Mothers' preferences and willingness to pay for vaccinating daughters against human papillomavirus.


:A choice-format, conjoint-analysis survey was developed and fielded to estimate how features of human papillomavirus (HPV) vaccines affect mothers' perceived benefit and stated vaccine uptake for daughters. Data were collected from a national sample of 307 U.S. mothers of girls aged 13-17 years who had not yet received an HPV vaccine. Preferences for four features of HPV vaccines were evaluated: protection against cervical cancer, protection against genital warts, duration of protection, and cost. We estimate that mean maximum willingness-to-pay (WTP)-an economic measure of the total benefits to consumers-for current HPV vaccine technology ranges between $560 and $660. All vaccine features were statistically significant determinants of WTP and uptake. Mothers were willing to pay $238 more for a vaccine that provides 90% protection for genital warts relative to a vaccine that provides no protection against warts. WTP for lifetime protection vs. 10 years protection was $245. Mothers strongly valued greater cervical cancer efficacy, with 100% protection against cervical cancers the most desired feature overall. Adding a second HPV vaccine choice to U.S. consumers' alternatives is predicted to increase stated uptake by 16%. Several features were significantly associated with stated choices and uptake: age of mother, race/ethnicity, household income, and concern about HPV risks. These findings provide new data on how HPV vaccines are viewed and valued by mothers, and how uptake may change in the context of evolving vaccine technology and as new data are reported on duration and efficacy.






Brown DS,Johnson FR,Poulos C,Messonnier ML




Has Abstract


2010-02-17 00:00:00
















  • Pharmacies versus doctors' offices for adolescent vaccination.

    abstract:PURPOSE:We sought to understand the relative advantage of pharmacies compared to doctors' offices for delivering HPV vaccination to adolescents. METHODS:Participants were a national sample of 1500 U.S. parents of adolescents ages 11-17 recruited in 2014-15. In an online survey, items informed by Diffusion of Innovatio...


    pub_type: 杂志文章


    authors: Shah PD,Marciniak MW,Golden SD,Trogdon JG,Golin CE,Brewer NT

    更新日期:2018-06-07 00:00:00

  • ISCOM vaccine induced protection against a lethal challenge with a human H5N1 influenza virus.

    abstract::Recently avian influenza A viruses of the H5N1 subtype were shown to infect humans in the Hong Kong area, resulting in the death of six people. Although these viruses did not efficiently spread amongst humans, these events illustrated that influenza viruses of subtypes not previously detected in humans could be at the...


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    authors: Rimmelzwaan GF,Claas EC,van Amerongen G,de Jong JC,Osterhaus AD

    更新日期:1999-03-17 00:00:00

  • Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children

    abstract:INTRODUCTION:Ghana introduced monovalent rotavirus vaccine in April 2012. We sought to determine the long-term impact of routine rotavirus vaccination on rotavirus gastroenteritis hospitalizations in Ghana during the first 4 years following rotavirus vaccine introduction. METHODS:Active sentinel surveillance for acute...


    pub_type: 杂志文章


    authors: Enweronu-Laryea CC,Armah G,Sagoe KW,Ansong D,Addo-Yobo E,Diamenu SK,Mwenda JM,Parashar UD,Tate JE

    更新日期:2018-11-12 00:00:00

  • Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice.

    abstract::A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(DL-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine. B...


    pub_type: 杂志文章


    authors: Luo Y,O'Hagan D,Zhou H,Singh M,Ulmer J,Reisfeld RA,James Primus F,Xiang R

    更新日期:2003-05-16 00:00:00

  • SOCS1 downregulation in dendritic cells promotes memory T-cell responses.

    abstract::SOCS1-1 is crucial for control of immune cell cytokine expression, including those cytokines known to enable memory T-cell formation and homeostasis. In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8(+) T memory cells and ant...


    pub_type: 杂志文章


    authors: Aldrich M,Sanders D,Lapteva N,Huang XF,Chen SY

    更新日期:2008-02-20 00:00:00

  • Assessing vaccine potency using TCRmimic antibodies.

    abstract::Dendritic cells (DCs) are highly specialized antigen-presenting cells of the immune system that are efficient at presenting peptide-antigen for the activation of T cells and are often the cell type of choice for vaccine targeting by virtue of high expression levels of MHC and costimulatory molecules. Since the level o...


    pub_type: 杂志文章


    authors: Neethling FA,Ramakrishna V,Keler T,Buchli R,Woodburn T,Weidanz JA

    更新日期:2008-06-13 00:00:00

  • Vaccine-induced host responses against very virulent Marek's disease virus infection in the lungs of chickens.

    abstract::The aim of this study was to investigate the kinetics of virus replication and cellular responses in the lungs following infection with Marek's disease virus (MDV) and/or vaccination with herpesvirus of turkey (HVT) via the respiratory route. Chickens vaccinated with HVT and challenged with MDV had a higher accumulati...


