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PED subunit vaccine based on COE domain replacement of flagellin domain D3 improved specific humoral and mucosal immunity in mice.

Abstract：

:Porcine epidemic diarrhea (PED) is an important re-emergent infectious disease and inflicts huge economic losses to the swine industry worldwide. To meet the pressing need of developing a safe and cost-efficient PED maternal vaccine, we generated three PED subunit vaccine candidates, using recombined Salmonella flagellin (rSF) as a mucosal molecular adjuvant. Domain D3 in rSF was replaced with COE domain of PEDV to generate rSF-COE-3D. COE fused to the flanking C'/N' terminal of rSF yielded rSF-COE-C and rSF-COE-N. As a result, rSF-COE-3D could significantly improve COE specific antibody production including serum IgG, serum IgA, mucosal IgA and PEDV neutralizing antibody. Furthermore, rSF-COE-3D elicited more CD3+CD8+ T cell and cytokine production of IFN-γ and IL-4 in mouse splenocytes. In summary, our data showed that rSF-COE-3D could improve specific humoral and mucosal immunity in mice, thus suggesting that rSF-COE-3D could be applied as a novel efficient maternal PED vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Li Q,Peng O,Wu T,Xu Z,Huang L,Zhang Y,Xue C,Wen Z,Zhou Q,Cao Y

doi

10.1016/j.vaccine.2018.01.086

subject

Has Abstract

pub_date

2018-03-07 00:00:00

pages

1381-1388

issue

11

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(18)30159-2

journal_volume

36

pub_type

杂志文章

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