Antibodies to measles, mumps and rubella in UK children 4 years after vaccination with different MMR vaccines.


:Persistence of antibodies 4 years after vaccination with measles, mumps and rubella (MMR) vaccine from three different manufacturers was compared in 475 children who received a single injection of vaccine when aged 12-18 months. Antibodies to measles and mumps were measured using a plaque reduction neutralisation assay; rubella antibodies were measured by radial haemolysis and latex agglutination. Children given MMR vaccine containing the Urabe mumps strain were less likely to be antibody negative than those given the Jeryl Lynn mumps strain (39/266, 15% vs 39/204, 19%, p = 0.048). However, the relatively high proportions in both groups without detectable mumps neutralising antibody suggests the probable need for a second dose in order to achieve mumps elimination. No significant differences were found in the proportions with detectable antibody to measles between vaccines containing the Schwarz and the Enders-Edmonston strains. Overall, only 3% of vaccinees were without detectable measles antibody, although a further 28% had a level below 200 mille International Units, the putative protective level for clinical measles. Geometric mean titres (GMTs) to measles were twofold higher in girls vaccinated after than before 14 months of age; GMTs in boys were intermediate and showed no age effect. Over 99% of vaccinees were seropositive to rubella, confirming the excellent immunogenicity of the RA 27/3 rubella strain and the potential for elimination of rubella with a single dose strategy.






Miller E,Hill A,Morgan-Capner P,Forsey T,Rush M




Has Abstract


1995-06-01 00:00:00
















  • Midwives' knowledge, attitudes and confidence in discussing maternal and childhood immunisation with parents: A national study.

    abstract:INTRODUCTION:Despite the enormous benefits of childhood and maternal immunisation to individual and population health, the uptake of maternal vaccines during pregnancy remains suboptimal. Midwives are a trusted information source for parents and play an important role in the provision of immunisation information. Under...


    pub_type: 杂志文章


    authors: Frawley JE,McKenzie K,Sinclair L,Cummins A,Wardle J,Hall H

    更新日期:2020-01-10 00:00:00

  • Has the public lost confidence in vaccines because of a vaccine scandal in China.

    abstract:BACKGROUND:A vaccine manufacturer in China and regulatory authorities have been the focus of widespread outrage due to a vaccine scandal. We conducted a rapid survey during a time of intense mainstream and social media attention to determine whether the public's confidence in vaccines was affected. METHODS:We selected...


    pub_type: 杂志文章


    authors: Han B,Wang S,Wan Y,Liu J,Zhao T,Cui J,Zhuang H,Cui F

    更新日期:2019-08-23 00:00:00

  • An experimental vaccine cocktail for Plasmodium falciparum malaria.

    abstract::Surface proteins from several different life-cycle stages of the malaria parasite Plasmodium falciparum were expressed at high levels in the yeast Saccharomyces cerevisiae. Purified proteins, both individually and in cocktails, were used to immunize mice and goats in conjunction with either Freund's adjuvant or a mura...


    pub_type: 杂志文章


    authors: Bathurst IC,Gibson HL,Kansopon J,Hahm BK,Green KM,Chang SP,Hui GS,Siddiqui WA,Inselburg J,Millet P

    更新日期:1993-01-01 00:00:00

  • Mitigating base-catalysed degradation of periodate-oxidized capsular polysaccharides: Conjugation by reductive amination in acidic media.

    abstract::Reductive amination coupling an aldehyde-containing polysaccharide, generated by periodate oxidation, with the amino groups in protein has been widely used in the synthesis of glycoconjugate vaccines. The conjugation is often achieved under slightly basic conditions via a Schiff's base intermediate followed by its red...


    pub_type: 杂志文章


    authors: Zou W,Williams D,Cox A

    更新日期:2019-02-14 00:00:00

  • Vaccination against hepatitis A during outbreaks starting in schools: what can we learn from experiences in central Italy?

    abstract::Two outbreaks of hepatitis A started almost simultaneously in a maternal school and in a day care centre located at opposite sides of Florence, Italy, at the end of 2002. Both of them originated from immigrant children, and in both cases, hepatitis A was initially not recognised due to aspecific symptoms. While vaccin...


    pub_type: 杂志文章


    authors: Bonanni P,Franzin A,Staderini C,Pitta M,Garofalo G,Cecconi R,Santini MG,Lai P,Innocenti B

    更新日期:2005-03-18 00:00:00

  • Evaluation of immunization injection safety in China, 2010: achievements, future sustainability.

    abstract:OBJECTIVE:The study objectives were to evaluate injection practices in China in the post GAVI project era and provide guidance for policy makers to update national standards for injection practices and further improve vaccination services. METHODS:We conducted a national stratified, cross-sectional survey in October 2...


