Mucosal immunization against hepatitis A: antibody responses are enhanced by co-administration of synthetic oligodeoxynucleotides and a novel cationic lipid.

Abstract:

:Hepatitis A caused by hepatitis A virus (HAV) transmitted by the fecal-oral route, results in considerable morbidity and economic loss. Mucosal immunization can be more effective than conventional injection at inducing both local and systemic immunity to HAV. Here we show that co-administration of killed HAV with synthetic oligodeoxynucleotides (ODNs) containing CpG sequences, and a novel polycationic sphingolipid (CCS)/cholesterol liposomal delivery system, markedly enhances the HAV-specific antibody response at the intestinal interface, particularly when delivered intrarectally or intranasally, to Balb/c mice at low HAV doses. A mucosally delivered, antigen-sparing HAV vaccine that is easily administered without specialized equipment or personnel, is an attractive alternative for facilitating mass immunization in hepatitis A outbreaks.

journal_name

Vaccine

journal_title

Vaccine

authors

Mitchell LA,Joseph A,Kedar E,Barenholz Y,Galun E

doi

10.1016/j.vaccine.2006.04.015

subject

Has Abstract

pub_date

2006-06-19 00:00:00

pages

5300-10

issue

25

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00445-2

journal_volume

24

pub_type

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