Abstract:
:The persistence of anti-HBs protective levels in groups of children who had been immunized against Hepatitis B 5 and 10 years earlier, in their first year of life, has been studied. The results were analyzed according to the type of vaccine (both plasma-derived and DNA recombinant) and the number of doses administered (three or four doses). In addition, the protective effect of the vaccine in vaccinated subjects was studied in relation to the anti-HBc presence. The serologic results suggest that, in cohorts of children vaccinated 5 years earlier, a higher prevalence of subjects with anti-HBs protective levels was found, when the DNA recombinant vaccines were administered (97.6% for MSD Recombivax and 97.1% for SKF Engerix B); a lower one when the plasma-derived vaccine was used (80.4% Pasteur Merieux, Hevac B). Moreover, in cohorts of children vaccinated with plasma derived vaccine (hevac B) 10 years earlier, a higher prevalence of subjects with anti-HBs protective levels was demonstrated when four doses were administered (76.9%); a lower one when three doses were inoculated (57.5%). The absence of core antibody (anti-HBc) in responders to the vaccination shows the protective efficacy of both the DNA recombinant and plasma derived vaccines. On the other hand the presence of anti-HBc in some anti-HBs negative non-responders subjects shows the susceptibility of these people to infection. In anti-HBs negative vaccinated subjects the appearance of levels of anti-HBs in 95.9% of subjects, 1 week after the administration of a booster dose, demonstrates the presence of a solid immunologic memory.
journal_name
Vaccinejournal_title
Vaccineauthors
Da Villa G,Peluso F,Picciotto L,Bencivenga M,Elia S,Pelliccia MGdoi
10.1016/s0264-410x(96)00140-5subject
Has Abstractpub_date
1996-11-01 00:00:00pages
1503-5issue
16eissn
0264-410Xissn
1873-2518pii
S0264-410X(96)00140-5journal_volume
14pub_type
杂志文章相关文献
VACCINE文献大全abstract:OBJECTIVE:Uptake of meningococcal vaccine (MCV) and tetanus, diphtheria and pertussis (Tdap) vaccine among adolescents has approached Healthy People 2020 goals, but human papillomavirus (HPV) vaccination has not. This study evaluated an intervention using the 4 Pillars™ Practice Transformation Program to increase HPV, ...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2016.11.018
更新日期:2017-01-03 00:00:00
abstract::Neuromuscular diseases (NMDs) encompass a broad spectrum of conditions. Because infections may be relevant to the final prognosis of most NMDs, vaccination appears to be the simplest and most effective solution for protecting NMD patients from vaccine-preventable infections. However, very few studies have evaluated th...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.09.003
更新日期:2014-10-14 00:00:00
abstract:BACKGROUND:Non-specific effects (NSEs) of vaccines have increasingly gained attention in recent years. Recent studies suggest that live vaccines, such as measles vaccine (MV), have beneficial effects on health, while inactivated vaccines, such as the diphtheria-tetanus-pertussis (DTP) vaccine, may have harmful effects....
