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Characterization of virulence of Leptospira isolates in a hamster model.

Abstract：

:Effort has been made to identify protective antigens in order to develop a recombinant vaccine against leptospirosis. Several attempts failed to conclusively demonstrate efficacy of vaccine candidates due to the lack of an appropriate model of lethal leptospirosis. The purposes of our study were: (i) to test the virulence of leptospiral isolates from Brazil, which are representative of important serogroups that cause disease in humans and animals; and (ii) to standardize the lethal dose 50% (LD(50)) for each of the virulent strains using a hamster (Mesocricetus auratus) model. Five of seven Brazilian isolates induced lethality in a hamster model, with inocula lower than 200 leptospires. Histopathological examination of infected animals showed typical lesions found in both natural and experimental leptospirosis. Results described here demonstrated the potential use of Brazilian isolates as highly virulent strains in challenge experiments using hamster as an appropriate animal model for leptospirosis. Furthermore these strains may be useful in heterologous challenge studies which aim to evaluate cross-protective responses induced by sub-unit vaccine candidates.

journal_name

Vaccine

journal_title

Vaccine

authors

Silva EF,Santos CS,Athanazio DA,Seyffert N,Seixas FK,Cerqueira GM,Fagundes MQ,Brod CS,Reis MG,Dellagostin OA,Ko AI

doi

10.1016/j.vaccine.2008.04.085

subject

Has Abstract

pub_date

2008-07-23 00:00:00

pages

3892-6

issue

31

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)00552-5

journal_volume

26

pub_type

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