Abstract:
:The human immune defense system is composed of two distinct elements: innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically, effective vaccines have focused on eliciting pathogen epitope-specific acquired immune responses to protect against infectious diseases; however, such traditional approaches to developing HIV vaccines have been unsuccessful. This review addresses the importance of activating host species-restricted innate immunity to enhance the virus epitope-specific acquired immunity that is needed for HIV vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Takahashi Hdoi
10.1016/j.vaccine.2009.07.086subject
Has Abstractpub_date
2010-05-26 00:00:00pages
B3-7eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)01123-2journal_volume
28 Suppl 2pub_type
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