    pub_type: 杂志文章


    authors: Haq K,Abdul-Careem MF,Shanmuganthan S,Thanthrige-Don N,Read LR,Sharif S

    更新日期:2010-08-02 00:00:00

  • Influenza and pertussis vaccination in pregnancy: Portrayal in online media articles and perceptions of pregnant women and healthcare professionals.

    abstract:INTRODUCTION:Online media may influence women's decision to undergo vaccination during pregnancy. The aims of this mixed-methods study were to: (1) examine the portrayal of maternal vaccination in online media and (2) establish the perceived target of vaccine protection as viewed by pregnant women and maternity healthc...


    pub_type: 杂志文章


    authors: Wilcox CR,Bottrell K,Paterson P,Schulz WS,Vandrevala T,Larson HJ,Jones CE

    更新日期:2018-11-29 00:00:00

  • Multilevel correlates for human papillomavirus vaccination of adolescent girls attending safety net clinics.

    abstract:BACKGROUND:Adolescent HPV vaccination in minority and low income populations with high cervical cancer incidence and mortality could reduce disparities. Safety-net primary care clinics are a key delivery site for improving vaccination rates in these populations. PURPOSE:To examine prevalence of HPV initiation (≥ 1 dos...


    pub_type: 杂志文章


    authors: Tiro JA,Pruitt SL,Bruce CM,Persaud D,Lau M,Vernon SW,Morrow J,Skinner CS

    更新日期:2012-03-16 00:00:00

  • Development of an oral vaccine for immunisation of rainbow trout (Oncorhynchus mykiss) against viral haemorrhagic septicaemia.

    abstract::In the European Union Viral Haemorrhagic Septicaemia (VHS) eradication is still based on stamping out. Due to the lack of effective low cost vaccines immune prophylaxis is currently not used to combat VHS. This paper describes a new oral delivery method for immunisation of trout with attenuated virus. The vaccine cons...


    pub_type: 杂志文章


    authors: Adelmann M,Köllner B,Bergmann SM,Fischer U,Lange B,Weitschies W,Enzmann PJ,Fichtner D

    更新日期:2008-02-06 00:00:00

  • VennVax, a DNA-prime, peptide-boost multi-T-cell epitope poxvirus vaccine, induces protective immunity against vaccinia infection by T cell response alone.

    abstract::The potential for smallpox to be disseminated in a bioterror attack has prompted development of new, safer smallpox vaccination strategies. We designed and evaluated immunogenicity and efficacy of a T-cell epitope vaccine based on conserved and antigenic vaccinia/variola sequences, identified using bioinformatics and ...


    pub_type: 杂志文章


    authors: Moise L,Buller RM,Schriewer J,Lee J,Frey SE,Weiner DB,Martin W,De Groot AS

    更新日期:2011-01-10 00:00:00

  • Assessment of indirect protection from maternal influenza immunization among non-vaccinated household family members in a randomized controlled trial in Sarlahi, Nepal.

    abstract::Influenza is a significant cause of morbidity and mortality worldwide, and the World Health Organization highly recommends maternal vaccination during pregnancy. The indirect effect of maternal vaccination on other close contacts other than newborns is unknown. To evaluate this, we conducted a nested substudy between ...


    pub_type: 杂志文章


    authors: Newman KL,Stewart LM,Scott EM,Tielsch JM,Englund JA,Khatry SK,Mullany LC,LeClerq SC,Shrestha L,Kuypers JM,Chu HY,Katz J

    更新日期:2020-10-07 00:00:00

  • Influence of adjuvant-active peptidoglycan monomer on specific T cell responses in mice.

    abstract::Peptidoglycan monomer (PGM) originating from Brevibacterium divaricatum is a non-toxic, non-pyrogenic, water-soluble immunostimulator. It potentiates humoral immune response to ovalbumin (OVA) in mice upregulating both immunoglobulin (IgG) 1 and IgG2a antibody subclasses. This study concerns the influence of PGM on T ...


    pub_type: 杂志文章


    authors: Halassy Spoljar B,Cimbora T,Hanzl-Dujmović I,Dojnović B,Sabioncello A,Krstanović M,Tomasić J

    更新日期:2002-10-04 00:00:00

  • Pertussis before and after the introduction of acellular pertussis vaccines in Finland.

    abstract::In Finland, the whole-cell pertussis vaccine was replaced with acellular pertussis vaccine in the national immunisation schedule in 2005. Adolescent booster vaccinations were also included in the programme. The aim of this study was to evaluate the effects of these changes on the epidemiology and strain characteristic...


    pub_type: 杂志文章


    authors: Elomaa A,He Q,Minh NN,Mertsola J

    更新日期:2009-09-04 00:00:00

  • A novel mouse model for immunogenic evaluation of human HBV vaccines.