    pub_type: 杂志文章


    authors: Wu Z,Cui F,Chen Y,Miao N,Gong X,Luo H,Wang F,Zheng H,Kane M,Hadler SC,Hutin YJ,Liang X,Yang W

    更新日期:2013-12-27 00:00:00

  • Serological and epidemiological effects and influence factors of primary immunization with current live attenuated measles vaccine (Hu191) among infants aged 6-15 months.

    abstract::A study of the serological and epidemiological effects of primary immunization with current live attenuated measles vaccine (Hu191) among 503 children aged 6-15 months, was conducted in Jingzhou, Hubei province, China from 1991 to 1998. The results showed that the positive conversion rate of measles IgG was 91.65%, ge...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Youwang Y,Ping W,Feng C

    更新日期:2001-02-28 00:00:00

  • Identification of secreted proteins as novel antigenic vaccine candidates of Haemophilus parasuis serovar 5.

    abstract::Haemophilus parasuis (H. parasuis) is a swine pathogen responsible for the Glässer's disease, which has received more attention in the past decade due to the increasing economic losses in the pig industry worldwide. As traditional inactive vaccine of H. parasuis has obvious disadvantage, to identify efficient immunopr...


    pub_type: 杂志文章


    authors: Li M,Song S,Yang D,Li C,Li G

    更新日期:2015-03-30 00:00:00

  • Predicting the relative impacts of maternal and neonatal respiratory syncytial virus (RSV) vaccine target product profiles: A consensus modelling approach.

    abstract:BACKGROUND:Respiratory syncytial virus (RSV) is the major viral cause of infant and childhood lower respiratory tract disease worldwide. Defining the optimal target product profile (TPP) is complicated due to a wide range of possible vaccine properties, modalities and an incomplete understanding of the mechanism of nat...


    pub_type: 杂志文章


    authors: Pan-Ngum W,Kinyanjui T,Kiti M,Taylor S,Toussaint JF,Saralamba S,Van Effelterre T,Nokes DJ,White LJ

    更新日期:2017-01-05 00:00:00

  • Assessment of epidermal cell viability by near infrared multi-photon microscopy following ballistic delivery of gold micro-particles.

    abstract::The use of gene guns in ballistically delivering DNA vaccine coated gold micro-particles to skin can potentially damage targeted cells, therefore influencing transfection efficiencies. In this paper, we assess cell death in the viable epidermis by non-invasive near infrared two-photon microscopy following micro-partic...


    pub_type: 杂志文章


    authors: Raju PA,McSloy N,Truong NK,Kendall MA

    更新日期:2006-05-22 00:00:00

  • United States of America Department of Health and Human Services support for advancing influenza vaccine manufacturing in the developing world.

    abstract::Since 2005, the Government of the United States of America has provided more than US$ 50 million to advance influenza vaccine development in low-resourced countries. This programme has provided a unique opportunity for the US Government to develop a comprehensive view of, and to understand better the challenges and fu...


    pub_type: 杂志文章,评审


    authors: Perdue ML,Bright RA

    更新日期:2011-07-01 00:00:00

  • DNA versus protein immunisation for production of monoclonal antibodies against Choristoneura fumiferana ecdysone receptor (CfEcR).

    abstract::The full-length ecdysone receptor cDNA of Choristoneura fumiferana (CfEcR-B) was cloned into bacterial expression systems and the recombinant protein was expressed either with a His-tag (His-EcR-B) or glutathione-S-transferase (GST) fusion (GST-EcR-B). The His-EcR-B was expressed mostly as insoluble aggregates, while ...


    pub_type: 杂志文章


    authors: Yang DH,Makhmoudova A,Arif BM,Feng Q,Retnakaran A,Palli SR,Krell PJ

    更新日期:2006-04-12 00:00:00

  • The potential cost-effectiveness of acellular pertussis booster vaccination in England and Wales.

    abstract::A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wa...


    pub_type: 杂志文章


    authors: Edmunds WJ,Brisson M,Melegaro A,Gay NJ

    更新日期:2002-01-31 00:00:00

  • Stability of RNA virus attenuation approaches.

    abstract::The greatest risk from live-attenuated vaccines is reversion to virulence. Particular concerns arise for RNA viruses, which exhibit high mutation frequencies. We examined the stability of 3 attenuation strategies for the alphavirus, Venezuelan equine encephalitis virus (VEEV): a traditional, point mutation-dependent a...


    pub_type: 杂志文章


    authors: Kenney JL,Volk SM,Pandya J,Wang E,Liang X,Weaver SC

    更新日期:2011-03-09 00:00:00

  • Inactivated meningococci and pertussis bacteria are immunogenic and act as mucosal adjuvants for a nasal inactivated influenza virus vaccine.

