Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction.

abstract：:Cytokines play an important role in the immune response to live measles virus immunization. To gain further insight into the cytokine production profile in response to measles vaccination, we studied interferon-gamma (IFN-gamma), tumor necrosis factor (TNF-alpha), soluble IL-2 receptor (sIL-2R), interleukin-2 (IL-2), ...

journal_title：Vaccine

authors： Ovsyannikova IG,Reid KC,Jacobson RM,Oberg AL,Klee GG,Poland GA

更新日期：2003-09-08 00:00:00

abstract：:Outer membrane protein PhoE of Escherichia coli was used for the expression of antigenic determinants of foot-and-mouth disease virus. Five hybrid PhoE proteins were constructed containing different combinations of two antigenic determinants of VP1 protein of the virus. The hybrid proteins were expressed in two E. col...

journal_title：Vaccine

authors： Agterberg M,Adriaanse H,Lankhof H,Meloen R,Tommassen J

更新日期：1990-02-01 00:00:00

abstract：:We have shown previously that expression library immunization is viable alternative approach to induce protective immunity against Neisseria meningitidis serogroup B. In this study we report that few rounds of library screening allow identification of protective pools of defined antigens. A previously reported protect...

journal_title：Vaccine

authors： Yero D,Pajón R,Pérez Y,Fariñas M,Cobas K,Diaz D,Solis RL,Acosta A,Brookes C,Taylor S,Gorringe A

更新日期：2007-07-09 00:00:00

abstract：:In order to establish a firm preventive measure for tick-borne encephalitis (TBE) in Japan, we evaluated the immune response of European vaccine against Japanese TBE virus strain (Oshima 5-10) for man and mouse. Furthermore, the efficacy of pre- and post-exposure protection by a polyclonal rabbit anti-TBE virus serum ...

journal_title：Vaccine

authors： Chiba N,Osada M,Komoro K,Mizutani T,Kariwa H,Takashima I

更新日期：1999-03-17 00:00:00

abstract：:The human immune defense system is composed of two distinct elements: innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically, effective vaccines have ...

journal_title：Vaccine

authors： Takahashi H

更新日期：2010-05-26 00:00:00

abstract：:Salmonella Enteritidis mutants with deletions in phoP, fliC or phoPfliC were tested for their virulence and their ability to induce parameters of the innate and adaptive immunity in addition to their potential for serological differentiation between vaccinated, non-vaccinated and infected chickens. The double phoPfliC...

journal_title：Vaccine

authors： Methner U,Barrow PA,Berndt A,Rychlik I

更新日期：2011-04-12 00:00:00

abstract：:The efficacy of immunization of a vaccine depends on an antigen, an adjuvant, and on the expression of multiple genes in the host. The responsiveness of various strains of mice to adjuvants is therefore dependent on their genetic background present as a complex, multigenic trait similarly as in man. We have recently d...

journal_title：Vaccine

authors： Di Marco S,Moisan J,Boghdady ML,Skamene E,Radzioch D

更新日期：2003-02-14 00:00:00

abstract：:This study aimed to evaluate the durability of the immunogenicity of MVA85A beyond infancy. Participants in an immunogenicity study of MVA85A administered at age of 4 months had additional evaluation 14 months after initial vaccination for IFN-γ ELISPOT responses to Ag85A peptide and ESAT6/CFP-10 and tuberculin skin t...

journal_title：Vaccine

authors： Odutola AA,Owolabi OA,Owiafe PK,McShane H,Ota MO

更新日期：2012-08-17 00:00:00

abstract：:Vaccination is the principal means used to control and treat porcine reproductive and respiratory syndrome virus (PRRSV) infection. An array of PRRS vaccine products is available in various regions of the world. However, despite extensive efforts, little progress has been made to improve efficacy since the first intro...

journal_title：Vaccine

authors： Murtaugh MP,Genzow M

更新日期：2011-10-26 00:00:00

abstract：:Here, monophosphoryl lipid A (MPLA) and aluminum salt (Alum) were introduced into a hyaluronic acid (HA)-based combination vaccine adjuvant for hepatitis B vaccine (HBV). Although Alum is a well-known hepatitis B vaccine adjuvant that induces an enhanced humoral immune response, it cannot induce the cellular immune re...

journal_title：Vaccine

authors： Moon SH,Shin EC,Noh YW,Lim YT

更新日期：2015-09-11 00:00:00

abstract：:The recovery of wild type and attenuated human parainfluenza type 3 (PIV3) recombinant viruses has made possible a new strategy to rapidly generate a live-attenuated vaccine virus fof PIV1. We previously replaced the coding sequences for the hemagglutinin-neuraminidase (HN) and fusion (F) proteins of PIV3 with those o...

