Abstract：
:Three vaccines, BCG alone, BCG + 10(7) killed Mycobacterium vaccae and 10(8) killed M. vaccae alone, were studied in children living in close contact with leprosy. In the year before vaccination, 14/446 (3.1%) children had developed leprosy. Among those who were not vaccinated, 9/74 (12.2%) developed the disease in the first 4 years of the study and 5/65 (7.7%) developed the disease in the second 4 years. In comparison with this, among those vaccinated, 20/343 (5.8%) developed leprosy in the first 4 years and 5/323 (1.5%) developed leprosy in the second 4 years. This represents 52.5% protection in the first 4 years and 80.5% in the second 4 years. There were no significant differences in protection afforded by each of the three vaccines but the success of the killed preparation of M. vaccae is an important finding.
journal_name
Vaccinejournal_title
Vaccineauthors
Truoc LV,Ly HM,Thuy NK,Trach DD,Stanford CA,Stanford JLdoi
10.1016/s0264-410x(01)00052-4subject
Has Abstractpub_date
2001-05-14 00:00:00pages
3451-8issue
25-26eissn
0264-410Xissn
1873-2518pii
S0264410X01000524journal_volume
19pub_type
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