当前位置： SCI文献检索 > VACCINE期刊下所有文献 > The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B--a prerequisite for clinical development.

The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B--a prerequisite for clinical development.

Abstract：

:We have recently shown that immunization against the extra domain-B (ED-B) of fibronectin, using Freund's adjuvant, reduces tumor growth in mice by 70%. In the present study we compare the immune response generated against ED-B using the non-toxic and biodegradable adjuvant Montanide ISA 720/CpG with the response elicited by Freund's adjuvant. Montanide ISA 720/CpG induced anti-ED-B antibodies with higher avidity and less variable levels between individuals than Freund's. Moreover, the duration of the immune response was longer and the generation of anti-ED-B antibodies in naïve mice was faster, when Montanide ISA 720/CpG was used. We conclude that it is possible to replace the mineral oil based adjuvant Freund's with an adjuvant acceptable for human use, which is a prerequisite for transfer of the ED-B vaccine to the clinic.

journal_name

Vaccine

journal_title

Vaccine

authors

Huijbers EJ,Femel J,Andersson K,Björkelund H,Hellman L,Olsson AK

doi

10.1016/j.vaccine.2011.11.010

subject

Has Abstract

pub_date

2012-01-05 00:00:00

pages

225-30

issue

2

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)01777-4

journal_volume

30

pub_type

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