    abstract::Whole killed meningococci (Nm) and pertussis bacteria (Bp) were tested for mucosal immunogenicity and as mucosal adjuvants for an inactivated influenza virus vaccine given intranasally to unanaesthetized mice. Virus was given alone, or simply mixed with one of the bacterial preparations, in four doses at weekly interv...


    pub_type: 杂志文章


    authors: Berstad AK,Andersen SR,Dalseg R,Dromtorp S,Holst J,Namork E,Wedege E,Haneberg B

    更新日期:2000-03-17 00:00:00

  • Recombinant herpesvirus of turkeys as a vector-based vaccine against highly pathogenic H7N1 avian influenza and Marek's disease.

    abstract::A major challenge for poultry vaccination is the design of vaccines that protect against multiple pathogens via a single protective dose delivered through mass vaccination methods. In this investigation, we examined herpesvirus of turkeys (HVT) as a vaccine vector for delivery of haemagglutinin (HA) antigen of highly ...


    pub_type: 杂志文章


    authors: Li Y,Reddy K,Reid SM,Cox WJ,Brown IH,Britton P,Nair V,Iqbal M

    更新日期:2011-10-26 00:00:00

  • Persistence of protection through 33 months of age provided by immunization in infancy with two three-component acellular pertussis vaccines. Stage II Working Group.

    abstract::A large, randomized, placebo-controlled clinical trial in Italy on two three-component pertussis vaccines, given as DTaP in infancy, one manufactured by SmithKline and Beecham (SB) and one by Chiron Biocine (CB), found each vaccine to be 84% efficacious through the average age of 24 months. The cohort of children enro...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Salmaso S,Mastrantonio P,Wassilak SG,Giuliano M,Anemona A,Giammanco A,Tozzi AE,Ciofi degli Atti ML,Greco D

    更新日期:1998-08-01 00:00:00

  • Inactivated influenza vaccine does not reduce all cause respiratory illness in children with pre-existing medical conditions.

    abstract:BACKGROUND:The effectiveness of inactivated influenza vaccine (IIV) immunization in preventing all cause respiratory illness (RI) in children with pre-existing medical conditions has not been fully established and varies from season to season. This study aims to quantify the overall impact of IIV immunization on primar...


    pub_type: 杂志文章


    authors: de Hoog MLA,Venekamp RP,Meijer A,Sanders EAM,Bruijning-Verhagen PCJL

    更新日期:2020-04-09 00:00:00

  • In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment.

    abstract::Targeting immune checkpoint receptors has emerged as an effective strategy to induce immune-mediated cancer regression in the subset of patients who have significant pre-existing anti-tumor immunity. For the remainder, effective anti tumor responses may require vaccination. Radiotherapy, traditionally used to achieve ...


    pub_type: 杂志文章,评审


    authors: Vanpouille-Box C,Pilones KA,Wennerberg E,Formenti SC,Demaria S

    更新日期:2015-12-16 00:00:00

  • Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction.

    abstract::The seven-valent pneumococcal conjugate vaccine (PCV7) was added to the UK national immunisation programme in September 2006. PCV13 replaced PCV7 in April 2010. As carriage precedes disease cases this study collected carried pneumococci from children each winter from 2006/7 to 2010/11 over PCV introduction. Convention...


    pub_type: 杂志文章


    authors: Gladstone RA,Jefferies JM,Tocheva AS,Beard KR,Garley D,Chong WW,Bentley SD,Faust SN,Clarke SC

    更新日期:2015-04-21 00:00:00

  • Heterologous HA DNA vaccine prime--inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses.

    abstract::The trivalent inactivated vaccine (TIV) is used to prevent seasonal influenza virus infection in humans, however, the immunogenicity of this vaccine may be influenced by the priming effect of previous influenza vaccinations or exposure to antigenically related influenza viruses. The current study examines the immunoge...


    pub_type: 杂志文章


    authors: Wang S,Parker C,Taaffe J,Solórzano A,García-Sastre A,Lu S

    更新日期:2008-07-04 00:00:00

  • Genetic immunization with GPI-anchored anthrax protective antigen raises combined CD1d- and MHC II-restricted antibody responses by natural killer T cell-mediated help.

    abstract::Studies have demonstrated that lipid rafts ultimately regulate the endocytosis of anthrax toxin via clathrin dependent pathway. Interestingly, GPI-anchored protein rich rafts have also been shown to be transported down to the endocytic pathway to reducing late endosomes. Taking advantage of this parallelism, we tried ...


    pub_type: 杂志文章


    authors: Midha S,Bhatnagar R

    更新日期:2009-03-10 00:00:00

  • The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice.

