteins, which are the effective immun...


    pub_type: 杂志文章


    authors: Kingston NJ,Kurtovic L,Walsh R,Joe C,Lovrecz G,Locarnini S,Beeson JG,Netter HJ

    更新日期:2019-03-14 00:00:00

  • Identifying barriers and drivers to vaccination: A qualitative interview study with health workers in the Federation of Bosnia and Herzegovina.

    abstract:BACKGROUND:Vaccination coverage in Bosnia and Herzegovina has been declining over recent years. A World Health Organization Tailoring Immunization Programmes (TIP) project is underway to gain insights into the underlying reasons for this, to develop tailored interventions. As part of TIP, this study aimed to investigat...


    pub_type: 杂志文章


    authors: Musa S,Skrijelj V,Kulo A,Habersaat KB,Smjecanin M,Primorac E,Becirovic D,Jackson C

    更新日期:2020-02-18 00:00:00

  • Epidemiology of primary varicella hospitalizations in Spain.

    abstract::An approach to the burden of varicella can be obtained from information on the hospitalizations. Data were obtained from the national surveillance system for hospital data. All hospital discharges for varicella were analyzed for the 1995-1998 period. A total of 3632 primary varicella-related discharges were identified...


    pub_type: 杂志文章


    authors: Gil A,Oyagüez I,Carrasco P,González A

    更新日期:2001-11-12 00:00:00

  • Humoral immunity 5 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine.

    abstract::Persistence of antibodies following a single dose of Tdap vaccine (tetanus, diphtheria, and five-component acellular pertussis vaccine for use in individuals past childhood) was evaluated in a follow-up of adolescents (N=324) and adults (N=644) who had received Tdap in earlier clinical trials. Outcome measures were se...


    pub_type: 杂志文章


    authors: Barreto L,Guasparini R,Meekison W,Noya F,Young L,Mills E

    更新日期:2007-11-23 00:00:00

  • Recombinant H7 hemagglutinin forms subviral particles that protect mice and ferrets from challenge with H7N9 influenza virus.

    abstract::A novel avian-origin influenza A H7N9 virus emerged in China in 2013 and continues to cause sporadic human infections with mortality rates approaching 35%. Currently there are no approved human vaccines for H7N9 virus. Recombinant approaches including hemagglutinin (HA) and virus-like particles (VLPs) have resulted in...


    pub_type: 杂志文章


    authors: Pushko P,Pujanauski LM,Sun X,Pearce M,Hidajat R,Kort T,Schwartzman LM,Tretyakova I,Chunqing L,Taubenberger JK,Tumpey TM

    更新日期:2015-09-11 00:00:00

  • Enhanced protection against tuberculosis by vaccination with recombinant BCG over-expressing HspX protein.

    abstract::Immunization with Mycobacterium bovis Bacille Calmette-Guerin (BCG) did not induce adequate Th1 responses to the latency antigen, HspX of M. tuberculosis. To increase the immunogenicity and protective efficacy of BCG, a recombinant BCG strain over-expressing antigen HspX (rBCG::X) was constructed. The recombinant stra...


    pub_type: 杂志文章


    authors: Shi C,Chen L,Chen Z,Zhang Y,Zhou Z,Lu J,Fu R,Wang C,Fang Z,Fan X

    更新日期:2010-07-19 00:00:00

  • Influenza and pneumococcal vaccination and risk of stroke or transient ischaemic attack-matched case control study.

    abstract:BACKGROUND:Evidence that respiratory infections trigger stroke suggests that influenza or pneumococcal vaccination might prevent stroke. We aimed to investigate whether influenza or pneumococcal vaccination or both together were associated with reduced risk of stroke or transient ischaemic attack (TIA). METHODS:We use...


    pub_type: 杂志文章


    authors: Siriwardena AN,Asghar Z,Coupland CC

    更新日期:2014-03-10 00:00:00

  • No association between HPV vaccination and infertility in U.S. females 18-33 years old.

