当前位置： SCI文献检索 > VACCINE期刊下所有文献 > A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA.

A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA.

Abstract：

:This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one of the three dose groups (25 mcg, 25 mcg with aluminum hydroxide adjuvant, and 50 mcg) to receive three intramuscular injections at 0, 6 and 24 weeks. Specific local and systemic adverse events (AEs) were solicited by diary and at visits on days 1, 2, 7 and 14 after each vaccination and at the end of the study at 30 weeks. Blood chemistries, complete blood count, and coagulation studies were measured on each vaccination day and again two days later. Blood for antibody measurements and bactericidal assays were drawn 0, 14, and 42 days after each vaccination. The proportion of volunteers who developed a fourfold or greater increase in serum bactericidal activity (SBA) to the wild-type parent of the vaccine strain with high opcA expression at 6 weeks after the third dose was 12/26 (0.46, 95% confidence interval 0.27-0.65). Antibody levels to OpcA were significantly higher in vaccine responders than in non-responders (p=0.008), and there was a trend for higher antibody levels to the lipooligosaccharide (LOS) (p=0.059). Bactericidal depletion assays on sera from volunteers with high-titer responses also indicate a major contribution of anti-OpcA and anti-LOS antibodies to the bactericidal response.These results suggest that genetically modified NOMV vaccines can induce protection against group B meningococcus.

journal_name

Vaccine

journal_title

Vaccine

authors

Keiser PB,Gibbs BT,Coster TS,Moran EE,Stoddard MB,Labrie JE 3rd,Schmiel DH,Pinto V,Chen P,Zollinger WD

doi

10.1016/j.vaccine.2010.08.048

subject

Has Abstract

pub_date

2010-10-08 00:00:00

pages

6970-6

issue

43

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)01193-X

journal_volume

28

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Poliovirus replicons encoding the B subunit of Helicobacter pylori urease elicit a Th1 associated immune response.

    abstract：:The development of a vaccine for Helicobacter pylori is a key strategy for reducing the worldwide prevalence of H. pylori infection. Although immunization with recombinant B subunit of H. pylori urease (ureB) has yielded promising results, for the most part, these studies relied on the use of strong adjuvant, cholera ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00035-3

    authors： Novak MJ,Smythies LE,McPherson SA,Smith PD,Morrow CD

    更新日期：1999-05-14 00:00:00

  • Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence.

    abstract：BACKGROUND:Vaccinations have been suggested to be associated with increased risk of allergic diseases. Tetanus vaccination is one of the most frequently administered vaccines as a part of wound management and was also found to be associated with increased serum IgE levels. We hypothesized that the vaccination modifies ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.10.068

    authors： Janjanam VD,Mukherjee N,Lockett GA,Rezwan FI,Kurukulaaratchy R,Mitchell F,Zhang H,Arshad H,Holloway JW,Karmaus W

    更新日期：2016-12-12 00:00:00

  • Low uptake of influenza vaccine among university students: evaluating predictors beyond cost and safety concerns.

    abstract：INTRODUCTION:Annual influenza vaccine coverage for young adults (including college students) remains low, despite a 2011 US recommendation for annual immunization of all people 6 months and older. College students are at high risk for influenza morbidity given close living and social spaces and extended travel during s...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.02.033

    authors： Bednarczyk RA,Chu SL,Sickler H,Shaw J,Nadeau JA,McNutt LA

    更新日期：2015-03-30 00:00:00

  • A local reaction at or near injection site: case definition and guidelines for collection, analysis, and presentation of immunization safety data.

    abstract：:The need for developing a case definition and guidelines for a local reaction at or near the injection site, methods for the development of the case definition and guidelines as an adverse event following immunization as well as the rationale for selected decisions about the case definition for a local reaction at or ...

    journal_title：Vaccine

    pub_type： 指南,杂志文章

    doi：10.1016/j.vaccine.2008.10.006

    authors： Gidudu J,Kohl KS,Halperin S,Hammer SJ,Heath PT,Hennig R,Hoet B,Rothstein E,Schuind A,Varricchio F,Walop W,Brighton Collaboration Local Reactions Working Group for a Local Reaction at or near Injection Site.

    更新日期：2008-12-09 00:00:00

  • Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease.

    abstract：:Serotype-specific protective immunity in pediatric patients with invasive pneumococcal disease (IPD) has not been fully investigated. To determine the protective immunity to the infecting serotype, the serotype-specific immunoglobulin G (IgG) levels and opsonization indices (OIs) were examined in 24 Japanese pediatric...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.11.010

    authors： Oishi T,Ishiwada N,Matsubara K,Nishi J,Chang B,Tamura K,Akeda Y,Ihara T,Nahm MH,Oishi K,Japanese IPD Study Group.

