Abstract：
:Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immunization against other infectious diseases, including those that have been refractory to traditional vaccination methods. Live rAds can express intact antigens from free-standing transgenes during replication in infected cells. Alternatively, antigenic epitopes can be displayed on the rAd capsid itself, allowing presentation of the epitope to the immune system both prior to and during replication of the virus. Such capsid-display rAds offer a novel vaccine approach that could be used either independently of or in combination with transgene expression strategies to provide a new tool in the search for protection from infectious disease.
journal_name
Vaccinejournal_title
Vaccineauthors
Deal C,Pekosz A,Ketner Gdoi
10.1016/j.vaccine.2013.05.016subject
Has Abstractpub_date
2013-07-11 00:00:00pages
3236-43issue
32eissn
0264-410Xissn
1873-2518pii
S0264-410X(13)00594-Xjournal_volume
31pub_type
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