Abstract：
:A recombinant vector vaccine uses an attenuated virus, bacterium, or parasite as the carrier to express a heterologous antigen(s). Many recombinant vaccine vectors and related vaccines have been developed and extensively investigated. To compare and better understand recombinant vectors and vaccines, we have generated Vaxvec (http://www.violinet.org/vaxvec), the first web-based database that stores various recombinant vaccine vectors and those experimentally verified vaccines that use these vectors. Vaxvec has now included 59 vaccine vectors that have been used in 196 recombinant vector vaccines against 66 pathogens and cancers. These vectors are classified to 41 viral vectors, 15 bacterial vectors, 1 parasitic vector, and 1 fungal vector. The most commonly used viral vaccine vectors are double-stranded DNA viruses, including herpesviruses, adenoviruses, and poxviruses. For example, Vaxvec includes 63 poxvirus-based recombinant vaccines for over 20 pathogens and cancers. Vaxvec collects 30 recombinant vector influenza vaccines that use 17 recombinant vectors and were experimentally tested in 7 animal models. In addition, over 60 protective antigens used in recombinant vector vaccines are annotated and analyzed. User-friendly web-interfaces are available for querying various data in Vaxvec. To support data exchange, the information of vaccine vectors, vaccines, and related information is stored in the Vaccine Ontology (VO). Vaxvec is a timely and vital source of vaccine vector database and facilitates efficient vaccine vector research and development.
journal_name
Vaccinejournal_title
Vaccineauthors
Deng S,Martin C,Patil R,Zhu F,Zhao B,Xiang Z,He Ydoi
10.1016/j.vaccine.2015.07.113subject
Has Abstractpub_date
2015-11-27 00:00:00pages
6938-46issue
48eissn
0264-410Xissn
1873-2518pii
S0264-410X(15)01284-0journal_volume
33pub_type
杂志文章相关文献
VACCINE文献大全abstract：BACKGROUND:Pneumococcal conjugate vaccines (PCV) were first licensed for use with 3 primary doses in infancy and a booster dose. The evidence for the effects of different schedules was examined in this systematic review and meta-analysis. METHODS:We searched 12 databases and trial registers up to March 2010. We select...
journal_title：Vaccine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.vaccine.2011.07.042
更新日期：2011-12-06 00:00:00
abstract：BACKGROUND:To evaluate the potential public health impact of the live attenuated tetravalent Sanofi Pasteur dengue vaccine (CYD-TDV) we analyzed data from the reported clinical trials to calculate vaccine preventable disease incidence (VPDI) and number needed to vaccinate (NNV) based on the licensure indication for per...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.03.017
更新日期：2016-04-29 00:00:00
abstract：INTRODUCTION:S. aureus is a pathogen to which individuals are exposed shortly after birth, with immune responses to S. aureus increasing during childhood. There is marked heterogeneity between the anti- S. aureus immune responses of different humans, the basis of which is not fully understood. METHODS:To investigate d...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.11.063
更新日期：2019-01-14 00:00:00
abstract：:Live cold-adapted recombinant bivalent vaccine of influenza type A was studied in a controlled field trial in 1982-1983 among nearly 30,000 children 3-15 years old. The bivalent vaccine consisted of recombinants 47/25/1 (H1N1) and 47/7/2 (H3N2) of wild-type viruses A/Brazil/11/78 (H1N1) and A/Bangkok/1/79 (H3N2) with ...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/0264-410x(86)90049-6
更新日期：1986-06-01 00:00:00
abstract：:In Finland, the whole-cell pertussis vaccine was replaced with acellular pertussis vaccine in the national immunisation schedule in 2005. Adolescent booster vaccinations were also included in the programme. The aim of this study was to evaluate the effects of these changes on the epidemiology and strain characteristic...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.07.010
更新日期：2009-09-04 00:00:00
abstract：:The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to per...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/0264-410x(95)00091-e
更新日期：1995-11-01 00:00:00
abstract：:Ethnicity may be associated with the incidence of pneumococcal infections and the frequency of protective vaccine responses. Earlier studies have suggested that HIV-infected persons of black ethnicity develop less robust immune responses to pneumococcal vaccination that may relate to their higher incidence of invasive...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.09.056
更新日期：2010-11-10 00:00:00
abstract：:Integration of health services brings together common functions within and between organizations to solve common problems, developing a commitment to a shared vision and goals, and using common technologies and resources to achieve these goals. Integration has been the frustrated rally call of Primary Health Care for ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2008.02.032