    abstract::Recently the urgency of developing a pandemic influenza vaccine has lead to the re-evaluation of the use of whole virus vaccine. We have compared the humoral immune response and the protective efficacy of whole and split influenza virus vaccines in mice. Whole virus vaccine was more immunogenic particularly after the ...


    pub_type: 杂志文章


    authors: Cox RJ,Hovden AO,Brokstad KA,Szyszko E,Madhun AS,Haaheim LR

    更新日期:2006-11-10 00:00:00

  • Effect of hepatitis A vaccination schedules on immune response.

    abstract::An inactivated hepatitis A vaccine was given to 104 seronegative volunteers aged between 19 and 60 years according to two schedules: 0, 1 and 2 months or 0, 1 and 6 months. The vaccine was well tolerated and 97 and 100% of vaccinees developed a serum antibody response following a single and two doses of vaccine respec...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tilzey AJ,Palmer SJ,Barrow S,Perry KR,Tyrell H,Safary A,Banatvala JE

    更新日期:1992-01-01 00:00:00

  • Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives.

    abstract::Potent liposomal PorA formulations containing various lipopolysaccharide (LPS) derivatives were developed. The following adjuvants were compared: the commonly used aluminum phosphate (AlPO(4)), and three LPS like adjuvants: monophosphoryl lipid A (MPL), lipopolysaccharide (galE LPS) and the less toxic LPS mutant lpxL1...


    pub_type: 杂志文章


    authors: Arigita C,Luijkx T,Jiskoot W,Poelen M,Hennink WE,Crommelin DJ,Ley Pv,Els Cv,Kersten GF

    更新日期:2005-10-17 00:00:00

  • Mucosal immunization with experimental feline immunodeficiency virus (FIV) vaccines induces both antibody and T cell responses but does not protect against rectal FIV challenge.

    abstract::Feline immunodeficiency virus (FIV) is a natural lentiviral pathogen of cats which can be experimentally transmitted via rectal and vaginal routes--the major routes of human immunodeficiency virus type 1 transmission in man. An important objective for lentiviral research is the development of vaccine strategies which ...


    pub_type: 杂志文章


    authors: Finerty S,Stokes CR,Gruffydd-Jones TJ,Hillman TJ,Reeves NA,Whiting CV,Schaaper WM,Dalsgaard K,Harbour DA

    更新日期:2000-08-01 00:00:00

  • Antibody persistence and booster response in adolescents and young adults 4 and 7.5 years after immunization with 4CMenB vaccine.

    abstract:BACKGROUND:Data on duration of protection against invasive meningococcal disease post-vaccination with the recombinant, 4-component, meningococcal serogroup B vaccine (4CMenB) are limited. We evaluated bactericidal activity persistence in adolescents/young adults up to 7.5 years post-primary vaccination with 4CMenB, an...


    pub_type: 杂志文章,多中心研究


    authors: Nolan T,Santolaya ME,de Looze F,Marshall H,Richmond P,Henein S,Rheault P,Heaton K,Perrett KP,Garfield H,Gupta A,Ferguson M,D'Agostino D,Toneatto D,O'Ryan M

    更新日期:2019-02-21 00:00:00

  • The burden of hospitalisations for community-acquired pneumonia (CAP) and pneumococcal pneumonia in adults in Spain (2003-2007).

    abstract::All hospital discharges and deaths related to CAP and pneumococcal-pneumonia from adults over 50 from 2003 to 2007 in Spain were obtained. Among the 447,670 Pneumonia-all causes discharges 17% were pneumococcal pneumonia. The annual hospitalisation rate was 6.27 and 1.09 cases per 1000, respectively. 75,932 deaths for...


    pub_type: 杂志文章


    authors: Gil-Prieto R,García-García L,Alvaro-Meca A,Méndez C,García A,de Miguel AG

    更新日期:2011-01-10 00:00:00

  • How to develop and implement pandemic preparedness plans? The need for a coherent European policy.

    abstract::How should public health authorities confront the threat of pandemic influenza? Is massive stockpiling the answer? If so, the costs could be overwhelming. Or is vaccination of pre-selected segments of the population the best approach? If so, then what about the tough ethical question that must be addressed: for whom--...


    pub_type: 杂志文章



    更新日期:2006-11-10 00:00:00

  • The Health Belief Model in predicting healthcare workers' intention for influenza vaccine uptake in Jordan.

    abstract:BACKGROUND:Theories of health behavior change are being inadequately adopted to understand the reasons behind low influenza vaccination rates among healthcare workers (HCWs). The Theory of Planned Behavior (TPB) is being used to predict intention-behavior relationship while the Health Belief Model (HBM) is being employ...


    pub_type: 杂志文章


    authors: Alhalaseh L,Fayoumi H,Khalil B

    更新日期:2020-10-27 00:00:00