Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex Europaeus-I lectin as M cell target.

abstract：:Travellers often present late for the third dose of hepatitis B vaccination and measuring anti-HBs serology is common practice to ensure that these individuals are protected. We assessed the adequacy of immune response in 86 healthy travellers who had their third dose of hepatitis B (HB) vaccine performed more than 1 ...

journal_title：Vaccine

authors： Jackson Y,Chappuis F,Mezger N,Kanappa K,Loutan L

更新日期：2007-04-30 00:00:00

abstract：AIM:To establish whether universal vaccination of infants with the pneumococcal conjugate vaccine is likely to be cost-effective from the perspective of the health care provider (NHS). METHOD:Two hypothetical cohorts--one vaccinated and one unvaccinated--were followed over their lifetime, and the expected net costs an...

journal_title：Vaccine

authors： Melegaro A,Edmunds WJ

更新日期：2004-10-22 00:00:00

abstract：INTRODUCTION:New vaccine introductions have put strains on vaccine supply chains around the world. While increasing storage and transportation may be the most straightforward options, it is also important to consider what financial and operational benefits can be incurred. In 2012, suboptimal vaccine coverage and impen...

journal_title：Vaccine

authors： Brown ST,Schreiber B,Cakouros BE,Wateska AR,Dicko HM,Connor DL,Jaillard P,Mvundura M,Norman BA,Levin C,Rajgopal J,Avella M,Lebrun C,Claypool E,Paul P,Lee BY

更新日期：2014-07-07 00:00:00

abstract：:Using mass spectrometry and immunological approaches, a heat shock protein 70 associated with lymphatic filariasis (LF) has been identified from a bovine filarial parasite Setaria cervi. A heat shock protein was detected in different life stages of S. cervi when exposed to an elevated temperature of 44 degrees C. A co...

journal_title：Vaccine

authors： Srivastava S,Srikanth E,Liebau E,Rathaur S

更新日期：2010-02-03 00:00:00

abstract：:Viral vectors are promising vaccine candidates for eliciting suitable Ag-specific immune response. Since Mycobacterium tuberculosis (Mtb) normally enters hosts via the mucosal surface of the lung, the best defense against Mtb is mucosal vaccines that are capable of inducing both systemic and mucosal immunity. Although...

journal_title：Vaccine

authors： Watanabe K,Matsubara A,Kawano M,Mizuno S,Okamura T,Tsujimura Y,Inada H,Nosaka T,Matsuo K,Yasutomi Y

更新日期：2014-03-26 00:00:00

abstract：INTRODUCTION:Older adults living in nursing homes (NH) are at high risk of developing influenza and pneumococcal infections. The objectives of this study were to describe vaccination coverage for influenza and pneumococcal among French NH residents and to investigate which NH structure- and organisation-related aspects...

journal_title：Vaccine

authors： de Souto Barreto P,Lapeyre-Mestre M,Vellas B,Rolland Y

更新日期：2014-02-07 00:00:00

abstract：:Since smallpox eradication by the WHO during the 1980s, potency of new vaccines is compared to vaccines that were used during the eradication campaign. In this work we characterize the tail scarification technique in mice as a model for scarification in humans. Similar to humans, mice develop "clinical take" which is ...

journal_title：Vaccine

authors： Melamed S,Paran N,Katz L,Ben-Nathan D,Israely T,Schneider P,Levin R,Lustig S

更新日期：2007-11-07 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common cause of viral bronchiolitis and pneumonia in children. The present study compares the level of attenuation, genetic stability and efficacy of three conditional-lethal temperature-sensitive (ts) mutants of the RSV A2 wild-type virus, designated ts-1, ts-1-NG1, and t...

journal_title：Vaccine

authors： Crowe JE Jr,Collins PL,London WT,Chanock RM,Murphy BR

更新日期：1993-11-01 00:00:00

abstract：:Tuberculosis (TB) is the second leading cause of death by infectious disease worldwide. The only available TB vaccine is the Bacille Calmette-Guerin (BCG). However, parenterally administered Mycobacterium bovis BCG vaccine confers only limited immune protection from pulmonary tuberculosis in humans. There is a need fo...

journal_title：Vaccine

authors： Shen CF,Jacob D,Zhu T,Bernier A,Shao Z,Yu X,Patel M,Lanthier S,Kamen A

更新日期：2016-06-17 00:00:00

abstract：:Leptospirosis is an important zoonotic disease worldwide. Subunit vaccines are an attractive intervention strategy against this disease, but potent, non-toxic adjuvants are necessary components to any effective vaccine. Among various adjuvant candidates, liposomes have garnered recent attention for their capacity as c...

journal_title：Vaccine

authors： Faisal SM,Yan W,McDonough SP,Mohammed HO,Divers TJ,Chang YF

更新日期：2009-10-19 00:00:00

abstract：:Despite a wide array of safe and effective vaccines in use globally, with major impacts on health worldwide, the WHO Strategic Advisory Group of Experts (SAGE) on Immunization has been repeatedly confronted with reports of hesitancy towards accepting specific vaccines or vaccination programmes. This paper summarizes t...

journal_title：Vaccine

authors： Schuster M,Eskola J,Duclos P,SAGE Working Group on Vaccine Hesitancy.

