Abstract：
:Thirty-two rhesus monkeys were used to evaluate the dose response of a recombinant HEV vaccine, and the efficacy of the vaccine based on the ORF2 protein of the Pakistani strain for pre- and post-exposure vaccination against intravenous challenge with homologous or heterologous virus was examined. Post-exposure vaccination did not protect animals against hepatitis. Although primates vaccinated twice with 50-microgram, 10-microgram, 2-microgram, or 0.4-microgram doses of the recombinant 55 kDa ORF-2 protein were infected, they were protected from hepatitis when they were challenged with very high doses of the homologous strain of HEV. Primates vaccinated twice with a 50 micrograms dose of the recombinant protein were protected from hepatitis after heterologous challenge with the Mexican strain, the strain of HEV most genetically distant from the Pakistani strain.
journal_name
Vaccinejournal_title
Vaccineauthors
Tsarev SA,Tsareva TS,Emerson SU,Govindarajan S,Shapiro M,Gerin JL,Purcell RHdoi
10.1016/s0264-410x(97)00145-xsubject
Has Abstractpub_date
1997-12-01 00:00:00pages
1834-8issue
17-18eissn
0264-410Xissn
1873-2518pii
S0264-410X(97)00145-Xjournal_volume
15pub_type
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