Abstract：
:Universal infant vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) has nearly eliminated PCV7-serotype invasive pneumococcal disease (IPD) in young U.S. children, but has been accompanied by increases in the incidence of serotype 19A IPD. Because antibiotic-non-susceptible 19A has increased more than antibiotic-susceptible 19A, antibiotic selection pressure could be contributing to this trend. We developed a dynamic compartmental transmission model of pneumococcus to better understand the causes of this rise and to estimate the impact of vaccines or changes in antibiotic use on future IPD incidence in the U.S. in <2 year-olds. The model predicted that with current practices, serotype 19A IPD incidence will plateau at about the 2007 level over the next few years. The model suggests that antibiotic usage played a major role in the rise in antibiotic-non-susceptible 19A IPD, with a lesser contribution from PCV7 vaccination. However, hypothetical large decreases in antibiotic use starting in 2008 are predicted to yield only gradual decreases in antibiotic-non-susceptible 19A IPD. On the other hand, vaccines with modest (20%) effectiveness against 19A (or 6A or PCV7-serotypes) carriage are predicted to substantially (by 80%) decrease the incidence of IPD caused by those serotypes within 10 years of implementation. Our findings highlight that vaccine effects on colonization are key to their overall benefits. In addition, serotype changes following vaccine introduction may have multifactorial origins, with antibiotic use an important factor for resistant strains such as 19A.
journal_name
Vaccinejournal_title
Vaccineauthors
Van Effelterre T,Moore MR,Fierens F,Whitney CG,White L,Pelton SI,Hausdorff WPdoi
10.1016/j.vaccine.2010.03.030subject
Has Abstractpub_date
2010-05-07 00:00:00pages
3650-60issue
21eissn
0264-410Xissn
1873-2518pii
S0264-410X(10)00377-4journal_volume
28pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immuniza...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2013.05.016
更新日期：2013-07-11 00:00:00
abstract：:Hepatitis B infections are responsible for more than 300 thousand deaths per year in the Western Pacific Region. Because of this high burden, the countries and areas of the Region established a goal of reducing hepatitis B chronic infection prevalence among children to less than 1% by 2017. This study was conducted to...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2016.03.060
更新日期：2016-05-27 00:00:00
abstract：:This paper briefly reviews work on vaccine development since the early 1950s with special emphasis on identification of immunogens and their presentation to the host so as to elicit an immune response. This is illustrated primarily by a discussion of the development of a candidate meningococcal B vaccine based on a ca...
journal_title：Vaccine
pub_type： 历史文章,杂志文章,评审
doi：10.1016/s0264-410x(88)80016-1
更新日期：1988-04-01 00:00:00
abstract：:To assess human papillomavirus (HPV) prevalence and genotype distribution by age and cervical cytology/histology status among women undergoing routine gynecological examinations, and to discuss the possible impact on preventive strategies. Liquid-based cytology (LBC) samples were tested for HPV DNA, mRNA, and HPV geno...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.06.013
更新日期：2012-07-27 00:00:00
abstract：:Adjuvants help antigen to elicit an early, high and long-lasting immune response with less antigen, thus saving on vaccine production costs. In recent years, adjuvants received much attention because of the development of purified, subunit and synthetic vaccines which are poor immunogens and require adjuvants to evoke...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/0264-410x(95)00011-o
更新日期：1995-10-01 00:00:00
abstract：:We employed DNA shuffling and screening technologies to develop a single recombinant dengue envelope (E) antigen capable of inducing neutralizing antibodies against all four antigenically distinct dengue serotypes. By DNA shuffling of codon-optimized dengue 1-4 E genes, we created a panel of novel chimeric clones expr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.07.100
更新日期：2006-01-16 00:00:00
abstract：:The calculation of p(epitope) values, a sequence-based measure of antigenic distance between strains, was developed for human influenza. The potential to apply the p(epitope) value to equine influenza vaccine strain selection was assessed. There was a negative correlation between p(epitope) value and vaccine efficacy ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.06.070
更新日期：2013-12-09 00:00:00
