Comparative biological activities of whole cell pertussis vaccine and a new acellular preparation.

abstract：:Mucin1 (MUC1) is expressed ubiquitously on breast cancer cells and is a potential target for the generation of cytotoxic T cells for vaccination against breast cancer. Thus far studies of the immunogenicity of MUC1 have used peptides from the variable number of tandem repeat (VNTR); mice so immunised can generate stro...

journal_title：Vaccine

authors： Pietersz GA,Li W,Osinski C,Apostolopoulos V,McKenzie IF

更新日期：2000-04-03 00:00:00

abstract：:In Italy systematic mandatory tetanus immunization of children started in 1968. In a national sample of 241 young males born after 1968 the prevalence of non-immune subjects was 11.2% (5.5% in the North-Centre, 15.9% in the South-Islands; p < 0.02). Comparing these data with the corresponding figure obtained in a prev...

journal_title：Vaccine

authors： D'Amelio R,Stroffolini T,Wirz M,Biselli R,Matricardi PM,Gentili G,Collotti C,Pasquini P

更新日期：1993-01-01 00:00:00

abstract：:We report the use of recombinant scorpion toxins in the form of fusion proteins as antigens for immunisation in rabbits and mice: the aim was to produce in these animal models protective antisera against the most lethal alpha-type toxins in the venom from the North African scorpion Androctonus australis. The cDNAs enc...

journal_title：Vaccine

authors： Legros C,Kaabi H,El Ayeb M,Céard B,Vacher H,Bougis PE,Martin-Eauclaire MF

更新日期：2001-12-12 00:00:00

abstract：:An immuno-informatics study was conducted to determine possible pre-existing T cellular immunity to the recently emerged swine-origin triple reassortant H3N2 variant (S-OtrH3N2v-2011) which acquired the matrix gene of influenza A (H1N1)pdm09. Given the genetic origin of S-OtrH3N2v-2011, our study focused on the hemagg...

journal_title：Vaccine

authors： Duvvuri VR,Marchand-Austin A,Eshaghi A,Patel SN,Low DE,Gubbay JB

更新日期：2012-09-14 00:00:00

abstract：BACKGROUND:After the H1N1 swine flu vaccination campaign an increased number of narcolepsy cases in children and adolescents was observed in Scandinavian and later in further European countries that correlated with the vaccination by an AS03-adjuvanted influenza vaccine (Pandemrix). Narcolepsy is a chronic sleep disord...

journal_title：Vaccine

authors： Masoudi S,Ploen D,Kunz K,Hildt E

更新日期：2014-05-23 00:00:00

abstract：:This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one of the three dose groups (25 mcg, 25 mcg with aluminum hydroxide adju...

journal_title：Vaccine

authors： Keiser PB,Gibbs BT,Coster TS,Moran EE,Stoddard MB,Labrie JE 3rd,Schmiel DH,Pinto V,Chen P,Zollinger WD

更新日期：2010-10-08 00:00:00

abstract：:The vaccination program in Zambia includes one dose of measles vaccine at 9 months of age. The objective of this study was to compare the cost-effectiveness of the current one-dose measles vaccination program with an immunization schedule in which a second dose is provided either through routine health services or thr...

journal_title：Vaccine

authors： Dayan GH,Cairns L,Sangrujee N,Mtonga A,Nguyen V,Strebel P

更新日期：2004-01-02 00:00:00

abstract：:ChimeriVax is a live, attenuated recombinant virus constructed from yellow fever (YF) 17D in which the envelope protein genes of YF 17D are replaced with the corresponding genes of another flavivirus. A ChimeriVax vaccine was developed against Japanese encephalitis (JE). A randomized, double-blind, outpatient study wa...

journal_title：Vaccine

authors： Monath TP,McCarthy K,Bedford P,Johnson CT,Nichols R,Yoksan S,Marchesani R,Knauber M,Wells KH,Arroyo J,Guirakhoo F

更新日期：2002-01-15 00:00:00

abstract：:Vaccination is considered the most cost-effective approach to preventing infectious diseases, yet better formulations and delivery methods for efficient distribution and administration of vaccines are needed, especially for low-resource settings. A fast-dissolving tablet (FDT) that could be packaged in a compact stack...

journal_title：Vaccine

authors： Lal M,Priddy S,Bourgeois L,Walker R,Pebley W,Brown J,Desai J,Darsley MJ,Kristensen D,Chen D

更新日期：2013-10-01 00:00:00

abstract：:Influenza virus hemagglutinin (HA) and neuraminidase (NA) proteins elicit protective antibody responses and therefore, are used as targets for vaccination, especially the HA protein. However, these proteins are subject to antigenic drift, decreasing vaccine efficacy, and few to no studies have analyzed antigenic varia...

