Abstract：
:Preclinical vaccine efficacy studies are generally limited to certain read out parameters such as assessment of virus titers in swabs and organs, clinical signs, serum antibody titers, and pathological changes. These parameters are not always routinely applied and not always scheduled in a logical standardized way. We used computed tomography (CT) imaging as additional and novel read out parameter in a vaccine efficacy study by quantifying alterations in aerated lung volumes in ferrets challenged with the 2009 pandemic A/H1N1 influenza virus. Vaccination protected from marked variations in aerated lung volumes compared to naive controls. The vaccinated group showed a daily gradual mean reduction with a maximum of 7.8%, whereas the controls showed a maximum of 14.3% reduction. The pulmonary opacities evident on CT images were most pronounced in the placebo-treated controls, and corresponded to significantly increased relative lung weights at necropsy. This study shows that consecutive in vivo CT imaging allows for a day to day read out of vaccine efficacy by quantification of altered aerated lung volumes.
journal_name
Vaccinejournal_title
Vaccineauthors
Veldhuis Kroeze EJ,Stittelaar KJ,Teeuwsen VJ,Dijkshoorn ML,van Amerongen G,de Waal L,Kuiken T,Krestin GP,Hinkula J,Osterhaus ADdoi
10.1016/j.vaccine.2012.10.008subject
Has Abstractpub_date
2012-12-07 00:00:00pages
7391-4issue
51eissn
0264-410Xissn
1873-2518pii
S0264-410X(12)01454-5journal_volume
30pub_type
杂志文章相关文献
VACCINE文献大全abstract：:The purpose of this study was to assess clinical protection in pigs vaccinated with a commercially available attenuated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Porcilis) PRRS) and then naturally exposed under field conditions to a heterologous (Italian cluster) strain of virulent PRRSV. A ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.03.028
更新日期：2009-06-08 00:00:00
abstract：:Recent studies have revealed that the interface of gp120 and gp41 and some parts of gp41 are also critical epitopes for elicitation of broadly neutralizing antibodies. Therefore, potential trimeric gp41 or gp140 immunogen candidates are needed. Previously, we developed a trimer motif MTQ and demonstrated that it could...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.09.077
更新日期：2020-11-03 00:00:00
abstract：BACKGROUND:The Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program is the immunization safety monitoring component of FDA's Mini-Sentinel project, a program to actively monitor the safety of medical products using electronic health information. FDA sought to assess the surveillance capabilities of this ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.04.088
更新日期：2013-12-30 00:00:00
abstract：:The phrase "Process is the Product" is often applied to biologics, including multicomponent vaccines composed of complex components that evade complete characterization. Vaccine production processes must be defined and locked early in the development cycle to ensure consistent quality of the vaccine throughout scale-u...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.03.100
更新日期：2018-05-24 00:00:00
abstract：:In the United States, co-administration of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine and tetravalent meningococcal conjugate vaccine (MCV4) is recommended in adolescents. In this clinical study, 1341 adolescents received Tdap (Boostrix® GlaxoSmithKline) and MCV4 (Menactra®, Sanof...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2010.11.057
更新日期：2011-01-29 00:00:00
abstract：:Rhodococcus equi causes severe pneumonia in foals and has recently gained attention as a significant opportunistic pathogen in immunocompromised humans. However, no effective vaccine to prevent rhodococcosis is currently available. In this study, we have engineered the food-grade bacterium Lactococcus lactis to secret...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.10.026
更新日期：2011-12-09 00:00:00
abstract：:To study the regulation of the human immune response to hepatitis B surface antigen (HBsAg) we have carefully monitored the in vivo humoral and in vitro cellular immune responses to HBsAg in 50 subjects receiving four doses of hepatitis B vaccine according to a 0, 1, 2, 12 month vaccination scheme. Twenty-three subjec...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(94)90290-9
更新日期：1994-07-01 00:00:00
abstract：:The development of single-dose vaccines, mainly those administered during childhood, which would effectively protect against certain diseases, would be a very important advance towards better immunization coverage and protection against the respective pathogens. Biodegradable polymeric microspheres which are 'programm...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(93)90241-o
更新日期：1993-01-01 00:00:00
abstract：:The objective of this paper is to review adaptive immunity of young animals using examples from my own experience and from the literature. Trials carried out by us with a modified live and inactivated canine parvovirus vaccine in newborn puppies provide evidence of the immune capacity of these puppies. With regard to ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(98)00110-8
更新日期：1998-08-01 00:00:00
abstract：:Formalin-killed Streptococcus difficile strains used as vaccines delivered intraperitoneally were able to protect tilapia against a challenge of 100 LD50. The protection obtained was not strain specific. A vaccine based on an S. difficile extract containing 50% protein conjugated to alum also protected tilapia challen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)00067-w
更新日期：1995-06-01 00:00:00
abstract：:Since its registration in 2002, Gudair® vaccine has become the key tool for managing paratuberculosis in sheep in Australia. This study was conducted to evaluate its effectiveness in reducing paratuberculosis prevalence in 12 flocks over more than one decade. Flocks with variable initial prevalence (5, 4 and 3 with lo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.08.064
更新日期：2016-09-30 00:00:00
abstract：:Feline immunodeficiency virus (FIV) is a natural lentiviral pathogen of cats which can be experimentally transmitted via rectal and vaginal routes--the major routes of human immunodeficiency virus type 1 transmission in man. An important objective for lentiviral research is the development of vaccine strategies which ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00131-6
更新日期：2000-08-01 00:00:00
abstract：:Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of Salmonella Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a b...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.04.035
更新日期：2018-05-17 00:00:00
