Abstract:
:Schmallenberg virus (SBV), which emerged in 2011 in Central Europe and subsequently spread very rapidly throughout the continent, affects predominantly ruminants. SBV is transmitted by insect vectors, and therefore vaccination is one of the major tools of disease control. Only recently, a domain connected to virus neutralization has been identified at the amino-terminal part of the viral envelope protein Gc. Here, this Gc domain delivered by recombinant EHV-1 or MVA vector viruses was tested in a vaccination-challenge trial in cattle, one of the major target species of SBV. The EHV-1-based vaccine conferred protection in two of four animals, whereas immunization using the MVA vector vaccine efficiently induced an SBV-specific antibody response and full protection against SBV challenge infection in all the vaccinated animals. Moreover, due to the absence of antibodies against SBVs N-protein, both vector vaccines enable the differentiation between vaccinated and field-infected animals making them to a promising tool to control SBV spread as well as to prevent disease in domestic ruminants.
journal_name
Vaccinejournal_title
Vaccineauthors
Wernike K,Mundt A,Link EK,Aebischer A,Schlotthauer F,Sutter G,Fux R,Beer Mdoi
10.1016/j.vaccine.2018.07.047subject
Has Abstractpub_date
2018-08-16 00:00:00pages
5116-5123issue
34eissn
0264-410Xissn
1873-2518pii
S0264-410X(18)31016-8journal_volume
36pub_type
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