Species-specific CD1-restricted innate immunity for the development of HIV vaccine.

Abstract:

:The human immune defense system is composed of two distinct elements: innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically, effective vaccines have focused on eliciting pathogen epitope-specific acquired immune responses to protect against infectious diseases; however, such traditional approaches to developing HIV vaccines have been unsuccessful. This review addresses the importance of activating host species-restricted innate immunity to enhance the virus epitope-specific acquired immunity that is needed for HIV vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Takahashi H

doi

10.1016/j.vaccine.2009.07.086

subject

Has Abstract

pub_date

2010-05-26 00:00:00

pages

B3-7

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)01123-2

journal_volume

28 Suppl 2

pub_type

杂志文章,评审

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