更新日期：2008-04-07 00:00:00
abstract：:Porcine epidemic diarrhea (PED) is an important re-emergent infectious disease and inflicts huge economic losses to the swine industry worldwide. To meet the pressing need of developing a safe and cost-efficient PED maternal vaccine, we generated three PED subunit vaccine candidates, using recombined Salmonella flagel...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.01.086
更新日期：2018-03-07 00:00:00
abstract：:HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2005.09.047
更新日期：2006-03-06 00:00:00
abstract：:sLAG-3 (IMP321), a natural high affinity ligand for MHC class II, was tested for safety, tolerability and its ability to increase Th-1-type T cell responses to a commercial trivalent split influenza vaccine (Agrippal) in a phase I single-blinded, randomized, controlled clinical trial. Twenty healthy volunteers were fi...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2007.04.019
更新日期：2007-06-11 00:00:00
abstract：:The purpose of the present study was to compare serum and mucosal immune responses following either aerosol (Aer) or subcutaneous (SQ) measles immunization of Mexican school children. A cohort of 49 children from 6 to 7 years of age received either Aer ( n = 22) or SQ ( n = 27) Edmonston-Zagreb (EZ) measles vaccine. S...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.09.032
更新日期：2004-03-12 00:00:00
abstract：:Four Saanen goats were immunized with affinity purified gp135 surface glycoprotein (SU) of caprine arthritis-encephalitis virus isolate 79-63 (CAEV-63) and evaluated for homologous and crossreactive serum neutralizing antibodies. CAEV-63 neutralizing antibodies were detected in all goats after seven immunizations with...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00181-4
更新日期：2000-01-18 00:00:00
abstract：:An economic evaluation of reducing the age threshold for routine influenza vaccination in Spain from 65 to 50 years was performed. A probabilistic model was used to compare a policy based on a recommendation to vaccinate all adults aged 50-64 with the existing vaccination policy for that age group, during interpandemi...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.07.033
更新日期：2007-09-28 00:00:00
abstract：:Dengue is one of the most important mosquito-borne viral disease causing dengue fever and/or dengue shock syndrome/haemorrhagic fever. In some reports, the non-structural protein 1 (NS1) has been identified as a promising antigen for the development of vaccines against dengue virus (DENV). Apparently, it can elicit a ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.08.022
更新日期：2006-05-22 00:00:00
abstract：BACKGROUND:Development of influenza vaccines that do not use embryonated eggs as the substrate for vaccine production is a high priority. We conducted this study to determine the protective efficacy a recombinant, baculovirus-expressed seasonal trivalent influenza virus hemagglutinin (rHA0) vaccine (FluBlok(®)). METHO...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2011.07.128
更新日期：2011-10-13 00:00:00
abstract：:The predominant route of HIV infection is through the sexual transmission via M cells. Most of the peptide and protein vaccines show poor transport across the epithelial barrier and are commonly administered by parenteral route. In the present study four HIV peptides from envelope (gp 41-LZ (leucine zipper), gp 41-FD ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.06.031
更新日期：2005-12-01 00:00:00
abstract：:Previous studies with the malaria vaccine RTS,S/AS02(A) in young children in a malaria endemic area of Mozambique have shown it to have a promising safety profile and to reduce the risk of Plasmodium falciparum infection and disease. In this study, we assessed the antibody responses to the P. falciparum and hepatitis ...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2011.03.041
更新日期：2011-08-11 00:00:00
abstract：:The hypervariable region 1 (HVR1) of hepatitis C virus (HCV) may contain neutralizing epitopes. A chimpanzee in whom cross-reactive anti-HVR1 antibodies had been induced by immunization was challenged with heterologous HCV for clarifying whether cross-reactive anti-HVR1 antibodies can neutralize heterologous HCV. Acut...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00271-2
更新日期：2002-08-19 00:00:00
abstract：BACKGROUND:Cross-clade immunogenic stockpiled H5N1 vaccines may decrease the morbidity and transmission of infection during the initial phase of influenza pandemic. Meta-analysis of cross-reactive antibodies induced by oil-in-water emulsion adjuvanted (OWEA) influenza H5N1 virus monovalent vaccines with circulating het...
