Phase I/II studies to evaluate safety and immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy adults.

abstract：BACKGROUND:Germany introduced routine varicella (V) vaccination in 2004. Due to a slightly increased risk of febrile convulsions after first-dose application of combined measles-mumps-rubella-varicella (MMRV) vaccine separate first-dose vaccinations with MMR and monovalent V vaccine were recommended in September 2011. ...

journal_title：Vaccine

authors： Streng A,Liese JG

更新日期：2014-02-12 00:00:00

abstract：INTRODUCTION:Ghana introduced monovalent rotavirus vaccine in April 2012. We sought to determine the long-term impact of routine rotavirus vaccination on rotavirus gastroenteritis hospitalizations in Ghana during the first 4 years following rotavirus vaccine introduction. METHODS:Active sentinel surveillance for acute...

journal_title：Vaccine

authors： Enweronu-Laryea CC,Armah G,Sagoe KW,Ansong D,Addo-Yobo E,Diamenu SK,Mwenda JM,Parashar UD,Tate JE

更新日期：2018-11-12 00:00:00

abstract：:A newly developed human diploid cell rabies vaccine (Lyssavac-HDC), produced without added serum albumin and with an effort to remove the virus-inactivating beta-propriolactone prior to addition of the gelatin, L-cysteine and potassium phosphate stabilizer, was tested for safety immunogenicity, adverse reactions and e...

journal_title：Vaccine

authors： Wilde H,Glueck R,Khawplod P,Cryz SJ,Tantawichien T,Thipkong P,Chomchey P,Prakongsri S,Benjavongkulchai M,Sumboonanondha A

更新日期：1995-04-01 00:00:00

abstract：:Some technological and immunological problems facing the preparation of subunit viral vaccines are discussed. Solubilization of enveloped virus glycoproteins with various detergents has been studied. It has been demonstrated that a novel non-ionic detergent, MESK, can be used to prepare the glycoproteins of enveloped ...

journal_title：Vaccine

authors： Berezin VE,Zaides VM,Isaeva ES,Artamonov AF,Zhdanov VM

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:Therapeutic vaccination is a novel treatment approach for chronic hepatitis B, but only had limited success so far. We hypothesized that optimized vaccination schemes have increased immunogenicity, and aimed at increasing therapeutic hepatitis B vaccine efficacy. METHODS:Modified Vaccinia virus Ankara (MVA)...

journal_title：Vaccine

authors： Backes S,Jäger C,Dembek CJ,Kosinska AD,Bauer T,Stephan AS,Dišlers A,Mutwiri G,Busch DH,Babiuk LA,Gasteiger G,Protzer U

更新日期：2016-02-10 00:00:00

abstract：:GPI-0100 is a semi-synthetic saponin with modifications designed to augment stability and diminish toxicity. Two batches of GPI-0100 (the second with higher purity) were tested with doses ranging between 100 and 5000 microg in groups of five treated prostate cancer patients who had no evidence of disease except for ri...

journal_title：Vaccine

authors： Slovin SF,Ragupathi G,Fernandez C,Jefferson MP,Diani M,Wilton AS,Powell S,Spassova M,Reis C,Clausen H,Danishefsky S,Livingston P,Scher HI

更新日期：2005-05-02 00:00:00

abstract：:Systemic and mucosal immune responses were effectively induced following the subcutaneous administration of Haemophilus influenzae type b oligosaccharide conjugated to diphtheria toxoid vaccine in a formulation containing the active form of vitamin D3. IgA and IgG antibodies with specificity for both the protein and o...

journal_title：Vaccine

authors： Enioutina EY,Visic D,McGee ZA,Daynes RA

更新日期：1999-08-06 00:00:00

abstract：:Chitosan is a polysaccharide capable of augmenting immune responses with a proven safety record in animals and humans. These properties make it a potentially attractive agent for the prevention and treatment of infectious disease. Infection by respiratory syncytial virus (RSV) is the leading cause of serious lower res...

journal_title：Vaccine

authors： Muralidharan A,Russell MS,Larocque L,Gravel C,Sauvé S,Chen Z,Li C,Chen W,Cyr T,Rosu-Myles M,Wang L,Li X

更新日期：2019-07-09 00:00:00

abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV) poses a great threat to public health due to its high mortality and transmission rate and wide geographical distribution. There is currently no specific antiviral therapy for CCHF. This study provides the first in-depth analysis of the cellular and humoral immune response ...

