Abstract:
:Human metapneumovirus (HMPV) is an important cause of acute respiratory tract disease for which the development of vaccine candidates is warranted. We have previously described the generation of an iscom matrix-adjuvanted HMPV fusion protein subunit vaccine (Fsol) and a live-attenuated vaccine (HMPVM11). Here, we evaluate the immunogenicity and efficacy of these vaccines in cynomolgus macaques. Immunization with Fsol induced HMPV F-specific antibody responses, virus neutralizing antibody titers, and cellular immune responses, but the induced humoral immune response waned rapidly over time. HMPVM11 was strongly attenuated and displayed limited immunogenicity, although immunization with this virus primed for a good secondary HMPV-specific lymphoproliferative response after challenge infection. The duration of virus shedding in HMPVM11-immunized animals was reduced compared to sham-immunized animals. Both vaccines induced HMPV-specific immune responses, but the rapid waning of immunity is a challenging obstacle for vaccine development.
journal_name
Vaccinejournal_title
Vaccineauthors
Herfst S,Schrauwen EJ,de Graaf M,van Amerongen G,van den Hoogen BG,de Swart RL,Osterhaus AD,Fouchier RAdoi
10.1016/j.vaccine.2008.05.052subject
Has Abstractpub_date
2008-08-05 00:00:00pages
4224-30issue
33eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)00643-9journal_volume
26pub_type
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