journal_title：Vaccine

authors： Tao T,Skiadopoulos MH,Durbin AP,Davoodi F,Collins PL,Murphy BR

更新日期：1999-03-05 00:00:00

abstract：:Human papillomavirus (HPV) infection is highly prevalent and can lead to cancer; the development of safe and efficacious vaccines for HPV is a major public health concern. The two licensed HPV vaccines contain recombinant virus-like particles of HPV 16 and 18; one of such vaccines also protects against HPV types 6 and...

journal_title：Vaccine

authors： Giacomet V,Penagini F,Trabattoni D,Viganò A,Rainone V,Bernazzani G,Bonardi CM,Clerici M,Bedogni G,Zuccotti GV

更新日期：2014-09-29 00:00:00

abstract：:Herpes B virus (Cercopithecine herpesvirus 1) is endemic in captive macaque populations and poses a serious threat to humans who work with macaques or their tissues. A vaccine that could prevent or limit B virus infection in macaques would lessen occupational risk. To that end, a DNA vaccine plasmid expressing the B v...

journal_title：Vaccine

authors： Loomis-Huff JE,Eberle R,Lockridge KM,Rhodes G,Barry PA

更新日期：2001-09-14 00:00:00

abstract：:Immunogenicity and safety of a newly developed liquid DTwP-Hib/HepB-IPV hexavalent vaccine (EasySix™) was evaluated and compared with administration of commercially licensed Pentavac SD® (DTwP-HepB/Hib) and Imovax Polio® vaccine in an open-label, randomized multi-centric trial. 284 participants, aged 6-10weeks, random...

journal_title：Vaccine

authors： Mohanty L,Sharma S,Behera B,Panwar S,Paliwal C,Gupta A,Chilkoti DC,Singh A

更新日期：2018-04-19 00:00:00

abstract：:In this study, the haemolytic activities of Astragalus membranaceus saponins (AMS) and its adjuvant potentials on the cellular and humoral immune responses of ICR mice against OVA were evaluated. We determined the haemolytic activity of AMS using 0.5% rabbit red blood cell. AMS showed a slight haemolytic effect, with ...

journal_title：Vaccine

authors： Yang ZG,Sun HX,Fang WH

更新日期：2005-10-25 00:00:00

abstract：:Currently, infections of hand, foot and mouth disease (HFMD) due to Human Enterovirus 71 (EV71) cannot be prevented or treated, as there are no suitable vaccines or antiviral drugs. This study aimed to identify potential vaccine candidates for EV71 using in silico analysis of its viral capsid proteins. A combined in s...

journal_title：Vaccine

authors： Kirk K,Poh CL,Fecondo J,Pourianfar H,Shaw J,Grollo L

更新日期：2012-11-19 00:00:00

abstract：:Although the direct health impact of Coronavirus disease (COVID-19) pandemic on child health is low, there are indirect impacts across many aspects. We compare childhood vaccine uptake in three types of healthcare facilities in Singapore - public primary care clinics, a hospital paediatric unit, and private paediatric...

journal_title：Vaccine

authors： Zhong Y,Clapham HE,Aishworiya R,Chua YX,Mathews J,Ong M,Wang J,Murugasu B,Chiang WC,Lee BW,Chin HL

更新日期：2021-01-29 00:00:00

abstract：:The objective of this paper is to review adaptive immunity of young animals using examples from my own experience and from the literature. Trials carried out by us with a modified live and inactivated canine parvovirus vaccine in newborn puppies provide evidence of the immune capacity of these puppies. With regard to ...

journal_title：Vaccine

authors： Chappuis G

更新日期：1998-08-01 00:00:00

abstract：:We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 st...

journal_title：Vaccine

authors： Surendran N,Nicolosi T,Pichichero M

更新日期：2016-11-11 00:00:00

abstract：INTRODUCTION:9-valent human papillomavirus vaccine (9vHPV) was approved by the Food and Drug Administration (FDA) in December 2014. 9vHPV is not recommended during pregnancy, but some women of childbearing age may be inadvertently exposed. This study aims to evaluate reports submitted to the Vaccine Adverse Event Repor...