    abstract::To prepare a human HBV vaccine, investigators need an animal model that can help them screen and prioritize vaccine candidates. In this study, HBV/HLA-A2.1 double transgenic mice (dTg), confirmed by analysis of genomic integration and by observation of long-term expression of HBV and HLA genes, were generated for the ...


    pub_type: 杂志文章


    authors: Guo Y,Ren D,He X,Wang F,Jiang L,Song S,He Y,Sun S

    更新日期:2009-09-18 00:00:00

  • Bacillus subtilis spores as adjuvants for DNA vaccines.

    abstract::Recently, Bacillus subtilis spores were shown to be endowed with strong adjuvant capacity when co-administered with purified antigenic proteins. In the present study we assessed whether spores possess adjuvant properties when combined with DNA vaccines. We showed that B. subtilis spores promoted the activation of dend...


    pub_type: 杂志文章


    authors: Aps LR,Diniz MO,Porchia BF,Sales NS,Moreno AC,Ferreira LC

    更新日期:2015-05-11 00:00:00

  • Towards the rational design of Th1 adjuvants.

    abstract::Finding adjuvants in order to enhance immune responses against target immunogens has been a major and recurrent issue for the vaccine industry. It is yet to be solved, most particularly in the context of a growing interest in designing new types of vaccines capable of eliciting Th1 immune responses. A review of synthe...


    pub_type: 杂志文章,评审


    authors: Moingeon P,Haensler J,Lindberg A

    更新日期:2001-08-14 00:00:00

  • Immunogenic virus-like particles continuously expressed in mammalian cells as a veterinary rabies vaccine candidate.

    abstract::Rabies is one of the most lethal infectious diseases in the world, with a mortality approaching 100%. There are between 60,000 and 70,000 reported annual deaths, but this is probably an underestimation. Despite the fact that there are vaccines available for rabies, there is a real need of developing more efficacious a...


    pub_type: 杂志文章


    authors: Fontana D,Kratje R,Etcheverrigaray M,Prieto C

    更新日期:2015-08-20 00:00:00

  • Infectious bursal disease virus rescued efficiently with 3' authentic RNA sequence induces humoral immunity without bursal atrophy.

    abstract::A reverse genetics infectious bursal disease virus (RG-IBDV) that contained authentic 3' RNA sequence was characterized both in vitro and in vivo. LP1-IBDV, a cell line-adapted IBDV strain variant E (VE) was used as the parent virus for constructing viral cDNA clones. Authentic 3' RNA sequence was generated by using c...


    pub_type: 杂志文章


    authors: Mosley YY,Wu CC,Lin TL

    更新日期:2013-01-11 00:00:00

  • Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic.

    abstract:INTRODUCTION:HPV vaccine uptake is lowest among young adults. Little is known about the most effective way to decrease missed opportunities (MO) and increase uptake of the vaccine in this vulnerable population. OBJECTIVES:To determine the impact of a clinical intervention bundle on the rate of MO and uptake of the vac...


    pub_type: 杂志文章


    authors: Deshmukh U,Oliveira CR,Griggs S,Coleman E,Avni-Singer L,Pathy S,Shapiro ED,Sheth SS

    更新日期:2018-06-14 00:00:00

  • Reduction of disulfide bonds in Plasmodium falciparum gp195 abolishes the production of growth-inhibitory antibodies.

    abstract::The role of disulfide-dependent protein conformation of the 195,000 kDa Plasmodium falciparum merozoite surface glycoprotein in the induction of biologically active antibodies was investigated. Serum samples from rabbits immunized with native gp195 had a mean ELISA titre of 1/560,000 and a mean in vitro parasite growt...


    pub_type: 杂志文章


    authors: Locher CP,Tam LQ

    更新日期:1993-01-01 00:00:00

  • Potential of Mw as a prophylactic vaccine against pulmonary tuberculosis.

    abstract::Mycobacterium w (Mw), is a cultivable, non-pathogenic mycobacterium and has been tried extensively as an immunomodulator in leprosy. This has been found to be safe and has shown beneficial immunoprophylactic effect in population based, double blind placebo controlled trials in North India. These effects were also obse...


    pub_type: 杂志文章,随机对照试验


    authors: Katoch K,Singh P,Adhikari T,Benara SK,Singh HB,Chauhan DS,Sharma VD,Lavania M,Sachan AS,Katoch VM

    更新日期:2008-02-26 00:00:00

  • Neuraminidase inhibiting antibody responses in pigs differ between influenza A virus N2 lineages and by vaccine type.

    abstract::The neuraminidase (NA) protein of influenza A viruses (IAV) has important functional roles in the viral replication cycle. Antibodies specific to NA can reduce viral replication and limit disease severity, but are not routinely measured. We analyzed NA inhibiting (NI) antibody titers in serum and respiratory specimens...