journal_title：Vaccine

authors： Mousavi-Jazi M,Karlberg H,Papa A,Christova I,Mirazimi A

更新日期：2012-09-28 00:00:00

abstract：:The development of a stable live attenuated Salmonella Enteritidis (SE) vaccine, resisting heat stress during transportation and storage in unequipped tropical and subtropical zones of the world, is highly recommended. Twelve stabilizers were individually supplemented into a 9 ml volume of sterile distilled water resu...

journal_title：Vaccine

authors： Barbour EK,Abdelnour A,Jirjis F,Faroon O,Farran MT

更新日期：2002-05-22 00:00:00

abstract：:The induction of antigen specific memory CD8(+) T cells in vivo is very important to new vaccines against infectious diseases. In the present study, we aimed to evaluate the immune responses of peptide-specific CD8(+) T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SA...

journal_title：Vaccine

authors： Zhao K,Wang H,Wu C

更新日期：2011-09-02 00:00:00

abstract：:Salmonella strains have great potential as live carriers of heterologous antigens to induce immunity against a variety of infectious diseases. However, the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, overattenuation or loss of e...

journal_title：Vaccine

authors： Tijhaar EJ,Zheng-Xin Y,Karlas JA,Meyer TF,Stukart MJ,Osterhaus AD,Mooi FR

更新日期：1994-08-01 00:00:00

abstract：:When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpr...

journal_title：Vaccine

authors： Smeeth L,Rodrigues LC,Hall AJ,Fombonne E,Smith PG

更新日期：2002-06-07 00:00:00

abstract：:Recipients of renal transplants were vaccinated with 20 ng hepatitis B surface antigen aluminium-adsorbed vaccine in order to gauge their resistance to hepatitis B infection, to which these patients are at high risk. The patients were given three 40 micrograms doses of the vaccine over a period of six months and their...

journal_title：Vaccine

authors： Feuerhake A,Muller R,Lauchart W,Pichlmayr R,Schmidt FW

更新日期：1984-12-01 00:00:00

abstract：:Aeromonas hydrophila, as a strong Gram-negative bacterium, can infect a wide range of freshwater fish, including common carp Cyprinus carpio, and cause the huge economic loss. To create the effective vaccine is the best way to control the outbreak of the disease caused by A. hydrophila. In this study, a live attenuate...

journal_title：Vaccine

authors： Jiang X,Zhang C,Zhao Y,Kong X,Pei C,Li L,Nie G,Li X

更新日期：2016-06-08 00:00:00

abstract：:An N-terminal peptide of the HIV-1 fusion peptide (FP) with eight amino acid residues (FP8) was conjugated to a recombinant Tetanus Toxoid Heavy Chain Fragment C (rTTHc) as a carrier protein to help boosting immunogenicity against HIV-1. In this rapid communication, a unique algorithm to determine FP-rTTHc conjugation...

journal_title：Vaccine

authors： Yang GJ,Yang Y,Shaddeau A,Cai CX,Li Y,Gulla K,Zhang Y,Ou L,Cooper JW,Lei QP

更新日期：2020-06-15 00:00:00

abstract：:Even though schistosomicidal agents and other control measures, including public hygiene and snail control exist, development of an efficacious vaccine still remains the most potentially powerful method for control of schistosomiasis. In our continuing efforts to develop a vaccine against schistosomiasis, we have sele...

journal_title：Vaccine

authors： Siddiqui AA,Pinkston JR,Quinlin ML,Saeed Q,White GL,Shearer MH,Kennedy RC

更新日期：2005-02-10 00:00:00

abstract：:The burden of influenza in children is increasingly appreciated; some middle-income countries are considering support for influenza vaccine programs. To support decision-making, methods to estimate the potential impact of proposed programs are needed. Using Thailand as a case-study, we present a model that uses survei...

journal_title：Vaccine

authors： Dawood FS,Fry AM,Muangchana C,Sanasuttipun W,Baggett HC,Chunsuttiwat S,Maloney SA,Simmerman JM

更新日期：2011-06-10 00:00:00

abstract：:Effective and safe novel adjuvants are of great interest to the vaccine research community. In this study, we describe our evaluation of adjuvant formulations containing a TLR9 agonist adjuvant (ISS1018) or ISCOMATRIX™ adjuvant for a two-dose regimen of hepatitis B virus surface antigen virus-like particle vaccine in ...

journal_title：Vaccine

authors： Freed DC,Towne VM,Casimiro DR,Zhao Q,Fu TM

更新日期：2011-11-21 00:00:00

abstract：:To assess human papillomavirus (HPV) prevalence and genotype distribution by age and cervical cytology/histology status among women undergoing routine gynecological examinations, and to discuss the possible impact on preventive strategies. Liquid-based cytology (LBC) samples were tested for HPV DNA, mRNA, and HPV geno...

