Abstract：
:Anti-angiogenesis represents an indispensible strategy for cancer therapy. As a strictly endothelial-specific adhesion molecule, vascular endothelial cadherin (VE-cadherin, VE-cad) is a promising anti-angiogenesis target. In this study a recombinant adenovirus vector modified with mannan was used to deliver VE-cad (AdVEC-m) and we tried to explore its feasibility as an antitumour agent in mouse cancer models. The immunogenic delivery of VE-cad resulted in obvious prophylactic and therapeutic inhibition of tumour growth and prolonged survival in mice. In the meantime angiogenesis declined apparently within the tumours measured by immunohistochemistry staining and coated alginate bead assay in vivo. Anti-VE-cad antibodies were identified by western blot analysis and enzyme-linked immunosorbent assay (ELISA). VE-cad-specific T lymphocyte cytotoxicity responses (CTL) were detected by chromium (51Cr) release assay of splenocytes from AdVEC-m treated mice. These results demonstrate that mannan modification is able to enhance antigen delivery and immune responses, and the way of immunogenic delivery (AdVEC-m) is expected to provide an attractive vaccine strategy for cancer immunotherapy.
journal_name
Vaccinejournal_title
Vaccineauthors
Zhao Z,Yao Y,Ding Z,Chen X,Xie K,Luo Y,Zhang J,Chen X,Wu X,Xu J,Zhao J,Niu T,Liu J,Li Q,Zhang W,Wen Y,Su J,Hu B,Bu H,Wei Y,Wu Ydoi
10.1016/j.vaccine.2011.03.109subject
Has Abstractpub_date
2011-06-06 00:00:00pages
4218-24issue
25eissn
0264-410Xissn
1873-2518pii
S0264-410X(11)00512-3journal_volume
29pub_type
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