    pub_type: 杂志文章


    authors: Sandbulte MR,Gauger PC,Kitikoon P,Chen H,Perez DR,Roth JA,Vincent AL

    更新日期:2016-07-19 00:00:00

  • Use of administrative records to assess pneumococcal conjugate vaccine impact on pediatric meningitis and pneumonia hospitalizations in Rwanda.

    abstract:BACKGROUND:Ongoing surveillance is critical to assessing pneumococcal conjugate vaccine (PCV) impact over time. However, robust prospective studies are difficult to implement in resource-poor settings. We evaluated retrospective use of routinely collected data to estimate PCV impact in Rwanda. METHODS:We collected dat...


    pub_type: 杂志文章


    authors: Gatera M,Uwimana J,Manzi E,Ngabo F,Nwaigwe F,Gessner BD,Moïsi JC

    更新日期:2016-10-17 00:00:00

  • Vaccination with human papillomavirus type 16-derived peptides using a tattoo device.

    abstract::Tattooing has been shown to be very efficient at inducing immunity by vaccination with DNA vaccines. In this study, we examined the usability of tattooing for delivery of peptide vaccines. We compared tattooing with subcutaneous (s.c.) needle injection using peptides derived from human papillomavirus type 16 (HPV16) p...


    pub_type: 杂志文章


    authors: Pokorná D,Poláková I,Kindlová M,Dusková M,Ludvíková V,Gabriel P,Kutinová L,Müller M,Smahel M

    更新日期:2009-06-02 00:00:00

  • An assessment of shedding with the oral rabies virus vaccine strain SPBN GASGAS in target and non-target species.

    abstract::A safety requirement for live vaccines is investigating possible shedding in recipients since the presence of replication competent vaccine in secretions could result in direct and indirect horizontal transmission. This is especially relevant for oral rabies vaccine baits that are deliberately distributed into the env...


    pub_type: 杂志文章


    authors: Vos A,Freuling C,Ortmann S,Kretzschmar A,Mayer D,Schliephake A,Müller T

    更新日期:2018-02-01 00:00:00

  • The effect of pneumococcal conjugate vaccines on the incidence of invasive pneumococcal disease caused by ten non-vaccine serotypes in Denmark.

    abstract:BACKGROUND:Surveillance data on invasive pneumococcal disease (IPD) in Denmark (1999-2014) was analysed regarding the incidence and age-distribution due to ten selected non-PCV serotypes (10-Non-PCV). The effect of PCV-7 and PCV-13 vaccines on the 10-Non-PCV IPD incidence was examined. METHODS:IPD cases caused by sero...


    pub_type: 杂志文章


    authors: Slotved HC,Dalby T,Hoffmann S

    更新日期:2016-02-03 00:00:00

  • Burden of rotavirus disease and cost-effectiveness of universal vaccination in the Province of Genoa (Northern Italy).

    abstract::Rotavirus is acknowledged to be a major cause of acute gastroenteritis in infants and young children. As gastroenteritis due to rotavirus is a public health problem and two new vaccines are currently available, we investigated the rotavirus burden and developed a cost-effectiveness analysis, using data collected in th...


    pub_type: 杂志文章


    authors: Panatto D,Amicizia D,Ansaldi F,Marocco A,Marchetti F,Bamfi F,Giacchino R,Tacchella A,Del Buono S,Gasparini R

    更新日期:2009-05-26 00:00:00

  • Safety, tolerability and efficacy of intradermal rabies immunization with DebioJect™.

    abstract::In a single-center study, 66 healthy volunteers aged between 18 and 50years were randomized to be immunized against rabies with three different injection routes: intradermal with DebioJect™ (IDJ), standard intradermal with classical needle (IDS), also called Mantoux method, and intramuscular with classical needle (IM)...


    pub_type: 杂志文章


    authors: Vescovo P,Rettby N,Ramaniraka N,Liberman J,Hart K,Cachemaille A,Piveteau LD,Zanoni R,Bart PA,Pantaleo G

    更新日期:2017-03-27 00:00:00

  • Physicochemical and immunological characterization of recombinant host-protective antigen (VP2) of infectious bursal disease virus.

    abstract::Small fusions to the N-terminal end of the host-protective antigen (VP2) of infectious bursal disease virus lead to stable expression of VP2 in Escherichia coli and yeast, and reduce the levels of inclusion body formation in E. coli in comparison to VP2 constructs with larger N-terminal fusions. VP2 produced with smal...


    pub_type: 杂志文章


    authors: Azad AA,McKern NM,Macreadie IG,Failla P,Heine HG,Chapman A,Ward CW,Fahey KJ

    更新日期:1991-10-01 00:00:00