journal_title：Vaccine

authors： Landazabal CS,Moro PL,Lewis P,Omer SB

更新日期：2019-02-21 00:00:00

abstract：:Respiratory mucosa immunization is capable of eliciting both local and distal mucosal immune responses; it is a potentially powerful yet largely unused modality for vaccination against respiratory diseases. Targeting the lower versus upper airways by aerosol delivery alters the immunogenicity profile of a vaccine, alt...

journal_title：Vaccine

authors： Bolton DL,Song K,Tomaras GD,Rao S,Roederer M

更新日期：2017-01-23 00:00:00

abstract：:Cholera toxin B subunit (CTB) and Escherichia coli heat-labile toxin (LTB) (2 micrograms), each supplemented with a trace amount of cholera toxin (CT) (0.02-20 ng), were examined for the adjuvant effect on antibody (Ab) response against influenza inactivated HA (haemagglutinin) vaccine in Balb/c mice. Each mouse recei...

journal_title：Vaccine

authors： Tamura S,Yamanaka A,Shimohara M,Tomita T,Komase K,Tsuda Y,Suzuki Y,Nagamine T,Kawahara K,Danbara H

更新日期：1994-04-01 00:00:00

abstract：:The trivalent inactivated vaccine (TIV) is used to prevent seasonal influenza virus infection in humans, however, the immunogenicity of this vaccine may be influenced by the priming effect of previous influenza vaccinations or exposure to antigenically related influenza viruses. The current study examines the immunoge...

journal_title：Vaccine

authors： Wang S,Parker C,Taaffe J,Solórzano A,García-Sastre A,Lu S

更新日期：2008-07-04 00:00:00

abstract：:Dengue fever and dengue hemorrhagic fever are endemic throughout tropical and subtropical countries. Four serotypes of dengue viruses (DENV-1 to DENV-4), each with several genotypes including various subclades, are co-distributed in most endemic areas. Infection-neutralizing and -enhancing antibodies are believed to p...

journal_title：Vaccine

authors： Yamanaka A,Suzuki R,Konishi E

更新日期：2014-07-23 00:00:00

abstract：:The correlation between the antigen content of inactivated Newcastle disease (ND) oil emulsion-vaccines and the serological response after immunisation was studied. The haemagglutinin-neuraminidase (HN) and fusion (F) proteins of Newcastle disease virus (NDV) were quantified in 33 inactivated oil-adjuvanted ND vaccine...

journal_title：Vaccine

authors： Maas RA,Komen M,van Diepen M,Oei HL,Claassen IJ

更新日期：2003-07-04 00:00:00

abstract：:Johne's disease in ruminants is caused by the pathogenic bacterium Mycobacterium avium subspecies paratuberculosis (Map). Currently available Map commercial vaccines protect against clinical disease but not infection. In this study, the proprietary Johne's vaccine Neoparasec and an aqueous formulation of Map 316F (Aqu...

journal_title：Vaccine

authors： Begg DJ,Griffin JF

更新日期：2005-10-10 00:00:00

abstract：:The epidemiology of infection due to Haemophilus influenzae type b (Hib) varies in different groups of Australian and New Zealand children. In most populations the annual case attack rate is approximately 40-60 per 100,000 children under 5 years of age and epiglottitis accounts for a relatively high but variable propo...

journal_title：Vaccine

authors： Gilbert GL

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Evidence that respiratory infections trigger stroke suggests that influenza or pneumococcal vaccination might prevent stroke. We aimed to investigate whether influenza or pneumococcal vaccination or both together were associated with reduced risk of stroke or transient ischaemic attack (TIA). METHODS:We use...

journal_title：Vaccine

authors： Siriwardena AN,Asghar Z,Coupland CC

更新日期：2014-03-10 00:00:00

abstract：:Myostatin negatively regulates skeletal muscle growth. It was found that active immunization with myostatin-specific vaccine blocked myostatin function in vivo, which resulted in increase of body weight and muscle composition in mice. However, traditional vaccine and its administration method are expensive and laborio...

journal_title：Vaccine

authors： Zhang T,Yang H,Wang R,Xu K,Xin Y,Ren G,Zhou G,Zhang C,Wang L,Zhang Z

更新日期：2011-10-26 00:00:00

abstract：:A novel recombinant hepatitis B vaccine, trademarked Sci-B-Vac, was evaluated for safety, tolerability and immunogenicity in an open label trial performed in Singapore. The experimental vaccine, derived from Chinese hamster ovary (CHO) cells, consists of hepatitis B surface antigen (HBsAg) particles harbouring all thr...

journal_title：Vaccine

authors： Yap I,Guan R,Chan SH

更新日期：1992-01-01 00:00:00