更新日期：2015-08-14 00:00:00

abstract：:Salmonella Enteritidis mutants with deletions in phoP, fliC or phoPfliC were tested for their virulence and their ability to induce parameters of the innate and adaptive immunity in addition to their potential for serological differentiation between vaccinated, non-vaccinated and infected chickens. The double phoPfliC...

journal_title：Vaccine

authors： Methner U,Barrow PA,Berndt A,Rychlik I

更新日期：2011-04-12 00:00:00

abstract：:We tested the hypothesis that removal of viral lipids using diisopropylether can enhance antigenicity of SIVmac251. DIPE delipidation removed cholesterol from SIVmac251 without significant loss of viral protein or RNA. Mice immunized with the same SIV preparation but boosted with delipidated SIVmac251 exhibited signif...

journal_title：Vaccine

authors： Kitabwalla M,Villinger F,Akeefe H,Liao Z,Mayne AE,Gargano L,Conner AP,Maltais JA,Kunas G,Hildreth JE,Ansari AA,Bellotti M

更新日期：2005-09-07 00:00:00

abstract：BACKGROUND:India has faced considerable challenges in eradicating polio. Uttar Pradesh (UP) and Bihar are the two states in India where transmission of polio has never been interrupted. Private pediatricians are important stakeholders for vaccine delivery and maintaining public confidence in vaccines. The purpose of th...

journal_title：Vaccine

authors： Choudhury P,Thacker N,Gargano LM,Weiss PS,Vashishtha VM,Amladi T,Pazol K,Orenstein WA,Omer SB,Hughes JM

更新日期：2011-10-26 00:00:00

abstract：:The ability to readily elicit broadly neutralizing antibodies to HIV-1 remains elusive. We and others have hypothesized that interaction of the viral envelope glycoprotein (Env, gp120-gp41) with its receptor molecules could enhance the exposure of conserved epitopes that may facilitate the elicitation of broadly neutr...

journal_title：Vaccine

authors： Xiao X,Phogat S,Shu Y,Phogat A,Chow YH,Wei OL,Goldstein H,Broder CC,Dimitrov DS

更新日期：2003-10-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) remains a threat to cause epidemics as evidenced by recent sporadic cases in China. In this communication, we evaluated the efficacy and safety of two SARS vaccine candidates based on the recombinant modified vaccinia Ankara (...

journal_title：Vaccine

authors： Czub M,Weingartl H,Czub S,He R,Cao J

更新日期：2005-03-18 00:00:00

abstract：:To study the regulation of the human immune response to hepatitis B surface antigen (HBsAg) we have carefully monitored the in vivo humoral and in vitro cellular immune responses to HBsAg in 50 subjects receiving four doses of hepatitis B vaccine according to a 0, 1, 2, 12 month vaccination scheme. Twenty-three subjec...

journal_title：Vaccine

authors： Leroux-Roels G,Van Hecke E,Michielsen W,Voet P,Hauser P,Pêtre J

更新日期：1994-07-01 00:00:00

abstract：:To study the kinetics of humoral as well as cellular immunity to measles and to test for associated immunosuppression 124 12 month old children were studied twice, before routine MMR and either 14, 22, 30, or 38 days after vaccination. Plaque reduction neutralization (PRN) titres were determined at these time points a...

journal_title：Vaccine

authors： Pabst HF,Spady DW,Carson MM,Stelfox HT,Beeler JA,Krezolek MP

更新日期：1997-01-01 00:00:00

abstract：:Vaccine induced responses are often weaker in those individuals most susceptible to infection, namely the very young and the elderly, highlighting the need for safe and effective vaccine adjuvants. Herein we evaluated different archaeosome formulations as an adjuvant to the H1N1 influenza hemagglutinin protein and com...

journal_title：Vaccine

authors： Stark FC,Akache B,Ponce A,Dudani R,Deschatelets L,Jia Y,Sauvageau J,Williams D,Jamshidi MP,Agbayani G,Wachholz K,Harrison BA,Li X,Krishnan L,Chen W,McCluskie MJ

更新日期：2019-11-08 00:00:00

abstract：:Data from two Swedish pertussis vaccine trials with various combination vaccines were used to compare anti-diphtheria antitoxin concentrations over time between different vaccines, vaccine lots and vaccine schedules. The immune responses were measured with a validated ELISA method.Results are given for 1326 children, ...