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.vaccine.2018.02.104
更新日期:2018-04-05 00:00:00
abstract::A human influenza B/Lee/40 virus was cold-adapted by serial passages in embryonated chicken eggs, at progressively lower temperatures, for possible use as a future influenza B vaccine donor strain. Temperature sensitive and cold-adapted phenotypes were achieved as a consequence of the adaptation process. It was determ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2007.12.022
更新日期:2008-02-13 00:00:00
abstract::Defective interfering (DI) virus RNAs result from major deletions in full-length viral RNAs that occur spontaneously during de novo RNA synthesis. These RNAs are packaged into virions that are by definition non-infectious, and are delivered to cells normally targeted by the virion. DI RNAs can only replicate with the ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.03.004
更新日期:2006-05-15 00:00:00
abstract::While heptavalent pneumococcal conjugate vaccine (PCV) has decreased vaccine type invasive pneumococcal disease (IPD) nationwide, rapid serotype replacement and increasing parapneumonic empyema, has been reported in Utah children. The effect of pediatric vaccination on adults in this population is unknown. We identifi...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.10.009
更新日期:2011-11-15 00:00:00
abstract::In Autumn 1990, trivalent split influenza virus vaccine containing A/Taiwan/1/86(H1N1) was used to immunize healthy female employees (n = 104). The 11-12 amino acid differences in the HA1 domain of virus haemagglutinin between A/Taiwan/1/86 and representative epidemic H1N1 strains in Finland in 1991 did not result in ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(93)90126-i
更新日期:1993-01-01 00:00:00
abstract::Globally the most commonly utilised immunisation against influenza is the trivalent inactivated influenza vaccine (TIV) derived from an A/H1N1, an A/H3N2 and aB type influenza virus. Vaccine effectiveness of TIV varies year to year, depending on how well antigenically matched the strains in the vaccine are compared to...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.09.062
更新日期:2017-11-07 00:00:00
abstract::A survey of aged veterans greater than or equal to 85 years old was undertaken to determine their vaccination behaviour prior to mounting a local education campaign on influenza vaccine. A questionnaire inquiring into circumstances which may have influenced their decision to be immunized against influenza was mailed t...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(89)90163-1
更新日期:1989-10-01 00:00:00
abstract::The biological activities of whole-cell pertussis vaccine and a new acellular preparation were compared. It was observed that both preparations were similarly effective in inducing protection in mice against intracerebral challenge with B. pertussis, however, the acellular preparation was approximately 200-fold more p...
journal_title:Vaccine
pub_type: 临床试验,杂志文章
doi:10.1016/0264-410x(85)90005-2
更新日期:1985-03-01 00:00:00
abstract::An N-terminal peptide of the HIV-1 fusion peptide (FP) with eight amino acid residues (FP8) was conjugated to a recombinant Tetanus Toxoid Heavy Chain Fragment C (rTTHc) as a carrier protein to help boosting immunogenicity against HIV-1. In this rapid communication, a unique algorithm to determine FP-rTTHc conjugation...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.04.080
更新日期:2020-06-15 00:00:00
abstract::In 1994, 630 Gambian infants were immunized with three doses of the synthetic polypeptide malaria vaccine SPf66 or with a control vaccine. No significant protection against first or total attacks of malaria was observed among the children who received SPf66. However, the period of follow-up was short. Thus, 532 childr...
journal_title:Vaccine
pub_type: 临床试验,杂志文章
doi:10.1016/s0264-410x(97)00159-x
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Streptococcus pneumoniae is a capsulated bacterium that can cause severe infection in patients with thalassemia major, particularly those who have undergone splenectomy. The absence of the spleen as well as zinc deficiency in splenectomized patients with thalassemia major increases the possibility of devel...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2017.07.011
更新日期:2017-08-16 00:00:00
abstract::During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1...
journal_title:Vaccine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.vaccine.2006.01.067
更新日期:2006-04-24 00:00:00
abstract::Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain facilities. This is advantageous for mass...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.04.055
更新日期:2018-05-31 00:00:00
abstract::Despite of highly active antiretroviral therapy, the response to vaccines in HIV-infected children is poor and short-lived, probably due to a defect in cellular immune responses. We compared the cellular immune response (assessed in terms of IFN-γ production) to tetanus toxoid and to cytomegalovirus in a series of 13 ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.03.035
更新日期:2013-05-07 00:00:00
abstract::The effects of beta-propiolactone (BPL), an alkylating and virus inactivating agent, on the structural and in vitro biological properties of different DNA preparations from BHK-21 cells were investigated. Both uninfected and rabies virus-infected cells were used. Purified cellular DNA (celDNA) was used as the referenc...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(93)90343-v