    abstract:BACKGROUND:Human papillomavirus (HPV) vaccines have been recommended as primary prevention of HPV-related cancers for over 10 years in the United States, and evidence reveals decreased incidence of HPV infections following vaccination. However, concerns have been raised that HPV vaccines could decrease fertility. This ...


    pub_type: 杂志文章


    authors: Schmuhl NB,Mooney KE,Zhang X,Cooney LG,Conway JH,LoConte NK

    更新日期:2020-05-19 00:00:00

  • Poliovirus replicons encoding the B subunit of Helicobacter pylori urease elicit a Th1 associated immune response.

    abstract::The development of a vaccine for Helicobacter pylori is a key strategy for reducing the worldwide prevalence of H. pylori infection. Although immunization with recombinant B subunit of H. pylori urease (ureB) has yielded promising results, for the most part, these studies relied on the use of strong adjuvant, cholera ...


    pub_type: 杂志文章


    authors: Novak MJ,Smythies LE,McPherson SA,Smith PD,Morrow CD

    更新日期:1999-05-14 00:00:00

  • Cost-effectiveness of the introduction of two-dose bi-valent (Cervarix) and quadrivalent (Gardasil) HPV vaccination for adolescent girls in Bangladesh.

    abstract:BACKGROUND:Cervical cancer is one of the most prevalent cancers in women caused by the human papillomavirus (HPV) that leads to a substantial disease burden for health systems. Prevention through vaccination can significantly reduce the prevalence of cervical cancer. The objective of this study is to evaluate the poten...


    pub_type: 杂志文章


    authors: Mahumud RA,Gow J,Alam K,Keramat SA,Hossain MG,Sultana M,Sarker AR,Islam SMS

    更新日期:2020-01-10 00:00:00

  • A DNA vaccine encoding VP22 of herpes simplex virus type I (HSV-1) and OprF confers enhanced protection from Pseudomonas aeruginosa in mice.

    abstract::Pseudomonas aeruginosa antimicrobial resistance is a major therapeutic challenge. DNA vaccination is an attractive approach for antigen-specific immunotherapy against P. aeruginosa. We explored the feasibility of employing Herpes simplex virus type 1 tegument protein, VP22, as a molecular tool to enhance the immunogen...


    pub_type: 杂志文章


    authors: Yu X,Wang Y,Xia Y,Zhang L,Yang Q,Lei J

    更新日期:2016-08-17 00:00:00

  • Association of HLA class II genes with clinical hyporesponsiveness to trivalent inactivated influenza vaccine in children.

    abstract:BACKGROUND:The primary prevention measure for influenza infection has been the use of influenza vaccines. However, even when the vaccine and circulating strains are well-matched, some healthy children do not respond to the vaccine, likely due to a genetic basis for immune hyporesponsiveness. The primary objective of th...


    pub_type: 杂志文章


    authors: Narwaney KJ,Glanz JM,Norris JM,Fingerlin TE,Hokanson JE,Rewers M,Hambidge SJ

    更新日期:2013-02-04 00:00:00

  • Use of near-real-time medical claims data to generate timely vaccine coverage estimates in the US: the dynamics of PCV13 vaccine uptake.

    abstract:BACKGROUND:Vaccine coverage estimates lag by years in the US. Commercially available medical claims databases contain timely records of childhood vaccinations given in physician offices. We used such data to track the replacement of the 7-valent pneumococcal conjugate vaccine (PCV7) by PCV13, a new vaccine active again...


    pub_type: 杂志文章


    authors: Schuck-Paim C,Taylor R,Lindley D,Klugman KP,Simonsen L

    更新日期:2013-12-05 00:00:00

  • Development and evaluation of live attenuated Salmonella vaccines in newly hatched duckings.

    abstract::Domestic ducks remain a major source of zoonotic Salmonella enterica infections for man worldwide and approaches to protection should include vaccine-mediated immunity. With this in mind we developed several genetically defined mutants in a virulent duck Salmonella typhimurium isolate TT-1. From initial tests for viru...


