Abstract：
:Understanding how genetics influences inter-individual variation of antibody titers in response to measles vaccination is vital to understanding possible sources of vaccine failure as well as improved vaccine development. Although it is recognized that both the human leukocyte antigen (HLA) genes and the immunoglobulin allotype genes play significant roles in immune response, there is significant variation in antibody titers that is not explained by these genes. To obtain a more complete estimate of the role of the entire genome, we used a large panel of single nucleotide polymorphisms to estimate the heritability of antibody response to measles vaccine. Based on 935 subjects with European ancestry, we estimated the heritability to be 49% (standard error 0.17). We also estimated the heritability attributable to each chromosome, and found a large range in chromosome-specific heritabilities. Notably, chromosome 1 had the largest estimate (28%), while chromosome 6, which harbors HLA, had an estimated heritability of 13%. Compared with a prior study of twins in the same community, which resulted in a heritability estimate of 88.5%, our study suggests there are either many rare genetic variants, or many common genetic variants of small effect sizes that contribute to variations of antibody titers in response to measles vaccine.
journal_name
Vaccinejournal_title
Vaccineauthors
Schaid DJ,Haralambieva IH,Larrabee BR,Ovsyannikova IG,Kennedy RB,Poland GAdoi
10.1016/j.vaccine.2017.01.078subject
Has Abstractpub_date
2017-03-07 00:00:00pages
1390-1394issue
10eissn
0264-410Xissn
1873-2518pii
S0264-410X(17)30158-5journal_volume
35pub_type
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