Abstract：
:Despite extensive research, no unifying concept has satisfactorily explained the cause of the sudden infant death syndrome (SIDS). The details are briefly outlined of some of the evidence supporting the hypothesis that common bacterial toxins are important in the aetiology of SIDS. These bacterial toxins act as triggers to initiate a biochemical cascade resulting in death. Data from four research groups, each working independently, indicated that the bacteria Clostridium perfringens, Escherichia coli, Staphylococcus aureus, Streptococcus spp. and Enterococcus spp. were present in higher numbers in infants who had suffered SIDS than in control infants. Certainly more detailed studies need to be performed on the role of bacterial infections in infants. There are many implications arising from this work, particularly the use of vaccination as a means of reducing infections, and consequently the number of SIDS deaths.
journal_name
Vaccinejournal_title
Vaccineauthors
Murrell TG,Murrell WG,Lindsay JAdoi
10.1016/0264-410x(94)90102-3subject
Has Abstractpub_date
1994-03-01 00:00:00pages
365-8issue
4eissn
0264-410Xissn
1873-2518pii
0264-410X(94)90102-3journal_volume
12pub_type
杂志文章,评审相关文献
VACCINE文献大全abstract：:Typhoid vaccination is an important component of typhoid fever prevention and control, and is recommended for public health programmatic use in both endemic and outbreak settings. We reviewed experiences with various vaccination strategies using the currently available typhoid vaccines (injectable Vi polysaccharide va...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2015.04.028
更新日期：2015-06-19 00:00:00
abstract：BACKGROUND:Alternative methods for influenza vaccine production are needed to ensure adequate supplies. METHODS:Healthy adults 50-64 years were assigned randomly to receive one intramuscular injection of trivalent recombinant hemagglutinin (rHA) or U.S. licensed trivalent inactivated vaccine (TIV) containing H1, H3 an...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2011.01.039
更新日期：2011-03-09 00:00:00
abstract：:Natural T (NT) lymphocytes recognize infected cells or microbial compounds without the classical genetic restriction of polymorphic major histocompatibility complex (MHC) molecules. NT cells are mainly composed of alphabeta and gammadelta T lymphocytes that express natural killer (NK) receptors and recognize preferent...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(02)00070-1
更新日期：2002-05-06 00:00:00
abstract：:Aluminum hydroxide is a critical raw material in the production of many vaccines. It is used as an adjuvant in the formulation of the final bulk vaccine, and for this it must meet the specifications of the European Pharmacopeia Monograph. We investigated whether vaccine stability was affected by the presence of trace ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.05.103
更新日期：2015-11-04 00:00:00
abstract：:Amino acid residues 421-436 constitute a comparatively conserved determinant of gp120 that participates in the binding of host cell CD4 receptors by HIV-1. We compared the immunogenicity of synthetic Cys-gp120 (421-436) conjugated to KLH via the N terminal Cys residue (KLH-I) and gp120 (421-436) extended at its N term...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00504-2
更新日期：2003-03-07 00:00:00
abstract：OBJECTIVE:Evaluating HIV-1 specific T-cell response in African populations is sometimes compromised by extensive virus diversity and paucity of non-clade B reagents. We evaluated whether consensus group M (ConM) peptides could serve as comparable substitutes for detecting immune responses in clade A and clade D HIV-1 i...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.05.021
更新日期：2014-06-24 00:00:00
abstract：:Addressing inequities in immunisation must be the main priority for the Decade of Vaccines. Children who remain unreached are those who need vaccination - and other health services - most. Reaching these children and other underserved target groups will require a reorientation of current approaches and resource alloca...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2012.11.088
更新日期：2013-04-18 00:00:00
abstract：:Recombinant hepatitis B surface antigen (HBsAg) particles derived from Chinese hamster ovary (CHO) cells were stored at various conditions for 12-18 months in their naked form or adsorbed to alum (HBV vaccine). The physical, chemical and immunological parameters during storage at -20 degrees C, 4 degrees C, room tempe...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00149-8
更新日期：1999-08-20 00:00:00