    更新日期：2013-01-21 00:00:00

  • Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response.

    abstract：:To determine the potential for biodegradable alginate microspheres to be used as a delivery vehicle for DNA based vaccines, we constructed a plasmid, pMNe-gal-SV40, containing the bacterial beta-galactosidase (LacZ) gene under the control of the murine cytomegalovirus (MCMV) immediate-early promoter and the simian vir...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00170-5

    authors： Mittal SK,Aggarwal N,Sailaja G,van Olphen A,HogenEsch H,North A,Hays J,Moffatt S

    更新日期：2000-09-15 00:00:00

  • Mumps disease in Beijing in the era of two-dose vaccination policy, 2005-2016.

    abstract：BACKGROUND:Since the introduction of mumps-containing vaccines (MuCV) in 1995 in Beijing, two-dose MuCV vaccination policy has been used, with the 1st and 2nd doses given at 18 months and 6 years of age, respectively. METHODS:Mumps epidemiology during 2005-2016 was described using surveillance data. Vaccine effectiven...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.03.074

    authors： Ma R,Lu L,Zhou T,Pan J,Chen M,Pang X

    更新日期：2018-05-03 00:00:00

  • Pediatric immunization-related safety incidents in primary care: A mixed methods analysis of a national database.

    abstract：BACKGROUND:Children are scheduled to receive 18-20 immunizations before their 18th birthday in England and Wales; this approximates to 13 million vaccines administered per annum. Each immunization represents a potential opportunity for immunization-related error and effective immunization is imperative to maintain the ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.06.068

    authors： Rees P,Edwards A,Powell C,Evans HP,Carter B,Hibbert P,Makeham M,Sheikh A,Donaldson L,Carson-Stevens A

    更新日期：2015-07-31 00:00:00

  • Intramuscular delivery of a cholera DNA vaccine primes both systemic and mucosal protective antibody responses against cholera.

    abstract：:Cholera is a potentially lethal diarrhea disease caused by the gram-negative bacterium Vibrio cholerae. The need for an effective cholera vaccine is clearly indicated but the challenges of eliciting both systemic and mucosal immune responses remains a significant challenge. In the current report, we discovered that a ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.04.008

    authors： Xu G,Wang S,Zhuang L,Hackett A,Gu L,Zhang L,Zhang C,Wang H,Huang Z,Lu S

    更新日期：2009-06-12 00:00:00

  • Liposomes containing monophosphoryl lipid A and QS-21 serve as an effective adjuvant for soluble circumsporozoite protein malaria vaccine FMP013.

    abstract：:Malaria caused by Plasmodium falciparum continues to threaten millions of people living in the tropical parts of the world. A vaccine that confers sterile and life-long protection remains elusive despite more than 30years of effort and resources invested in solving this problem. Antibodies to a malaria vaccine candida...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.05.070

    authors： Genito CJ,Beck Z,Phares TW,Kalle F,Limbach KJ,Stefaniak ME,Patterson NB,Bergmann-Leitner ES,Waters NC,Matyas GR,Alving CR,Dutta S

    更新日期：2017-07-05 00:00:00

  • Cloning and assessment of tumorigenicity and oncogenicity of a Madin-Darby canine kidney (MDCK) cell line for influenza vaccine production.

    abstract：:An Madin-Darby canine kidney (MDCK) cell line, 9B9-1E4, was cloned by limit dilution from a heterologous cell population and chosen as a potential production cell substrate for cell culture-based influenza vaccine manufacture. Since MDCK cells are transformed cells of canine origin, extensive characterization, includi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.11.023

    authors： Liu J,Mani S,Schwartz R,Richman L,Tabor DE

    更新日期：2010-02-03 00:00:00

  • Health and economic benefits of single-dose HPV vaccination in a Gavi-eligible country.

    abstract：BACKGROUND:Although guidelines for prophylactic human papillomavirus (HPV) vaccination recommend two doses for girls ages 9-14 years, several studies have demonstrated similar protection with one dose. Our objective was to evaluate the long-term health and economic impacts of routine one-dose HPV vaccination compared t...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.04.061

    authors： Burger EA,Campos NG,Sy S,Regan C,Kim JJ

    更新日期：2018-08-06 00:00:00

  • Arguments and sources on Italian online forums on childhood vaccinations: Results of a content analysis.

    abstract：BACKGROUND:Despite being committed to the immunization agenda set by the WHO, Italy is currently experiencing decreasing vaccination rates and increasing incidence of vaccine-preventable diseases. Our aim is to analyze Italian online debates on pediatric immunizations through a content analytic approach in order to qua...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.11.007

    authors： Fadda M,Allam A,Schulz PJ

    更新日期：2015-12-16 00:00:00

  • Mucosal immunization against hepatitis A: antibody responses are enhanced by co-administration of synthetic oligodeoxynucleotides and a novel cationic lipid.