journal_title：Vaccine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.vaccine.2017.04.029
更新日期：2017-05-31 00:00:00
abstract：:Thirty-two rhesus monkeys were used to evaluate the dose response of a recombinant HEV vaccine, and the efficacy of the vaccine based on the ORF2 protein of the Pakistani strain for pre- and post-exposure vaccination against intravenous challenge with homologous or heterologous virus was examined. Post-exposure vaccin...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(97)00145-x
更新日期：1997-12-01 00:00:00
abstract：:Vaccination of children with aluminium sensitisation against diphtheria and tetanus presents a problem, since vaccine without aluminium against these potentially serious infectious diseases is no longer available. This case report presents a 7-month-old boy who, after his second immunisation with DTaP-IPV, developed a...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.03.013
更新日期：2004-11-15 00:00:00
abstract：:A booster dose of a formalin-inactivated, cell culture-propagated Rift Valley fever vaccine (TSI-GSD-200) was administered without significant reactogenicity to 60 volunteers 18 months after they received a three dose primary series. Blood was drawn for serological testing prior to boosting and 10, 49, and 180 days th...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(85)90060-x
更新日期：1985-06-01 00:00:00
abstract：:Previous work, in sheep vaccinated with emergency foot-and-mouth disease (FMD) vaccine, indicated the benefit of increasing the antigen payload in inhibiting local virus replication and consequently persistence following an indirect aerosol challenge with a virus homologous to the vaccine strain. The work presented he...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.01.037
更新日期：2006-04-12 00:00:00
abstract：:CD8(+) T-cell responses provide beneficial antiviral immunity against human immunodeficiency virus 1 (HIV-1). In this study, we show that intragastric vaccination with a Salmonella HIV-1 Env DNA vaccine vector generates Env-specific CD8(+) T-cells, both in mucosal and systemic lymphoid tissue. By contrast, intramuscul...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00330-9
更新日期：2001-11-12 00:00:00
abstract：:Travellers often present late for the third dose of hepatitis B vaccination and measuring anti-HBs serology is common practice to ensure that these individuals are protected. We assessed the adequacy of immune response in 86 healthy travellers who had their third dose of hepatitis B (HB) vaccine performed more than 1 ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.12.053
更新日期：2007-04-30 00:00:00
abstract：BACKGROUND:Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. METHODS:We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental cord:maternal ratios (GMRs) and proportions of samples with protect...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.01.033
更新日期：2014-03-14 00:00:00
abstract：:The efficacy of a novel inactivated Lawsonia intracellularis vaccine, Porcilis® Lawsonia, was compared to that of a commercially available live attenuated vaccine in three experimental vaccination-challenge studies in pigs. The efficacy of the new vaccine was further tested under field conditions on a farm with a hist...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.02.067
更新日期：2019-04-03 00:00:00
abstract：:Biodegradable nanoparticles coated with proteins represent a promising method for in vivo delivery of vaccines. Here we used a rabbit model to compare quantitatively and qualitatively the antibody responses induced by poly(D,L-lactide) nanoparticles (PLA) and by emulsion adjuvant MF59 using three HIV-1 antigens: p24ga...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.08.060
更新日期：2007-10-23 00:00:00
abstract：:Irradiation of Androctonus australis hector venom using a dose of 2 kGy has successfully abolished toxicity without reducing its antigenic or immunogenic properties. Toxicity of irradiated antigen was abolished until 20 times of LD(50) of native venom. Analysis of physiopathological effects induced by native and irrad...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.09.044
更新日期：2011-11-08 00:00:00
