Abstract：
:A bovine herpesvirus 4 was isolated from the milk cell fraction of a healthy cow and his full genome cloned as a bacterial artificial chromosome. So cloned viral genome was used as a vector platform to deliver in vitro and in vivo an optimized secreted chimeric peptide obtained by the fusion of the bovine viral diarrhoea virus glycoprotein E2 ectodomain with the bovine herpesvirus 1 glycoprotein D ectodomain. Recombinant virus infected cells robustly expressed and secreted the chimeric peptide into the culture medium and inoculated animals with the recombinant virus successfully responded toward antigens, gE2 and gD. Thus, this work has implications for the development of safe and effective polyvalent vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Donofrio G,Sartori C,Franceschi V,Capocefalo A,Cavirani S,Taddei S,Flammini CFdoi
10.1016/j.vaccine.2008.09.023subject
Has Abstractpub_date
2008-11-11 00:00:00pages
6031-42issue
48eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)01252-8journal_volume
26pub_type
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