Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica.

Abstract:

:Cattle produce specific serum antibody mainly of the IgG1 isotype in response to infection with the liver fluke, Fasciola hepatica. In these animals a positive correlation between fluke-specific serum IgG1 levels and fluke-burden in non-immunized infected animals was observed. In contrast, immunization of cattle with a combination of the fluke-derived antigens cathepsin L2 (CL2) and fluke haemoglobin (FHb) in Freund's complete/incomplete adjuvant (FCA/FLA) induced a specific antibody response involving IgG2, as well as IgG1. These immunized animals also exhibited very high (72%) levels of protection against a subsequent challenge infection. When the vaccine was administered in FIA alone the specific antibody response, while still involving IgG1 and IgG2, was of lower magnitude (10-fold and 100-fold, respectively) and no significant reduction in fluke burden was observed following challenge. Nevertheless, in these animals, a strong IgG2 response was associated with low fluke burdens. These results provide further evidence of the non-protective nature of specific immune responses in cattle following F. hepatica infection, and demonstrate that vaccination can induce a qualitatively different, and protective, response.

journal_name

Vaccine

journal_title

Vaccine

authors

Mulcahy G,O'Connor F,McGonigle S,Dowd A,Clery DG,Andrews SJ,Dalton JP

doi

10.1016/s0264-410x(97)00289-2

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

932-9

issue

9-10

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(97)00289-2

journal_volume

16

pub_type

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