journal_title：Vaccine

authors： Monsonego J,Zerat L,Syrjänen K,Zerat JC,Smith JS,Halfon P

更新日期：2012-07-27 00:00:00

abstract：BACKGROUND:In England, coverage for childhood vaccines have decreased since 2012/13 in the context of an increasingly visible anti-vaccination discourse. We determined whether anti-vaccination sentiment is the likely cause of this decline in coverage. METHODS:Descriptive study triangulating a range of data sources (va...

journal_title：Vaccine

authors： Edelstein M,Müller M,Ladhani S,Yarwood J,Salathé M,Ramsay M

更新日期：2020-07-14 00:00:00

abstract：:The prospective studies available today confirm the experience gained from several retrospective studies that TBE is a disease with a severe acute clinical course and considerable long-term morbidity. A defined post-encephalitic TBE syndrome exists, causing long-lasting morbidity that often affects the quality of life...

journal_title：Vaccine

authors： Haglund M,Günther G

更新日期：2003-04-01 00:00:00

abstract：:In many industrialized countries, hepatitis A incidence rates have declined steadily in the past decades. Since future cohorts of non-vaccinated elderly will lack protection against disease and the burden of hepatitis A is higher with increasing age, this could be an argument in favour of taking preventive measures su...

journal_title：Vaccine

authors： Suijkerbuijk AW,Lugnér AK,van Pelt W,Wallinga J,Verhoef LP,de Melker HE,de Wit GA

更新日期：2012-07-27 00:00:00

abstract：:We performed a genome-wide association study (GWAS) of antibody levels in a multi-ethnic group of 1071 healthy smallpox vaccine recipients. In Caucasians, the most prominent association was found with promoter SNP rs10489759 in the LOC647132 pseudogene on chromosome 1 (p=7.77×10(-8)). In African-Americans, we identifi...

journal_title：Vaccine

authors： Ovsyannikova IG,Kennedy RB,O'Byrne M,Jacobson RM,Pankratz VS,Poland GA

更新日期：2012-06-13 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired diarrhea, also known as C. difficile associated diarrhea. The two major toxins, toxin A and toxin B are produced by most C. difficile bacteria, but some strains, such as BI/NAP1/027 isolates, produce a third toxin called binary toxin. The precise biologic...

journal_title：Vaccine

authors： Wang S,Rustandi RR,Lancaster C,Hong LG,Thiriot DS,Xie J,Secore S,Kristopeit A,Wang SC,Heinrichs JH

更新日期：2016-03-04 00:00:00

abstract：:A choice-format, conjoint-analysis survey was developed and fielded to estimate how features of human papillomavirus (HPV) vaccines affect mothers' perceived benefit and stated vaccine uptake for daughters. Data were collected from a national sample of 307 U.S. mothers of girls aged 13-17 years who had not yet receive...

journal_title：Vaccine

authors： Brown DS,Johnson FR,Poulos C,Messonnier ML

更新日期：2010-02-17 00:00:00

abstract：:The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...

journal_title：Vaccine

authors： Hermsen CC,Verhage DF,Telgt DS,Teelen K,Bousema JT,Roestenberg M,Bolad A,Berzins K,Corradin G,Leroy O,Theisen M,Sauerwein RW

更新日期：2007-04-12 00:00:00

abstract：:The purpose of the present research work is to explore the potential of dendrosomes in genetic immunization against hepatitis B. Plasmid DNA encoding pRc/CMV-HBs[S] (5.6 kb), encoding the small region of the hepatitis B surface antigen, was complexed with 5th generation poly(propyleneimine) dendrimer (PPI) in differen...

journal_title：Vaccine

authors： Dutta T,Garg M,Jain NK

更新日期：2008-06-25 00:00:00

abstract：:Neisseria meningitidis is an important cause of bacterial meningitis and septicaemia with most disease caused by meningococci bearing serogroups A, B, C, Y and W-135 polysaccharides. Monovalent serogroup C conjugate vaccines have become established in the immunisation programmes in many countries and the first quadriv...

journal_title：Vaccine

authors： Pace D,Pollard AJ,Messonier NE

更新日期：2009-06-24 00:00:00

abstract：:A human influenza B/Lee/40 virus was cold-adapted by serial passages in embryonated chicken eggs, at progressively lower temperatures, for possible use as a future influenza B vaccine donor strain. Temperature sensitive and cold-adapted phenotypes were achieved as a consequence of the adaptation process. It was determ...

journal_title：Vaccine

authors： Seo SU,Byun YH,Lee EY,Jung EJ,Jang YH,Kim HA,Ha SH,Lee KH,Seong BL

更新日期：2008-02-13 00:00:00