abstract：:A gene associated with lipopolysaccharide (LPS) transport was cloned from a local clinical Vibrio cholerae O1 strain of the Ogawa serotype by using the Lactococcus lactis nisin-controlled expression (NICE) system. The V. cholerae wzm gene, which codes for an integral membrane transporter protein, was expressed and tar...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.02.012
更新日期：2012-05-02 00:00:00
abstract：:The smallpox vaccine Vaccinia was successfully used to eradicate smallpox, but although very effective, it was a very reactogenic vaccine and responsible for the deaths of one or two people per million vaccinated. Modified Vaccinia virus Ankara (MVA) is a replication-deficient and attenuated derivative, also used in t...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2013.03.020
更新日期：2013-09-06 00:00:00
abstract：:Promotional campaigns recommend immunisation against influenza in healthcare workers (HCWs) but the uptake in this group remains low. We conducted a survey study during the 2008-2009 influenza vaccination period amongst future HCWs to quantify uptake and identify barriers to immunisation. Overall uptake was 8.0% (95% ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.04.066
更新日期：2010-06-23 00:00:00
abstract：OBJECTIVE:We investigated whether and to what extent the uptake of the Human Papillomavirus (HPV) vaccine by girls aged 12-18 was related to the cervical cancer screening history of age-appropriate older female household members (assumed to be their mothers) in Flanders (Belgium). METHODS:We studied administrative rec...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.08.039
更新日期：2011-10-26 00:00:00
abstract：:Over a period of 1 year a seroepidemiological study was conducted at the outpatient clinic of a trauma department. Immunity to diphtheria was determined in serum samples from 558 injured patients (205 women and 353 men, age from 18 to 70). Diphtheria-antitoxin concentrations were measured with an enzyme immunoassay an...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00341-8
更新日期：2000-12-08 00:00:00
abstract：INTRODUCTION:Determining vaccine responsiveness is challenging in immune compromised individuals. The microbead array (MBA) assay is a rapid, inexpensive test for evaluating influenza vaccine immunogenicity. MBA performance was compared to hemagglutination inhibition assay (HAI) utilizing HIV seropositive vaccine recip...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2016.05.020
更新日期：2016-06-30 00:00:00
abstract：:Salmonella Enteritidis mutants with deletions in phoP, fliC or phoPfliC were tested for their virulence and their ability to induce parameters of the innate and adaptive immunity in addition to their potential for serological differentiation between vaccinated, non-vaccinated and infected chickens. The double phoPfliC...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.02.030
更新日期：2011-04-12 00:00:00
abstract：BACKGROUND:Concern arose in 2010 that reactogenicity, particularly febrile seizures, to influenza A/H1N1-containing 2010-2011 trivalent seasonal inactivated influenza vaccine (TIV) could occur in young children who had been previously immunized and/or infected with the pandemic strain. We conducted a pre-season study o...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.vaccine.2012.03.046
更新日期：2012-05-14 00:00:00
abstract：OBJECTIVE:To compare timely birth dose (TBD) coverage of hepatitis B vaccine and socio-economic inequality distribution of TBD coverage between 2011 and 2016 in rural areas of western China. METHODS:In western China, using multi-stage probability proportion to size sampling, 2633 and 1929 children aged 0-35 months wit...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.05.085
更新日期：2018-06-22 00:00:00
abstract：:The outer capsid protein VP4 is an important target for the development of a recombinant rotavirus vaccine because it mediates the attachment and penetration of rotavirus. Due to the poor solubility of full-length VP4, VP8 was explored as candidate rotavirus vaccines in the past years. In previous studies, it has been...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.03.011
更新日期：2018-04-12 00:00:00
abstract：:110 children who were given the complete course of the inactivated hepatitis A vaccine (Havrix) were followed up 10 years later. Age-matched healthy children who were not inoculated served as controls. One month after two primary injections, all children were positive for serum antibody. After 10 years, 99.09% of inoc...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.04.096
更新日期：2010-07-05 00:00:00
