Abstract:
:During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1%), culture positive for influenza were enrolled for analysis. The numbers of patients for A/H1N1 and A/H3N2 were insufficient for statistical analysis. For influenza B the odds ratio for vaccinated children to have a maximum fever exceeding 39.5 degrees C was 0.52 (95% CI, 0.30-0.92) Our findings suggest modest impact of influenza vaccination on limiting severity of disease symptoms.
journal_name
Vaccinejournal_title
Vaccineauthors
Kamada M,Nagai T,Kumagai T,Igarashi M,Ihara T,Okafuji T,Ochiai H,Sakiyama H,Shimomura K,Suzuki E,Torigoe S,Miyazaki C,Miyata A,Yuri K,Ito Y,Nakayama T,Kase T,Okuno Ydoi
10.1016/j.vaccine.2006.01.067subject
Has Abstractpub_date
2006-04-24 00:00:00pages
3618-23issue
17eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)00169-1journal_volume
24pub_type
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