journal_title：Vaccine

authors： Tiru M,Hallander HO,Gustafsson L,Storsaeter J,Olin P

更新日期：2000-04-28 00:00:00

abstract：:110 children who were given the complete course of the inactivated hepatitis A vaccine (Havrix) were followed up 10 years later. Age-matched healthy children who were not inoculated served as controls. One month after two primary injections, all children were positive for serum antibody. After 10 years, 99.09% of inoc...

journal_title：Vaccine

authors： Bian GL,Ma R,Dong HJ,Ni HX,Hu FJ,Chen YR,Chen JQ,Zhou SY,Lin YX,Xu GZ

更新日期：2010-07-05 00:00:00

abstract：:CpG-DNA is currently attracting attention as an effective and safe vaccine adjuvant to prevent from microbial infections. In this report, we examined the effects of oligo B, which is a synthetic CpG-DNA, in mucosal administration of Bacillus Calmette-Guérin (BCG) and diphtheria toxoid (DT). Co-administration with olig...

journal_title：Vaccine

authors： Maeyama J,Komiya T,Takahashi M,Isaka M,Goto N,Yamamoto S

更新日期：2009-02-18 00:00:00

abstract：:A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(DL-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine. B...

journal_title：Vaccine

authors： Luo Y,O'Hagan D,Zhou H,Singh M,Ulmer J,Reisfeld RA,James Primus F,Xiang R

更新日期：2003-05-16 00:00:00

abstract：:Iscoms, with rCTB incorporated via the GM1 receptor, enhanced in mice the mucosal immunogenicity of rCTB as antigen after intranasal (i.n.) administration both by inducing IgA response in the remote intestinal tract mucosa and by a 100-fold increase of the specific IgA locally in the lungs. Iscom-matrix as a separate ...

journal_title：Vaccine

authors： Ekström J,Hu KF,Bengtsson KL,Morein B

更新日期：1999-06-04 00:00:00

abstract：:African horse sickness is a lethal viral disease of equids transmitted by biting midges of the Genus Culicoides. The disease is endemic to sub-Saharan Africa but outbreaks of high mortality and economic impact have occurred in the past in non-endemic regions of Africa, Asia and Southern Europe. Vaccination is critical...

journal_title：Vaccine

authors： Manning NM,Bachanek-Bankowska K,Mertens PPC,Castillo-Olivares J

更新日期：2017-10-20 00:00:00

abstract：:Studies have demonstrated that lipid rafts ultimately regulate the endocytosis of anthrax toxin via clathrin dependent pathway. Interestingly, GPI-anchored protein rich rafts have also been shown to be transported down to the endocytic pathway to reducing late endosomes. Taking advantage of this parallelism, we tried ...

journal_title：Vaccine

authors： Midha S,Bhatnagar R

更新日期：2009-03-10 00:00:00

abstract：:There has been controversy about whether cognitive changes occur in early human immunodeficiency virus (HIV) disease. In those studies reporting cognitive changes, these are typically subclinical, and their relationship to daily and/or occupational functioning has not been addressed. The potential effects of changes m...

journal_title：Vaccine

authors： Mapou RL,Rundell JR,Kay GG,Tramont EC

更新日期：1993-01-01 00:00:00

abstract：:Viral hepatitis remains a major contributor to the global disease burden. Mass immunisation strategies against hepatitis B have been adopted by more than 90 developing and industrialised countries. Countries with low hepatitis A endemicity are experiencing cyclical outbreaks and an epidemiological shift, with larger n...

journal_title：Vaccine

authors： Lopalco PL,Salleras L,Barbuti S,Germinario C,Bruguera M,Buti M,Domínguez A

更新日期：2000-10-15 00:00:00

abstract：:HIV-1 Tat protein activates resting cells, rendering them permissive for viral replication. Replication of HIV-1 in vitro is enhanced by intercellular passage of Tat protein and inhibited by anti-Tat antibodies. Tat dependence of HIV-1 replication in vivo during acute, chronic asymptomatic and AIDS stages of infection...

journal_title：Vaccine

authors： Goldstein G,Manson K,Tribbick G,Smith R

更新日期：2000-06-15 00:00:00

abstract：:NetB (necrotic enteritis toxin B) is a recently identified β-pore-forming toxin produced by Clostridium perfringens. This toxin has been shown to play a major role in avian necrotic enteritis. In recent years, a dramatic increase in necrotic enteritis has been observed, especially in countries where the use of antimic...

journal_title：Vaccine

authors： Fernandes da Costa SP,Mot D,Bokori-Brown M,Savva CG,Basak AK,Van Immerseel F,Titball RW

更新日期：2013-08-20 00:00:00