Abstract：
:Phage lambda particles displaying four immunodominant regions of porcine Circovirus 2 (PCV2) capsid protein (LDP-D-CAP) was shown to be immunogenic in pigs. The immunodominant regions were fused to the carboxyl-terminal of lambda head protein D. Expression of D-CAP on lambda display particles was demonstrated by ELISA and Western blots. Pigs receiving LDP-D-CAP, without incorporating adjuvant, showed significant anti-PCV2 immune response following the primary vaccination. The LDP-D-CAP preparation induced PCV2 neutralizing antibodies. Delayed type hypersensitivity (DTH) reaction scores revealed that the immunized pigs were hypersensitive to both lambda phage and PCV2 antigens. The LDP-D-CAP elicited both cellular and humoral immune responses. Neither LDP-D-CAP nor the lambda control elicited any untoward local or systemic reactions following immunization. These studies produced the first potential phage vaccine to porcine Circovirus 2.
journal_name
Vaccinejournal_title
Vaccineauthors
Gamage LN,Ellis J,Hayes Sdoi
10.1016/j.vaccine.2009.08.019subject
Has Abstractpub_date
2009-11-05 00:00:00pages
6595-604issue
47eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)01195-5journal_volume
27pub_type
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