    abstract：:Hepatitis A caused by hepatitis A virus (HAV) transmitted by the fecal-oral route, results in considerable morbidity and economic loss. Mucosal immunization can be more effective than conventional injection at inducing both local and systemic immunity to HAV. Here we show that co-administration of killed HAV with synt...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.04.015

    authors： Mitchell LA,Joseph A,Kedar E,Barenholz Y,Galun E

    更新日期：2006-06-19 00:00:00

  • Quantification of pertussis toxin, filamentous haemagglutinin, 69 kDa outer membrane protein, agglutinogens 2 and 3 and lipopolysaccharide in the Danish whole-cell pertussis vaccine.

    abstract：:The amounts of pertussis toxin (PT), filamentous haemagglutinin (FHA), 69 kDa outer membrane protein (69 kDa OMP) and agglutinogens (AGG) 2 and 3 in extracts from the Danish whole-cell pertussis vaccine were studied in quantitative capture ELISA. With the exception of PT, the most effective extraction of these antigen...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(93)90193-2

    authors： Ibsen PH,Petersen JW,Heron I

    更新日期：1993-01-01 00:00:00

  • Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections.

    abstract：:A safe and effective pan-filovirus vaccine is highly desirable since the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) cause highly lethal disease typified by unimpeded viral replication and severe hemorrhagic fever. Previously, we showed that expression of the homologous glycoprotein (GP) and matrix protein...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.11.070

    authors： Swenson DL,Warfield KL,Negley DL,Schmaljohn A,Aman MJ,Bavari S

    更新日期：2005-04-27 00:00:00

  • Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage.

    abstract：:The proteolytic enzyme bromelain has been traditionally used to cleave the hemagglutinin (HA) protein at the C-terminus of the HA2 region to release the HA proteins from influenza virions. The bromelain cleaved HA (BHA) has been routinely used as an antigen to generate antiserum that is essential for influenza vaccine...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.11.101

    authors： Wang W,Suguitan AL Jr,Zengel J,Chen Z,Jin H

    更新日期：2012-01-20 00:00:00

  • Romurtide, a synthetic muramyl dipeptide derivative, accelerates peripheral platelet recovery in nonhuman primate chemotherapy model.

    abstract：:We investigated the therapeutic effects of romurtide, a synthetic muramyl dipeptide derivative, on experimental thrombocytopenia induced by carboplatin in cynomolgus monkeys. A prolonged thrombocytopenia due to a severe myelosuppression was induced by carboplatin. Romurtide given subcutaneously elevated significantly ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00064-3

    authors： Namba K,Nitanai H,Otani T,Azuma I

    更新日期：1996-10-01 00:00:00

  • Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD.

    abstract：:A bovine herpesvirus 4 was isolated from the milk cell fraction of a healthy cow and his full genome cloned as a bacterial artificial chromosome. So cloned viral genome was used as a vector platform to deliver in vitro and in vivo an optimized secreted chimeric peptide obtained by the fusion of the bovine viral diarrh...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.09.023

    authors： Donofrio G,Sartori C,Franceschi V,Capocefalo A,Cavirani S,Taddei S,Flammini CF

    更新日期：2008-11-11 00:00:00

  • Healthy individuals' immune response to the Bulgarian Crimean-Congo hemorrhagic fever virus vaccine.

    abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV) poses a great threat to public health due to its high mortality and transmission rate and wide geographical distribution. There is currently no specific antiviral therapy for CCHF. This study provides the first in-depth analysis of the cellular and humoral immune response ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.08.003

    authors： Mousavi-Jazi M,Karlberg H,Papa A,Christova I,Mirazimi A

    更新日期：2012-09-28 00:00:00

  • Impact of heptavalent pneumococcal conjugate vaccine on invasive disease, antimicrobial resistance and colonization in Alaska Natives: progress towards elimination of a health disparity.

    abstract：:We evaluated invasive pneumococcal disease (IPD), antimicrobial resistance and nasopharyngeal colonization before and after introduction of pneumococcal conjugate vaccine (PCV7) in Alaska Natives (AN), a population with high IPD rates. We obtained IPD rates from population-based surveillance. Colonization was determin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.08.100

    authors： Hennessy TW,Singleton RJ,Bulkow LR,Bruden DL,Hurlburt DA,Parks D,Moore M,Parkinson AJ,Schuchat A,Butler JC

    更新日期：2005-12-01 00:00:00

  • Diphtheria antitoxin response to DTP vaccines used in Swedish pertussis vaccine trials, persistence and projection for timing of booster.

    abstract：:Data from two Swedish pertussis vaccine trials with various combination vaccines were used to compare anti-diphtheria antitoxin concentrations over time between different vaccines, vaccine lots and vaccine schedules. The immune responses were measured with a validated ELISA method.Results are given for 1326 children, ...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0264-410x(99)00539-3

    authors： Tiru M,Hallander HO,Gustafsson L,Storsaeter J,Olin P

    更新日期：2000-04-28 00:00:00

  • New Wisdom to Defy an Old Enemy: Summary from a scientific symposium at the 4th Influenza Vaccines for the World (IVW) 2012 Congress, 11 October, Valencia, Spain.