更新日期:1993-01-01 00:00:00
abstract::This large study investigates the associations between bovine major histocompatibility complex DRB3 alleles and their binding pockets with the immune response to a 40-mer peptide derived from foot-and-mouth disease virus (FMDV) VP1. A crossbred (Charolais and Holstein) cattle population (n=197) was immunised with the ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.09.131
更新日期:2009-12-10 00:00:00
abstract::In many countries, foot and mouth disease (FMD) is controlled by vaccination and surveillance against non-capsid proteins (NCP); therefore vaccines are required not to induce antibodies against NCP. Vaccine purity is evaluated by repeated inoculation of naïve cattle, an expensive and time consuming protocol that raise...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.05.049
更新日期:2010-09-14 00:00:00
abstract::The potency assay currently used to evaluate consistency of manufacture for the anthrax vaccine is contingent upon meeting specified parameters after statistical analysis of the percent survival and time to death of vaccinated guinea pigs after challenge with spores of a virulent strain of Bacillus anthracis. During t...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2003.12.027
更新日期:2004-07-29 00:00:00
abstract::Successful emergency vaccination campaigns rely on effective deployment and vaccination plans. This applies to localised outbreaks as well as for pandemics. In the wake of the 2009 H1N1 influenza pandemic, analysis of the global Vaccine Deployment Initiative, through which the World Health Organization (WHO) donated p...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.11.047
更新日期:2021-01-08 00:00:00
abstract::Effort has been made to identify protective antigens in order to develop a recombinant vaccine against leptospirosis. Several attempts failed to conclusively demonstrate efficacy of vaccine candidates due to the lack of an appropriate model of lethal leptospirosis. The purposes of our study were: (i) to test the virul...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.04.085
更新日期:2008-07-23 00:00:00
abstract::We reported previously on the development of a Bacillus anthracis vaccine strain expressing high levels of recombinant protective antigen (rPA) [Cohen et al., Infec Immun 2000;68(8):4549-58]. To further explore the potential of the B. anthracis platform, we generated several attenuated strains expressing lethal toxin ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2004.11.077
更新日期:2005-12-01 00:00:00
abstract::Concerns about bioterrorism and outbreaks of zoonotic orthopoxvirus require safe and efficacious smallpox vaccines. We previously reported the clinical efficacy and safety profiles of LC16m8, a live, attenuated, cell culture-derived, smallpox vaccine, examined in over 3000 healthy Japanese adults with various vaccinat...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.09.006
更新日期:2019-10-16 00:00:00
abstract::Age-specific force of varicella infection, hospitalisation and death rates in non-immune persons were calculated using an age-based mathematical model and national data for France. A cost-effectiveness model was then applied to hypothetical cohorts of persons aged 15-45 years with a negative or uncertain history of va...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(03)00405-5
更新日期:2003-09-08 00:00:00
abstract::Measles vaccine is widely used, most often in association with mumps and rubella vaccines. We report here the case of a child presenting with fever 8 days after vaccination with a measles-mumps-rubella vaccine. Measles virus was isolated in a throat swab taken 4 days after fever onset. This virus was then further gene...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(01)00495-9
更新日期:2002-02-22 00:00:00
abstract::Enterohemorrhagic Escherichia coli (EHEC) comprise an important group of enteric pathogens causing hemorrhagic colitis and hemolytic uremic syndrome. These bacteria need EspA (E) as a conduct for Tir (T) delivery to the host cell and surface arrayed intimin (I) which docks the bacterium to the translocated Tir. This p...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.07.061
更新日期:2010-10-04 00:00:00
abstract::HIV infection is characterized by chronic immune activation and the establishment of a pool of latently infected cells. Antiretroviral therapy (ART) can suppress viral load to undetectable levels in peripheral blood by standard measure, however immune activation/chronic inflammation and latent infection persist and af...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.04.015
更新日期:2020-06-02 00:00:00
abstract::After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the infant national immunization program (NIP) in the Netherlands in 2006, Streptococcus pneumoniae strains of the non-vaccine serotype 19A emerged and became the dominant serotype in carriage in children and their parents. Similar patterns we...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.11.060
更新日期:2016-01-20 00:00:00
abstract:BACKGROUND:The development of a vaccine against the human gastric pathogen Helicobacter pylori, the main causative agent of gastric adenocarcinoma, has been hampered by a number of issues, including the lack of a mucosal adjuvant for use in humans. Heat shock proteins (Hsp), highly conserved molecules expressed by both...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.02.051
更新日期:2014-04-25 00:00:00