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A randomized controlled trial of low-dose recombinant human interferons alpha-2b nasal spray to prevent acute viral respiratory infections in military recruits.

Abstract：

:The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon alpha-2b (rIFNalpha-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized controlled trial. The results showed that application of the rIFNalpha-2b nasal spray had the benefits in prevention of infections caused by influenza A virus, influenza B virus parainfluenza viruses 1-3 and adenovirus species B. However, no benefit was seen in preventing respiratory syncytial virus. No severe adverse events were reported. Therefore, the rIFNalpha-2b nasal spray was effective and well tolerated for preventing common viral respiratory infections in the military recruits.

journal_name

Vaccine

journal_title

Vaccine

authors

Gao L,Yu S,Chen Q,Duan Z,Zhou J,Mao C,Yu D,Zhu W,Nie J,Hou Y

doi

10.1016/j.vaccine.2010.03.062

subject

Has Abstract

pub_date

2010-06-17 00:00:00

pages

4445-51

issue

28

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)00462-7

journal_volume

28

pub_type

杂志文章,多中心研究,随机对照试验

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