abstract：:In this study, we tested the hypothesis that adoptive transfer of dendritic cells (DCs) transfected ex vivo with mRNA encoding hepatitis C virus (HCV) NS3/4A would initiate potent HCV-specific protective immune responses in vivo. Murine DCs were transfected with NS3/4A mRNA or eGFP mRNA using either electroporation or...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.11.046
更新日期：2007-02-26 00:00:00
abstract：:In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV). This T-cell epitope is capable of inducing a robust T-cell proliferative response in vaccinated goats with different genetic backgrounds and to provid...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.08.043
更新日期：2006-01-30 00:00:00
abstract：BACKGROUND:Adolescent HPV vaccination in minority and low income populations with high cervical cancer incidence and mortality could reduce disparities. Safety-net primary care clinics are a key delivery site for improving vaccination rates in these populations. PURPOSE:To examine prevalence of HPV initiation (≥ 1 dos...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.11.031
更新日期：2012-03-16 00:00:00
abstract：:In this work, we explored the potential of cationic solid lipid nanoparticles (cSLN) as efficient adjuvants for inactivated foot and mouth disease virus (iFMDV) vaccine. The cSLN were prepared by O/W emulsion method with Compritol 888 ATO as lipid matrix, and were modified by cationic lipid Didodecyldimethylammonium b...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.02.004
更新日期：2020-03-04 00:00:00
abstract：:This article presents the World Health Organization's (WHO) recommendations on the use of polio vaccine excerpted from the WHO position paper on polio vaccines - March 2016, published in the Weekly Epidemiological Record [1]. This position paper on polio vaccines replaces the 2014 WHO position paper [2]. The position ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.11.017
更新日期：2017-03-01 00:00:00
abstract：:Generating broadly neutralizing antibodies with candidate vaccines has remained an elusive goal. Consequently, vaccine candidates developed have aimed at eliciting cell-mediated immune effector activities (CMI) that could delay disease progression, and maybe also limit secondary transmission, by controlling virus repl...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2009.01.039
更新日期：2009-03-23 00:00:00
abstract：:The HA1 domain of influenza A viruses is critical for immune escape and host receptor recognition. However, the association between HA1 evolution and host species-specific adaptations remains unclear. We have identified the amino acid sites that are related to the host species-specific adaptations by systematically co...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.09.071
更新日期：2010-11-23 00:00:00
abstract：PURPOSE:In April 2007, Panama introduced Hepatitis A universal vaccination using a two-dose schedule (Havrix(®)junior; GSK Vaccines, Belgium). We assessed the impact of this hepatitis A vaccine three years after it was recommended for universal mass vaccination in Panama. MATERIALS AND METHODS:Hepatitis A vaccination ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.04.100
更新日期：2015-06-22 00:00:00
abstract：OBJECTIVE:To compare the economic impact of high-dose trivalent (HD) versus standard-dose trivalent (SD) influenza vaccination on direct medical costs for cardio-respiratory hospitalizations in adults aged 65 years or older enrolled in the United States (US) Veteran's Health Administration (VHA). METHODS:Leveraging a ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.06.066
更新日期：2019-07-26 00:00:00
abstract：:The O specific polysaccharide (OSP) of the lipopolysaccharide (LPS) of Salmonella enterica serovar Paratyphi A is a protective antigen and the target for vaccine development. LPS is the major constituent of the outer membrane of S. Paratyphi A with the OSP exposed on the surface, in addition to the cell associated LPS...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.02.090
更新日期：2014-05-01 00:00:00
abstract：:In March 2010, Brazil introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in the routine infant immunization program using a 4-dose schedule and catch-up for children <23months. We investigated PCV10 effect on nasopharyngeal carriage with vaccine-type Streptococcus pneumoniae (Spn) and non-typeable Haemoph...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.09.027
更新日期：2016-11-04 00:00:00
abstract：:In response to the resurgence of mumps, the Korean Armed Forces started the measles-mumps-rubella (MMR) vaccination to all new recruits regardless of prior vaccination history. We evaluated the effectiveness of the vaccination by comparing the incidence between the military and civilian populations before and after im...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.06.025
更新日期：2017-07-13 00:00:00
abstract：BACKGROUND:Streptococcus pyogenes (group A Streptococcus, Strep A) is a widespread pathogen that continues to pose a significant threat to human health. The development of a Strep A vaccine remains an unmet global health need. One of the major vaccine strategies is the use of M protein, which is a primary virulence det...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.12.005
更新日期：2020-02-05 00:00:00
abstract：:Assuming that the level of Bacille Calmette Guerin (BCG) coverage gives a measure of access to immunisation services, it is possible to derive what fraction of infants are not immunised against measles due to under-utilisation of existing services (rather than unavailability of services). According to the most recent ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00264-x
更新日期：2001-10-12 00:00:00
abstract：:In a previous study, children 18 to 36 months of age and seropositive for respiratory syncytial virus (RSV) were vaccinated with an RSV subunit vaccine (PFP-1) consisting of the viral fusion protein. Vaccines developed substantial increases in anti-fusion and neutralizing antibody and exhibited protection against RSV ...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/0264-410x(94)90316-6
更新日期：1994-05-01 00:00:00
abstract：:At the Netherlands Vaccine Institute (NVI) a vaccine against Neisseria meningitidis serogroup B organisms based on different porA subtypes contained in outer membrane vesicles (OMVs) is in advanced stage of development and will be evaluated in clinical trial studies in the near future. In order to meet the expected de...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.06.008
更新日期：2007-08-21 00:00:00
abstract：:The aim of this study was to determine the rubella seroprevalence in women of reproductive age. This cross-sectional study was conducted on women aged 15-49 years. Serologic studies were performed by using the ELISA method. The number of women enrolled in the study was 607, the mean age was 30.7+/-9.3 years and 13.2% ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.09.033
更新日期：2007-01-15 00:00:00