abstract：:Preclinical vaccine efficacy studies are generally limited to certain read out parameters such as assessment of virus titers in swabs and organs, clinical signs, serum antibody titers, and pathological changes. These parameters are not always routinely applied and not always scheduled in a logical standardized way. We...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.10.008
更新日期：2012-12-07 00:00:00
abstract：:Porcine epidemic diarrhea (PED) is an important re-emergent infectious disease and inflicts huge economic losses to the swine industry worldwide. To meet the pressing need of developing a safe and cost-efficient PED maternal vaccine, we generated three PED subunit vaccine candidates, using recombined Salmonella flagel...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.01.086
更新日期：2018-03-07 00:00:00
abstract：:Pre-fusion stabilizing mutations (DS-Cav1) in soluble fusion (F) proteins of human respiratory syncytial virus (RSV) were previously reported. Here we investigated the antigenic and immunogenic properties of pre-fusion like RSV F proteins on enveloped virus-like particles (VLP). Additional mutations were introduced to...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.09.041
更新日期：2019-10-16 00:00:00
abstract：:In anticipation of the implementation of new prophylactic HPV vaccines, the WHO is supporting the establishment of a global WHO HPV Laboratory Network whose mission is to "contribute to improving the quality of laboratory services for effective surveillance and monitoring of HPV vaccination impact through enhanced, st...
journal_title：Vaccine
pub_type：
doi：10.1016/j.vaccine.2008.10.062
更新日期：2009-01-14 00:00:00
abstract：:The relevance of CD4+T-cells, viral load and age in the immunological response to influenza infection and vaccination in HIV-1 infected individuals has previously been pointed out. Our study aimed at assessing, in the setting of 2009 A(H1N1)pdm09 influenza vaccination, whether quantification of activation-induced deam...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.03.002
更新日期：2013-04-26 00:00:00
abstract：:The assignment of infectious potency to test articles of adenovirus has been conducted mainly using classical end-point dilution methods, which rely on virus induced cytopathology to reveal the presence of infectious virus. These assays suffer the disadvantages of labor intensity, duration, throughput restriction and ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.04.023
更新日期：2005-08-22 00:00:00
abstract：:As part of a larger study exploring how European citizens' balance issues of public and private interest and the extent to which they are prepared to accept State intervention on a range of public health issues, focus group participants were asked whether childhood immunisation should be a matter of parental choice or...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.11.001
更新日期：2008-01-17 00:00:00
abstract：:Vaccination of poultry against coccidiosis caused by the Eimeria species is almost entirely based upon varied formulations of live parasites. The recent development of a series of protocols that support genetic complementation by transfection in Eimeria now provides an opportunity to utilise live anticoccidial vaccine...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.02.002
更新日期：2012-03-30 00:00:00
abstract：:As sensitivity to erythritol is the main feature of the Brucella abortus B19 vaccine strain, an attempt to define the genetic basis of this phenotypic trait was made in order to explore its usefulness as a means of molecular identification of strain B19. With this purpose, an erythritol-sensitive derivative of B. abor...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)90121-x
更新日期：1994-04-01 00:00:00
abstract：:Improving the ability of DNA-based vaccines to induce potent Type1/Th1 responses against intracellular pathogens in large outbred species is essential. Rhodoccocus equi and equine infectious anemia virus (EIAV) are two naturally occurring equine pathogens that also serve as important large animal models of neonatal im...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.07.055
更新日期：2007-10-23 00:00:00
abstract：:Thirty-two rhesus monkeys were used to evaluate the dose response of a recombinant HEV vaccine, and the efficacy of the vaccine based on the ORF2 protein of the Pakistani strain for pre- and post-exposure vaccination against intravenous challenge with homologous or heterologous virus was examined. Post-exposure vaccin...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(97)00145-x
更新日期：1997-12-01 00:00:00