journal_title：Vaccine

authors： DeDiego ML,Chiem K,Topham DJ

更新日期：2018-10-15 00:00:00

abstract：:Immunostimulating complexes (ISCOMs) are subunit vaccines that are particularly effective in producing immunity against systemic viral infections, but their effectiveness against mucosal infections has received little attention. To study their ability to produce mucosal immune responses in the female reproductive trac...

journal_title：Vaccine

authors： Thapar MA,Parr EL,Bozzola JJ,Parr MB

更新日期：1991-02-01 00:00:00

abstract：:Vaccine effects of in vivo gene-vaccinated skin graft were evaluated against Toxoplasma gondii (T. gondii) infection. By using a gene gun, cDNA coding T. gondii SAG1 molecule was intracutaneously vaccinated into C57BL/6 (B6; a susceptible strain), BALB/c (a resistant strain) and (C57BL/6 x BALB/c) F1 (CBF1) mice, and ...

journal_title：Vaccine

authors： Saito S,Aosai F,Rikihisa N,Mun HS,Norose K,Chen M,Kuroki T,Asano T,Ochiai T,Hata H,Ichinose M,Yano A

更新日期：2001-02-28 00:00:00

abstract：:The nontoxic N-terminal fragment of Bacillus anthracis edema factor (EF) was evaluated as a candidate antigen in an anthrax vaccine using a replication-incompetent adenoviral vector. An E1/E3 deleted adenovirus (Ad/EFn) encoding the N-terminal region 1-254 amino acids of the edema factor (EFn) was constructed using th...

journal_title：Vaccine

authors： Zeng M,Xu Q,Hesek ED,Pichichero ME

更新日期：2006-01-30 00:00:00

abstract：:Availability of new rotavirus vaccines highlights the need to maintain and enhance rotavirus strain surveillance. We collected stool samples from children with gastroenteritis admitted to eight hospitals in South Korea from April 2005 to March 2007. Of the 6057 samples collected, 1337 (22%) were positive for rotavirus...

journal_title：Vaccine

authors： Lee SY,Hong SK,Lee SG,Suh CI,Park SW,Lee JH,Kim JH,Kim DS,Kim HM,Jang YT,Ma SH,Kim SY,Sohn YS,Kang JH,Paik SY

更新日期：2009-11-20 00:00:00

abstract：:The current human whole-cell vaccine is ineffective against pneumonic plague caused by typical F1 capsule positive (F1+) strains of Yersinia pestis. The authors found this vaccine to also be ineffective against F1-negative (F1-) Y. pestis strains, which have been isolated from a human case and from rodents. For these ...

journal_title：Vaccine

authors： Heath DG,Anderson GW Jr,Mauro JM,Welkos SL,Andrews GP,Adamovicz J,Friedlander AM

更新日期：1998-07-01 00:00:00

abstract：:In a large series of post-vaccination samples we compared the result of three commercially available anti-HBs assays (AxSYM, Architect and Access) on the quantitation of anti-HBs after immunisation with Engerix-B (HBsAg/ad) and GenHevacB (HBsAg/ay) vaccine. Two of the assays (AxSYM, Architect: Abbott Laboratories) gav...

journal_title：Vaccine

authors： Heijtink RA,Schneeberger PM,Postma B,Crombach W

更新日期：2002-07-26 00:00:00

abstract：BACKGROUND:The safety and tolerability of Flublok(®), a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA(®) in a randomized, blinded clinical trial in adults ≥ 50 years of age with attention to hypersensitivity reactions. METHODS:This blinded, randomized trial of healthy adults ≥ ...

journal_title：Vaccine

authors： Izikson R,Leffell DJ,Bock SA,Patriarca PA,Post P,Dunkle LM,Cox MM

更新日期：2015-11-27 00:00:00

abstract：:The aim of this study was to assess the uptake of varicella vaccine in South Australian children under circumstances where varicella immunisation is recommended, but is not funded by Government. The study examined the main reasons that determined a parent's decision whether or not to have their child immunised with va...

journal_title：Vaccine

authors： Marshall H,Ryan P,Roberton D

更新日期：2005-11-16 00:00:00

abstract：:Because of delays in the manufacturing of the 2000-2001, trivalent inactivated influenza vaccine in the US, there were concerns that there might be shortages of vaccine supply in the US. Therefore, we conducted a prospective, randomized, open-label, multicenter trial at six academic medical centers in the US, to evalu...

journal_title：Vaccine

authors： Treanor J,Keitel W,Belshe R,Campbell J,Schiff G,Zangwill K,Wolff M,Klimov A,Levandowski R,Lambert L

更新日期：2002-01-15 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects cloven-hoofed animal species. The FMDV capsid is highly acid labile and viral particles lose their immunogenicity when they disassemble at mildly acidic pHs. The viral capsid of FMDV serotype O is more sensitive th...