abstract：:Myostatin negatively regulates skeletal muscle growth. It was found that active immunization with myostatin-specific vaccine blocked myostatin function in vivo, which resulted in increase of body weight and muscle composition in mice. However, traditional vaccine and its administration method are expensive and laborio...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.08.007
更新日期：2011-10-26 00:00:00
abstract：INTRODUCTION:Observational studies of influenza vaccine effectiveness often study persons seeking medical care for acute respiratory infection (ARI). We conducted a pilot study to determine if vaccine effectiveness could be estimated in the general population with a novel rolling cross-sectional survey sampling design ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.09.051
更新日期：2014-11-12 00:00:00
abstract：:A choice-format, conjoint-analysis survey was developed and fielded to estimate how features of human papillomavirus (HPV) vaccines affect mothers' perceived benefit and stated vaccine uptake for daughters. Data were collected from a national sample of 307 U.S. mothers of girls aged 13-17 years who had not yet receive...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.12.024
更新日期：2010-02-17 00:00:00
abstract：:Dengue virus (DENV) is the causal agent of severe disease and, in some cases, mortality in humans, but no licensed vaccines against dengue are available. An effective vaccine against dengue requires long-term humoral and cellular immune responses. Several viral proteins have been the subjects of intense research, espe...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.03.009
更新日期：2013-05-01 00:00:00
abstract：:Infectious bronchitis virus (IBV) is an endemic disease of chickens and a major contributor to economic losses for the poultry industry despite vaccination. Recent observations indicated that chicks may have an immature immune system immediately after hatching when vaccinated for IBV. Therefore we hypothesized that ea...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.04.026
更新日期：2015-05-28 00:00:00
abstract：:Viral hepatitis remains a major contributor to the global disease burden. Mass immunisation strategies against hepatitis B have been adopted by more than 90 developing and industrialised countries. Countries with low hepatitis A endemicity are experiencing cyclical outbreaks and an epidemiological shift, with larger n...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00193-6
更新日期：2000-10-15 00:00:00
abstract：:In the present study the homologous and heterologous type and subtype specific cellular immune response induced by a wild type inactivated whole virus H5N1 Influenza (A/Vietnam/1203/2004) vaccine was evaluated. Two immunizations with the Vero cell derived H5N1 influenza vaccine on Day 0 and Day 21 induced significant ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.10.065
更新日期：2010-12-16 00:00:00
abstract：:Despite a wide array of safe and effective vaccines in use globally, with major impacts on health worldwide, the WHO Strategic Advisory Group of Experts (SAGE) on Immunization has been repeatedly confronted with reports of hesitancy towards accepting specific vaccines or vaccination programmes. This paper summarizes t...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2015.04.035
更新日期：2015-08-14 00:00:00
abstract：:The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vacci...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.04.082
更新日期：2018-06-07 00:00:00
abstract：:To evaluate primary care physicians' attitude towards implementation of rotavirus (RV) immunisation into the Swiss immunisation schedule, an eight-question internet-based questionnaire was sent to the 3799 subscribers of InfoVac, a nationwide web-based expert network on immunisation issues, which reaches >95% of paedi...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.05.097
更新日期：2009-07-30 00:00:00
abstract：:Patients with malignancies are considered to be at increased risk of acquiring influenza. Because of higher complication and case fatality rates, preventive measures such as vaccination are of great interest. The objective of this study was to assess the acceptability, tolerability and immunogenicity of an adjuvant-fr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.09.005
更新日期：2012-11-06 00:00:00
abstract：:WHO is now celebrating more than 30 years of freedom from smallpox. What was originally seen as a victory over an ancient scourge can now be viewed as an epidemiologically driven programme to overcome governmental inertia and under-achievement in delivering an off-patent vaccine. Though efforts are accelerating global...
journal_title：Vaccine
pub_type： 社论
doi：10.1016/j.vaccine.2009.08.006
更新日期：2010-01-22 00:00:00