abstract：:In the last quarter of the year 2000, the meningococcal C conjugated vaccine was incorporated into the routine vaccination schedule in Catalonia (at 2, 4 and 6 months). In addition a vaccination campaign was carried out in children <6 years of age, with a coverage of 96.2%. The effectiveness of the vaccination in this...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00590-x
更新日期：2003-01-30 00:00:00
abstract：:Influenza causes considerable morbidity and mortality and the damage to public health can be considerable. The most effective measures available for the prevention of influenza is vaccination. In most industrialised countries the objective of vaccination is to limit the disease among individuals at risk, especially th...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00507-8
更新日期：2002-12-20 00:00:00
abstract：BACKGROUND:Vaccination uptake at the individual level can be assessed in a variety of ways, including traditional measures of being up-to-date (UTD), measures of UTD that consider dose timing, like age-appropriate vaccination, and risk reduction from individual doses. This analysis compared methods of operationalizing ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.06.033
更新日期：2015-07-31 00:00:00
abstract：:A reverse transcriptase polymerase chain reaction (PCR) was used to amplify a 235 bp hypervariable region of the feline calicivirus (FCV) genome which encodes part of the capsid protein. Sequence from this region was used to compare viruses used in three attenuated vaccines to viruses isolated from vaccinated cats wit...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(97)00059-5
更新日期：1997-08-01 00:00:00
abstract：BACKGROUND:One-dose voluntary varicella vaccination for children was introduced in Beijing since 1998. In Oct 2012, a second dose varicella vaccine (VarV) was recommended to further decrease varicella disease and the outbreaks. We describe the impact of the 2-dose voluntary vaccination strategy on varicella epidemiolog...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.01.087
更新日期：2020-04-29 00:00:00
abstract：BACKGROUND:This study evaluated the immunogenicity and safety of quadrivalent meningococcal conjugate vaccine using tetanus (T) toxoid as carrier protein (MenACWY-TT) co-administered with combined diphtheria-tetanus-acellular pertussis vaccine (Tdap) versus their separate administration in adolescents and young adults....
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2018.04.034
更新日期：2018-07-25 00:00:00
abstract：:The necessity of avoiding the use of animals in vaccine potency testing has been widely recognized. The repeatability and reproducibility of the Expected Percentage of Protection (EPP) as a serological potency surrogate for A24 Cruzeiro foot-and-mouth disease virus (FMDV) strain was assessed, and compared with the res...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.07.012
更新日期：2010-08-31 00:00:00
abstract：:Cytology-based screening has reduced cervical cancer mortality in countries able to implement, sustain and financially support organized programs that achieve broad coverage. These ongoing secondary prevention efforts considerably complicate the question of whether vaccination against human papillomavirus (HPV) types ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2008.06.009
更新日期：2008-08-19 00:00:00
abstract：:The recent resurgence of pertussis in England and Wales has been marked by infant deaths and rising cases in teens and adults. To understand which age cohorts are most responsible for these trends, we employed three separate statistical methods to analyze high-resolution pertussis reports from 1982 to 2012. The fine-g...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.01.046
更新日期：2018-02-21 00:00:00
abstract：:The prospective studies available today confirm the experience gained from several retrospective studies that TBE is a disease with a severe acute clinical course and considerable long-term morbidity. A defined post-encephalitic TBE syndrome exists, causing long-lasting morbidity that often affects the quality of life...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(02)00811-3
更新日期：2003-04-01 00:00:00
abstract：:The potential for smallpox to be disseminated in a bioterror attack has prompted development of new, safer smallpox vaccination strategies. We designed and evaluated immunogenicity and efficacy of a T-cell epitope vaccine based on conserved and antigenic vaccinia/variola sequences, identified using bioinformatics and ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.10.064
更新日期：2011-01-10 00:00:00
