Abstract:
:We evaluated immunologic predictors of response to HBV vaccine administered in the presence or absence of GM-CSF in HIV infected individuals. We measured peripheral blood hematopoietic progenitor, monocyte and myeloid-derived suppressor cell (MDSC) frequencies, and expression of GMCSF receptor on monocytes and MDSCs, at baseline and 4weeks after immunization in relation to antibody response. We observed higher baseline progenitor and lower monocyte frequencies among week 16 antibody responders. Week 4 decline in MDSC frequency was associated with week 16 antibody response, while administration of GM-CSF was associated with preservation of these cells. No significant differences in GM-CSF receptor expression were observed in the presence vs. absence of GM-CSF. These findings are consistent with a positive role of progenitor cells and a potential negative role of monocytes in vaccine response. Additionally, GM-CSF augmented the preservation of peripheral blood MDSC, which may contribute to the lack of improved vaccine responses.
journal_name
Vaccinejournal_title
Vaccineauthors
Anthony DD,Umbleja T,Aberg JA,Kang M,Medvik K,Lederman MM,Peters MG,Koziel MJ,Overton ETdoi
10.1016/j.vaccine.2011.02.092subject
Has Abstractpub_date
2011-04-27 00:00:00pages
3558-63issue
19eissn
0264-410Xissn
1873-2518pii
S0264-410X(11)00340-9journal_volume
29pub_type
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