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Identification by genomic immunization of a pool of DNA vaccine candidates that confer protective immunity in mice against Neisseria meningitidis serogroup B.

Abstract：

:We have shown previously that expression library immunization is viable alternative approach to induce protective immunity against Neisseria meningitidis serogroup B. In this study we report that few rounds of library screening allow identification of protective pools of defined antigens. A previously reported protective meningococcal library (L8, with 600 clones) was screened and two sub-libraries of 95 clones each were selected based on the induction of bactericidal and protective antibodies in BALB/c mice. After sequence analysis of each clone within these sub-libraries, we identified a pool of 20 individual antigens that induced protective immune responses in mice against N. meningitidis infection, and the observed protection was associated with the induction of bactericidal antibodies. Our studies demonstrate for the first time that ELI combined with sequence analysis is a powerful and efficient tool for identification of candidate antigens for use in a meningococcal vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Yero D,Pajón R,Pérez Y,Fariñas M,Cobas K,Diaz D,Solis RL,Acosta A,Brookes C,Taylor S,Gorringe A

doi

10.1016/j.vaccine.2007.04.084

subject

Has Abstract

pub_date

2007-07-09 00:00:00

pages

5175-88

issue

28

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(07)00536-1

journal_volume

25

pub_type

杂志文章

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