journal_title：Vaccine

authors： Xie Y,Li H,Qi X,Ma Y,Yang B,Zhang S,Chang H,Yin X,Li Z

更新日期：2019-03-28 00:00:00

abstract：:Alternative DNA vaccine constructs such as fully synthetic linear expressing cassettes (LECs) offer the advantage of accelerated manufacturing techniques as well as the lack of both antibiotic resistance genes and bacterial contaminants. The speed of manufacture makes LEC technology a possible future vaccination strat...

journal_title：Vaccine

authors： Shen X,Söderholm J,Lin F,Kobinger G,Bello A,Gregg DA,Broderick KE,Sardesai NY

更新日期：2012-11-06 00:00:00

abstract：BACKGROUND:BCG vaccine, introduced almost 100years ago, is the only option to prevent TB disease. It effectively protects newborns from meningeal TB but fails to prevent adult pulmonary TB. TB kills 1.3million people annually in areas where BCG vaccination is widely practiced. Thus, more effective TB vaccines are urgen...

journal_title：Vaccine

authors： Lau A,Singh V,Soualhine H,Hmama Z

更新日期：2017-04-11 00:00:00

abstract：:The recent resurgence of pertussis in England and Wales has been marked by infant deaths and rising cases in teens and adults. To understand which age cohorts are most responsible for these trends, we employed three separate statistical methods to analyze high-resolution pertussis reports from 1982 to 2012. The fine-g...

journal_title：Vaccine

authors： Bento AI,Riolo MA,Choi YH,King AA,Rohani P

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Due in part to declining vaccination rates, in 2018 over 20 states reported at least one case of measles, and over 40,000 cases were confirmed in Europe. Anti-vaccine posts on social media may be facilitating anti-vaccination behaviour. This study aimed to systematically characterize (1) individuals known to...

journal_title：Vaccine

authors： Hoffman BL,Felter EM,Chu KH,Shensa A,Hermann C,Wolynn T,Williams D,Primack BA

更新日期：2019-04-10 00:00:00

abstract：:Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in about 150,000 individuals in Eurasia, and several hundred cases of hantavirus pulmonary syndrome (HPS) on the American continent annually. There is consequently a need for rapid diagnostics and effective prevention of hantaviral infections. In this stu...

journal_title：Vaccine

authors： Lindkvist M,Lahti K,Lilliehöök B,Holmström A,Ahlm C,Bucht G

更新日期：2007-02-19 00:00:00

abstract：:We assessed whether measles virus-specific antibody levels in the Dutch population as estimated by an enzyme-linked immunosorbent assay (ELISA) were comparable with estimates by virus neutralisation assay (NT), prompted by a relatively low ELISA seroprevalence in the 10-21-year-old group. We tested 791 sera from indiv...

journal_title：Vaccine

authors： van den Hof S,van Gageldonk-Lafeber AB,van Binnendijk RS,van Gageldonk PG,Berbers GA

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:The Expanded Programme on Immunization (EPI), launched in 1974, has developed and implemented a range of strategies and practices over the last three decades to ensure that children and adults receive the vaccines they need to help protect them against vaccine-preventable diseases. Many of these strategies h...

journal_title：Vaccine

authors： Clements CJ,Watkins M,de Quadros C,Biellik R,Hadler J,McFarland D,Steinglass R,Luman E,Hennessey K,Dietz V

更新日期：2011-11-03 00:00:00

abstract：:Annual vaccination rates among French health care workers (HCWs) are in decline even in Emergency Services to which patients at highest risk of influenza complications are admitted, and in which HCWs have the greatest risk of exposure to influenza from patients. We aimed here to identify knowledge and attitudes toward...

journal_title：Vaccine

authors： Hulo S,Nuvoli A,Sobaszek A,Salembier-Trichard A

更新日期：2017-01-05 00:00:00

abstract：:The antibody response elicited after immunization with vaccinia virus (VacV) is known to be sufficient to confer host protection against VacV or smallpox. In humans it has been shown that such anti-VacV antibody production can be sustained for decades. Nevertheless, little is known about the kinetics and the role in p...

journal_title：Vaccine

authors： Moyron-Quiroz JE,McCausland MM,Kageyama R,Sette A,Crotty S

更新日期：2009-12-10 00:00:00

abstract：:Viral hemorrhagic septicemia (VHS) in olive flounder (Paralichthys olivaceus) remains an unsolved health problem in Korean aquaculture. Vaccination plays a significant role in modern aquaculture, and the duration of protection provided is of vital importance. Here, we have demonstrated the efficacy, duration of protec...

journal_title：Vaccine

authors： Vinay TN,Kim YJ,Jung MH,Kim WS,Kim DH,Jung SJ

更新日期：2013-09-23 00:00:00