    pub_type: 杂志文章


    authors: Tang T,Gao Q,Barrow P,Wang M,Cheng A,Jia R,Zhu D,Chen S,Liu M,Sun K,Yang Q,Chen X

    更新日期:2015-10-13 00:00:00

  • The form of NY-ESO-1 antigen has an impact on the clinical efficacy of anti-tumor vaccination.

    abstract::Anti-tumor vaccination is being evaluated as a prophylactic and therapeutic strategy against cancer growth, dissemination (spreading) or recurrence. Although a large number of studies investigate in detail the identity of antigens to be used for efficacious immune intervention, there have been few studies investigatin...


    pub_type: 杂志文章


    authors: Parvanova I,Rettig L,Knuth A,Pascolo S

    更新日期:2011-05-17 00:00:00

  • Influenza vaccination coverage among adults with diabetes, United States, 2007-08 through 2017-18 seasons.

    abstract:BACKGROUND:Diabetes is associated with higher risk of hospitalization, morbidity, and mortality from influenza. We assessed influenza vaccination coverage among adults aged ≥ 18 years with diabetes during the 2007-08 through 2017-18 influenza seasons and identified factors independently associated with vaccination duri...


    pub_type: 杂志文章


    authors: Hung MC,Lu PJ,Srivastav A,Cheng YJ,Williams WW

    更新日期:2020-09-29 00:00:00

  • Knowledge, attitude and awareness among healthcare professionals about influenza vaccination in Peshawar, Pakistan.

    abstract::A cross-sectional study was carried out among HCPs in Northwest General Hospital & Research Centre, Hayatabad Peshawar, Pakistan. The purpose of this study was to investigate knowledge, awareness and attitude of HCPs towards influenza vaccination. A total of N=170 questionnaires were distributed among the staff. There...


    pub_type: 杂志文章


    authors: Khan TM,Khan AU,Ali I,Wu DB

    更新日期:2016-03-08 00:00:00

  • Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens.

    abstract::In this study, we compare four different adjuvants, LT(R192G), CpG ODN, MPL((R))TDM, and alum, for their ability to affect the magnitude, distribution, and duration of antibody responses against F1-V, the lead-candidate antigen for the next generation vaccine against plague, in a murine model. In addition, three diffe...


    pub_type: 杂志文章


    authors: Uddowla S,Freytag LC,Clements JD

    更新日期:2007-11-19 00:00:00

  • Comparative safety study of three inactivated BTV-8 vaccines in sheep and cattle under field conditions.

    abstract::After massive epidemics of bluetongue disease in 2006 and 2007, Germany has started a compulsory vaccination program against bluetongue virus serotype 8 (BTV-8). Since the available vaccines had not yet been registered and only limited data were available on their performance, a safety study was conducted with three d...


    pub_type: 杂志文章


    authors: Gethmann J,Hüttner K,Heyne H,Probst C,Ziller M,Beer M,Hoffmann B,Mettenleiter TC,Conraths FJ

    更新日期:2009-06-24 00:00:00

  • Perspectives on the control of hepatitis A by vaccination.

    abstract::The availability of an inactivated hepatitis A virus (HAV) vaccine, and the development of live attenuated virus vaccines against hepatitis represent great advances in the effort to control an important cause of viral hepatitis. There are a number of ways hepatitis A vaccines could be used, depending on the epidemiolo...


    pub_type: 杂志文章,评审


    authors: Kane MA

    更新日期:1992-01-01 00:00:00

  • Carrier-dependent specificity of antibodies to a conserved peptide determinant of gp120.

    abstract::Amino acid residues 421-436 constitute a comparatively conserved determinant of gp120 that participates in the binding of host cell CD4 receptors by HIV-1. We compared the immunogenicity of synthetic Cys-gp120 (421-436) conjugated to KLH via the N terminal Cys residue (KLH-I) and gp120 (421-436) extended at its N term...


    pub_type: 杂志文章


    authors: Karle S,Nishiyama Y,Taguchi H,Zhou YX,Luo J,Planque S,Hanson C,Paul S

    更新日期:2003-03-07 00:00:00