    abstract：:Both seasonal and pandemic influenza cause considerable morbidity and mortality globally. In addition, the ongoing threat of new, unpredictable influenza pandemics from emerging variant strains cannot be underestimated. Recently bioCSL (previously known as CSL Biotherapies) sponsored a symposium 'New Wisdom to Defy an...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.02.033

    authors： Poland GA,Fleming DM,Treanor JJ,Maraskovsky E,Luke TC,Ball EM,Poland CM

    更新日期：2013-04-17 00:00:00

  • Building health workforce capacity for planning and monitoring through the Strengthening Technical Assistance for routine immunization training (START) approach in Uganda.

    abstract：INTRODUCTION:The Global Vaccine Action Plan identifies workforce capacity building as a key strategy to achieve strong immunization programs. The Strengthening Technical Assistance for Routine Immunization Training (START) approach aimed to utilize practical training methods to build capacity of district and health cen...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.04.015

    authors： Ward K,Stewart S,Wardle M,Sodha SV,Tanifum P,Ayebazibwe N,Mayanja R,Luzze H,Ehlman DC,Conklin L,Abbruzzese M,Sandhu HS

    更新日期：2019-05-09 00:00:00

  • Influenza during pregnancy: Incidence, vaccination coverage and attitudes toward vaccination in the French web-based cohort G-GrippeNet.

    abstract：INTRODUCTION:Pregnancy is a risk factor for severe influenza. However, data on influenza incidence during pregnancy are scarce. Likewise, no data are available on influenza vaccine coverage in France since national recommendation in 2012. We aimed to assess these points using a novel nationwide web-based surveillance s...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.03.034

    authors： Loubet P,Guerrisi C,Turbelin C,Blondel B,Launay O,Bardou M,Goffinet F,Colizza V,Hanslik T,Kernéis S,GGNET study group.

    更新日期：2016-04-29 00:00:00

  • Bacillus subtilis spores as adjuvants for DNA vaccines.

    abstract：:Recently, Bacillus subtilis spores were shown to be endowed with strong adjuvant capacity when co-administered with purified antigenic proteins. In the present study we assessed whether spores possess adjuvant properties when combined with DNA vaccines. We showed that B. subtilis spores promoted the activation of dend...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.03.043

    authors： Aps LR,Diniz MO,Porchia BF,Sales NS,Moreno AC,Ferreira LC

    更新日期：2015-05-11 00:00:00

  • An LASV GPC pseudotyped virus based reporter system enables evaluation of vaccines in mice under non-BSL-4 conditions.

    abstract：:Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.07.101

    authors： Li Q,Liu Q,Huang W,Wu J,Nie J,Wang M,Zhao C,Zhang L,Wang Y

    更新日期：2017-09-12 00:00:00

  • Immune effects of the vaccine of live attenuated Aeromonas hydrophila screened by rifampicin on common carp (Cyprinus carpio L).

    abstract：:Aeromonas hydrophila, as a strong Gram-negative bacterium, can infect a wide range of freshwater fish, including common carp Cyprinus carpio, and cause the huge economic loss. To create the effective vaccine is the best way to control the outbreak of the disease caused by A. hydrophila. In this study, a live attenuate...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.04.075

    authors： Jiang X,Zhang C,Zhao Y,Kong X,Pei C,Li L,Nie G,Li X

    更新日期：2016-06-08 00:00:00

  • Transcutaneous immunization with a novel lipid-based adjuvant protects against Chlamydia genital and respiratory infections.

    abstract：:Mucosal adjuvants are important to overcome the state of immune tolerance normally associated with mucosal delivery and to enhance adaptive immunity to often-weakly immunogenic subunit vaccine antigens. Unfortunately, adverse side effects of many experimental adjuvants limit the number of adjuvants approved for vaccin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.08.001

    authors： Hickey DK,Aldwell FE,Beagley KW

    更新日期：2009-10-19 00:00:00

  • In ovo administration of Toll-like receptor ligands encapsulated in PLGA nanoparticles impede tumor development in chickens infected with Marek's disease virus.

    abstract：:One of the economically important diseases in the poultry industry is Marek's disease (MD) which is caused by Marek's disease virus (MDV). The use of current vaccines provides protection against clinical signs of MD in chickens. However, these vaccines do not prevent the transmission of MDV to susceptible hosts, hence...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.05.091

    authors： Bavananthasivam J,Alkie TN,Astill J,Abdul-Careem MF,Wootton SK,Behboudi S,Yitbarek A,Sharif S

    更新日期：2018-06-27 00:00:00